Immunohistochemical expression of estrogen receptor alpha in benign prostatic hyperplasia and prostatic carcinoma in Iraqi patients

The human prostate has a remarkably high incidence of hyperplastic and neoplastic diseases. Benign prostatic hyperplasia( BPH) occur in about 70% of men over 70 years old, and prostatic carcinoma is the second leading cause of cancer related death in men. Prostate cancer is one of the predominant ca...

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Main Authors:	Mohammed, Wafaa R., Al-obaidie, Salim R., Al-Ani, Imad M., Matloup, Enas I., Al-obaidie, Ahmed S.
Format:	Article
Language:	English
Published:	Microscopy Society of Singapore 2018
Subjects:	QM Human anatomy QP Physiology RB Pathology RC Internal medicine
Online Access:	http://irep.iium.edu.my/63800/ http://irep.iium.edu.my/63800/ http://irep.iium.edu.my/63800/1/Immunohis%20Expression%20of%20Estrogen%20Receptor.pdf

id	iium-63800
recordtype	eprints
spelling	iium-638002018-05-22T07:13:35Z http://irep.iium.edu.my/63800/ Immunohistochemical expression of estrogen receptor alpha in benign prostatic hyperplasia and prostatic carcinoma in Iraqi patients Mohammed, Wafaa R. Al-obaidie, Salim R. Al-Ani, Imad M. Matloup, Enas I. Al-obaidie, Ahmed S. QM Human anatomy QP Physiology RB Pathology RC Internal medicine The human prostate has a remarkably high incidence of hyperplastic and neoplastic diseases. Benign prostatic hyperplasia( BPH) occur in about 70% of men over 70 years old, and prostatic carcinoma is the second leading cause of cancer related death in men. Prostate cancer is one of the predominant cancers in Iraq. The aim of the study is to evaluate the expression of estrogen receptor alpha in BPH and prostatic carcinoma immunohistochemically and to correlate ER-α expression in prostatic carcinoma (PCa) with Gleason grading system in tissue samples from BPH and PCa patients of Iraqi population. We investigated the localization of ER-α in twenty case of BPH and twenty case of PCa in a retrospective study. Epithelial immunostaining was present in (70%) of PCa and (25%) of BPH while stromal localization was observed in (25%) and (5%) respectively. Among the positive cases of PCa, the highest percentage (35.72%) were Gleason score 8. The increased epithelial immunostaining for ER-α in PCa than in BPH suggest that ER-α may has a role in carcinogenesis of prostate. Microscopy Society of Singapore 2018-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/63800/1/Immunohis%20Expression%20of%20Estrogen%20Receptor.pdf Mohammed, Wafaa R. and Al-obaidie, Salim R. and Al-Ani, Imad M. and Matloup, Enas I. and Al-obaidie, Ahmed S. (2018) Immunohistochemical expression of estrogen receptor alpha in benign prostatic hyperplasia and prostatic carcinoma in Iraqi patients. Annals of Microscopy, 17. pp. 21-27. ISSN 0219-2209 http://www.microscopy.org.sg/journal/Annals_of_Microscopy_Vol_17%20(2018).pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QM Human anatomy QP Physiology RB Pathology RC Internal medicine
spellingShingle	QM Human anatomy QP Physiology RB Pathology RC Internal medicine Mohammed, Wafaa R. Al-obaidie, Salim R. Al-Ani, Imad M. Matloup, Enas I. Al-obaidie, Ahmed S. Immunohistochemical expression of estrogen receptor alpha in benign prostatic hyperplasia and prostatic carcinoma in Iraqi patients
description	The human prostate has a remarkably high incidence of hyperplastic and neoplastic diseases. Benign prostatic hyperplasia( BPH) occur in about 70% of men over 70 years old, and prostatic carcinoma is the second leading cause of cancer related death in men. Prostate cancer is one of the predominant cancers in Iraq. The aim of the study is to evaluate the expression of estrogen receptor alpha in BPH and prostatic carcinoma immunohistochemically and to correlate ER-α expression in prostatic carcinoma (PCa) with Gleason grading system in tissue samples from BPH and PCa patients of Iraqi population. We investigated the localization of ER-α in twenty case of BPH and twenty case of PCa in a retrospective study. Epithelial immunostaining was present in (70%) of PCa and (25%) of BPH while stromal localization was observed in (25%) and (5%) respectively. Among the positive cases of PCa, the highest percentage (35.72%) were Gleason score 8. The increased epithelial immunostaining for ER-α in PCa than in BPH suggest that ER-α may has a role in carcinogenesis of prostate.
format	Article
author	Mohammed, Wafaa R. Al-obaidie, Salim R. Al-Ani, Imad M. Matloup, Enas I. Al-obaidie, Ahmed S.
author_facet	Mohammed, Wafaa R. Al-obaidie, Salim R. Al-Ani, Imad M. Matloup, Enas I. Al-obaidie, Ahmed S.
author_sort	Mohammed, Wafaa R.
title	Immunohistochemical expression of estrogen receptor alpha in benign prostatic hyperplasia and prostatic carcinoma in Iraqi patients
title_short	Immunohistochemical expression of estrogen receptor alpha in benign prostatic hyperplasia and prostatic carcinoma in Iraqi patients
title_full	Immunohistochemical expression of estrogen receptor alpha in benign prostatic hyperplasia and prostatic carcinoma in Iraqi patients
title_fullStr	Immunohistochemical expression of estrogen receptor alpha in benign prostatic hyperplasia and prostatic carcinoma in Iraqi patients
title_full_unstemmed	Immunohistochemical expression of estrogen receptor alpha in benign prostatic hyperplasia and prostatic carcinoma in Iraqi patients
title_sort	immunohistochemical expression of estrogen receptor alpha in benign prostatic hyperplasia and prostatic carcinoma in iraqi patients
publisher	Microscopy Society of Singapore
publishDate	2018
url	http://irep.iium.edu.my/63800/ http://irep.iium.edu.my/63800/ http://irep.iium.edu.my/63800/1/Immunohis%20Expression%20of%20Estrogen%20Receptor.pdf
first_indexed	2023-09-18T21:30:29Z
last_indexed	2023-09-18T21:30:29Z
_version_	1777412477843144704

Immunohistochemical expression of estrogen receptor alpha in benign prostatic hyperplasia and prostatic carcinoma in Iraqi patients

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