The crucial role of nociceptin opioid peptide (NOP) receptor in attenuating relapse to morphine/methamphetamine (poly-drug) addiction in mice

The crucial role of nociceptin opioid peptide (NOP) receptor in attenuating relapse to morphine/methamphetamine (poly-drug) addiction in mice

A combination of buprenorphine/naltrexone treatment had been proven to successfully attenuate relapse (reinstatement) to morphine/methamphetamine (poly-drug) addiction in mice using a conditioned place preference (CPP) model. This treatment combination exhibits a mixed opioid receptor pharmacologica...

Full description

Bibliographic Details
Main Authors: Ridzwan, Irna Elina, Abdul Rahman, Nor Akhi Hijriyati, Wasli, Nur Syafinaz
Format: Article
Language:English
Published: A and V Publication 2017
Subjects:
RS Pharmacy and materia medica
Online Access:http://irep.iium.edu.my/63442/
http://irep.iium.edu.my/63442/
http://irep.iium.edu.my/63442/1/63442_The%20crucial%20role%20of%20nociceptin%20opioid%20peptide%20%28NOP%29.pdf
id iium-63442
recordtype eprints
spelling iium-634422018-04-26T08:59:20Z http://irep.iium.edu.my/63442/ The crucial role of nociceptin opioid peptide (NOP) receptor in attenuating relapse to morphine/methamphetamine (poly-drug) addiction in mice Ridzwan, Irna Elina Abdul Rahman, Nor Akhi Hijriyati Wasli, Nur Syafinaz RS Pharmacy and materia medica A combination of buprenorphine/naltrexone treatment had been proven to successfully attenuate relapse (reinstatement) to morphine/methamphetamine (poly-drug) addiction in mice using a conditioned place preference (CPP) model. This treatment combination exhibits a mixed opioid receptor pharmacological activities (mu/kappa antagonist and partial NOP agonist). Thus, this recent study aimed to investigate the independent role of the NOP receptor in attenuating relapse to this poly-drug addiction. The male Swiss albino mice were made dependent on 7.5 mg/kg morphine/1.0 mg/kg methamphetamine (poly-drug). The mice were injected with SB 612111 (a selective NOP antagonist) during reinstatement phase, 30 minutes before the administration of0.3 mg/kg buprenorphine/1.0 mg/kg naltrexone combination. The priming dose of poly-drug (2.5 mg/kg morphine/1.0 mg/kg methamphetamine) were given 10 minutes later. The percentage of time spent at the drug-paired compartment was compared with the control group (did not receive SB 612111 treatment). The results revealed that the relapse to poly-drug addiction happened in the group of mice that received SB 612111 prior to buprenorphine/naltrexone (53.81 ± 11.23 %, n = 6). This result was significantly different compared to its own baseline (before the mice were made dependent on poly-drug [-5.37 ± 6.42 %, n = 9, p < 0.05]). In contrast, relapse was significantly attenuated (reduced) in the group of mice that did not receive SB 612111 prior to buprenorphine/naltrexone (19.14 ± 16.89 %, n = 5). The percentage of time spent at the drug-paired compartment was found to be not significantly different compared to its own baseline (-16.14 ± 4.81 %, n = 13). The result suggests that an agonist activity at the NOP receptor is crucial in attenuating relapse to morphine/methamphetamine (poly-drug) addiction. Hence, further investigation needs to be done to evaluate the involvement of this receptor at the brain level. A and V Publication 2017-12-30 Article PeerReviewed application/pdf en http://irep.iium.edu.my/63442/1/63442_The%20crucial%20role%20of%20nociceptin%20opioid%20peptide%20%28NOP%29.pdf Ridzwan, Irna Elina and Abdul Rahman, Nor Akhi Hijriyati and Wasli, Nur Syafinaz (2017) The crucial role of nociceptin opioid peptide (NOP) receptor in attenuating relapse to morphine/methamphetamine (poly-drug) addiction in mice. Research Journal of Pharmacy and Technology, 10 (12). pp. 4488-4550. ISSN 0974-3618 E-ISSN 0974-360X http://rjptonline.org/AbstractView.aspx?PID=2017-10-12-79
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic RS Pharmacy and materia medica
spellingShingle RS Pharmacy and materia medica
Ridzwan, Irna Elina
Abdul Rahman, Nor Akhi Hijriyati
Wasli, Nur Syafinaz
The crucial role of nociceptin opioid peptide (NOP) receptor in attenuating relapse to morphine/methamphetamine (poly-drug) addiction in mice
description A combination of buprenorphine/naltrexone treatment had been proven to successfully attenuate relapse (reinstatement) to morphine/methamphetamine (poly-drug) addiction in mice using a conditioned place preference (CPP) model. This treatment combination exhibits a mixed opioid receptor pharmacological activities (mu/kappa antagonist and partial NOP agonist). Thus, this recent study aimed to investigate the independent role of the NOP receptor in attenuating relapse to this poly-drug addiction. The male Swiss albino mice were made dependent on 7.5 mg/kg morphine/1.0 mg/kg methamphetamine (poly-drug). The mice were injected with SB 612111 (a selective NOP antagonist) during reinstatement phase, 30 minutes before the administration of0.3 mg/kg buprenorphine/1.0 mg/kg naltrexone combination. The priming dose of poly-drug (2.5 mg/kg morphine/1.0 mg/kg methamphetamine) were given 10 minutes later. The percentage of time spent at the drug-paired compartment was compared with the control group (did not receive SB 612111 treatment). The results revealed that the relapse to poly-drug addiction happened in the group of mice that received SB 612111 prior to buprenorphine/naltrexone (53.81 ± 11.23 %, n = 6). This result was significantly different compared to its own baseline (before the mice were made dependent on poly-drug [-5.37 ± 6.42 %, n = 9, p < 0.05]). In contrast, relapse was significantly attenuated (reduced) in the group of mice that did not receive SB 612111 prior to buprenorphine/naltrexone (19.14 ± 16.89 %, n = 5). The percentage of time spent at the drug-paired compartment was found to be not significantly different compared to its own baseline (-16.14 ± 4.81 %, n = 13). The result suggests that an agonist activity at the NOP receptor is crucial in attenuating relapse to morphine/methamphetamine (poly-drug) addiction. Hence, further investigation needs to be done to evaluate the involvement of this receptor at the brain level.
format Article
author Ridzwan, Irna Elina
Abdul Rahman, Nor Akhi Hijriyati
Wasli, Nur Syafinaz
author_facet Ridzwan, Irna Elina
Abdul Rahman, Nor Akhi Hijriyati
Wasli, Nur Syafinaz
author_sort Ridzwan, Irna Elina
title The crucial role of nociceptin opioid peptide (NOP) receptor in attenuating relapse to morphine/methamphetamine (poly-drug) addiction in mice
title_short The crucial role of nociceptin opioid peptide (NOP) receptor in attenuating relapse to morphine/methamphetamine (poly-drug) addiction in mice
title_full The crucial role of nociceptin opioid peptide (NOP) receptor in attenuating relapse to morphine/methamphetamine (poly-drug) addiction in mice
title_fullStr The crucial role of nociceptin opioid peptide (NOP) receptor in attenuating relapse to morphine/methamphetamine (poly-drug) addiction in mice
title_full_unstemmed The crucial role of nociceptin opioid peptide (NOP) receptor in attenuating relapse to morphine/methamphetamine (poly-drug) addiction in mice
title_sort crucial role of nociceptin opioid peptide (nop) receptor in attenuating relapse to morphine/methamphetamine (poly-drug) addiction in mice
publisher A and V Publication
publishDate 2017
url http://irep.iium.edu.my/63442/
http://irep.iium.edu.my/63442/
http://irep.iium.edu.my/63442/1/63442_The%20crucial%20role%20of%20nociceptin%20opioid%20peptide%20%28NOP%29.pdf
first_indexed 2023-09-18T21:29:59Z
last_indexed 2023-09-18T21:29:59Z
_version_ 1777412445768253440

Similar Items