Scanning electron microscopic studies on the effects of Xiang Sha Yang Wei Wan on ethanol-induced gastric ulcer in the rats

Objective: The purpose of the present study was to investigate the gastro-protective potential of Xiang Sha Yang Wei Wan (XSYWW) against lesions in gastric mucosa layers induced by ethanol in experimental rats using scanning electron microscopy (SEM). Methods: Thirty healthy male Sprague-Dawley rats...

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Main Authors:	Al-Ani, Imad Matloub Dally, Saliem, Ahmed Muhammed, Abdel Wahab, Emad Mohamad Nafie, Faisal, Ghasak Ghazi
Format:	Article
Language:	English
Published:	Microscopy Society (Singapore) 2018
Subjects:	RB Pathology RM Therapeutics. Pharmacology RM214 Diet therapy. Diet and dietectics in disease
Online Access:	http://irep.iium.edu.my/63802/ http://irep.iium.edu.my/63802/ http://irep.iium.edu.my/63802/1/63802_Scanning%20Electron%20Microscopic.pdf

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spelling	iium-638022019-01-23T02:07:05Z http://irep.iium.edu.my/63802/ Scanning electron microscopic studies on the effects of Xiang Sha Yang Wei Wan on ethanol-induced gastric ulcer in the rats Al-Ani, Imad Matloub Dally Saliem, Ahmed Muhammed Abdel Wahab, Emad Mohamad Nafie Faisal, Ghasak Ghazi RB Pathology RM Therapeutics. Pharmacology RM214 Diet therapy. Diet and dietectics in disease Objective: The purpose of the present study was to investigate the gastro-protective potential of Xiang Sha Yang Wei Wan (XSYWW) against lesions in gastric mucosa layers induced by ethanol in experimental rats using scanning electron microscopy (SEM). Methods: Thirty healthy male Sprague-Dawley rats (250-300 gm) were divided into three groups. Group I (control group); gastric ulcers were induced by administering 100% ethanol (1 ml/200 g). Group II (Pre-treatment group) was divided into two subgroups; they were orally fed with 1.0 gm/kg and 2.0 gm/kg respectively of XSYWW solution. Thirty minutes later they were administered with absolute ethanol as in group I. Group III, (post-treatment group) was given an oral dose of 2gm/kg of XSYWW solution after one hour of ethanol administration. Five rats from groups I, and III were sacrificed on day 1, 2 and 3 while the animals of group II were sacrificed one hour after ethanol administration. Results: SEM study of the surface of the gastric mucosa from group I showed multiple ulcers of packed swollen cells and appearance of underlying connective tissue. The gastric mucosa of group II rats showed less severity ulcers with the formation of flattened, mesh like structures in the mucosal epithelium; while those of group III showed signs of improvement and regeneration of the mucosal surface. Conclusion: Pre- or post-treated rats with XSYWW revealed a protective effect against ethanol-induced gastric mucosal lesion. Microscopy Society (Singapore) 2018-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/63802/1/63802_Scanning%20Electron%20Microscopic.pdf Al-Ani, Imad Matloub Dally and Saliem, Ahmed Muhammed and Abdel Wahab, Emad Mohamad Nafie and Faisal, Ghasak Ghazi (2018) Scanning electron microscopic studies on the effects of Xiang Sha Yang Wei Wan on ethanol-induced gastric ulcer in the rats. Annals of Microscopy, 17. pp. 28-35. ISSN 0219-2209 http://www.microscopy.org.sg/journal/Annals_of_Microscopy_Vol_17%20(2018).pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RB Pathology RM Therapeutics. Pharmacology RM214 Diet therapy. Diet and dietectics in disease
spellingShingle	RB Pathology RM Therapeutics. Pharmacology RM214 Diet therapy. Diet and dietectics in disease Al-Ani, Imad Matloub Dally Saliem, Ahmed Muhammed Abdel Wahab, Emad Mohamad Nafie Faisal, Ghasak Ghazi Scanning electron microscopic studies on the effects of Xiang Sha Yang Wei Wan on ethanol-induced gastric ulcer in the rats
description	Objective: The purpose of the present study was to investigate the gastro-protective potential of Xiang Sha Yang Wei Wan (XSYWW) against lesions in gastric mucosa layers induced by ethanol in experimental rats using scanning electron microscopy (SEM). Methods: Thirty healthy male Sprague-Dawley rats (250-300 gm) were divided into three groups. Group I (control group); gastric ulcers were induced by administering 100% ethanol (1 ml/200 g). Group II (Pre-treatment group) was divided into two subgroups; they were orally fed with 1.0 gm/kg and 2.0 gm/kg respectively of XSYWW solution. Thirty minutes later they were administered with absolute ethanol as in group I. Group III, (post-treatment group) was given an oral dose of 2gm/kg of XSYWW solution after one hour of ethanol administration. Five rats from groups I, and III were sacrificed on day 1, 2 and 3 while the animals of group II were sacrificed one hour after ethanol administration. Results: SEM study of the surface of the gastric mucosa from group I showed multiple ulcers of packed swollen cells and appearance of underlying connective tissue. The gastric mucosa of group II rats showed less severity ulcers with the formation of flattened, mesh like structures in the mucosal epithelium; while those of group III showed signs of improvement and regeneration of the mucosal surface. Conclusion: Pre- or post-treated rats with XSYWW revealed a protective effect against ethanol-induced gastric mucosal lesion.
format	Article
author	Al-Ani, Imad Matloub Dally Saliem, Ahmed Muhammed Abdel Wahab, Emad Mohamad Nafie Faisal, Ghasak Ghazi
author_facet	Al-Ani, Imad Matloub Dally Saliem, Ahmed Muhammed Abdel Wahab, Emad Mohamad Nafie Faisal, Ghasak Ghazi
author_sort	Al-Ani, Imad Matloub Dally
title	Scanning electron microscopic studies on the effects of Xiang Sha Yang Wei Wan on ethanol-induced gastric ulcer in the rats
title_short	Scanning electron microscopic studies on the effects of Xiang Sha Yang Wei Wan on ethanol-induced gastric ulcer in the rats
title_full	Scanning electron microscopic studies on the effects of Xiang Sha Yang Wei Wan on ethanol-induced gastric ulcer in the rats
title_fullStr	Scanning electron microscopic studies on the effects of Xiang Sha Yang Wei Wan on ethanol-induced gastric ulcer in the rats
title_full_unstemmed	Scanning electron microscopic studies on the effects of Xiang Sha Yang Wei Wan on ethanol-induced gastric ulcer in the rats
title_sort	scanning electron microscopic studies on the effects of xiang sha yang wei wan on ethanol-induced gastric ulcer in the rats
publisher	Microscopy Society (Singapore)
publishDate	2018
url	http://irep.iium.edu.my/63802/ http://irep.iium.edu.my/63802/ http://irep.iium.edu.my/63802/1/63802_Scanning%20Electron%20Microscopic.pdf
first_indexed	2023-09-18T21:30:29Z
last_indexed	2023-09-18T21:30:29Z
_version_	1777412477990993920

Scanning electron microscopic studies on the effects of Xiang Sha Yang Wei Wan on ethanol-induced gastric ulcer in the rats

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