In vivo evaluation of orthopaedic metal implant coated with silver composite: potential treatment modality for implant related infection

The aimed of this study is to evaluate the potential effect of orthopaedic metal implant (plate) coated with silver composite in in vivo experiment setting using rabbit as animal model. Our hypothesis was that orthopaedics implant coated with silver would exert both bacteriostatic and bactericidal...

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Main Authors:	Mohd Jan, Nurul Hafiza, Zulkifly, Ahmad Hafiz, Ibrahim, Mohd Zulfadzli, Sha'ban, Munirah
Format:	Article
Language:	English
Published:	Tissue Engineering and Regenerative Medicine Society of Malaysia 2017
Subjects:	RD701 Orthopedics RD92 Wounds and injuries
Online Access:	http://irep.iium.edu.my/63977/ http://irep.iium.edu.my/63977/ http://irep.iium.edu.my/63977/1/In%20Vivo%20Evaluation%20of%20Orthopaedic%20Metal%20Implant%20Coated%20with%20Silver%20Composite%20-%20Potential%20Treatment%20Modality%20for%20Implant%20Related%20Infection.pdf

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recordtype	eprints
spelling	iium-639772018-07-10T18:37:23Z http://irep.iium.edu.my/63977/ In vivo evaluation of orthopaedic metal implant coated with silver composite: potential treatment modality for implant related infection Mohd Jan, Nurul Hafiza Zulkifly, Ahmad Hafiz Ibrahim, Mohd Zulfadzli Sha'ban, Munirah RD701 Orthopedics RD92 Wounds and injuries The aimed of this study is to evaluate the potential effect of orthopaedic metal implant (plate) coated with silver composite in in vivo experiment setting using rabbit as animal model. Our hypothesis was that orthopaedics implant coated with silver would exert both bacteriostatic and bactericidal effects against certain microorganisms. With the approval from the Institutional Animal Care and Use Committee, all rabbits were randomly divided into two groups and underwent surgical procedure. In Group 1(n=6), the right tibia was implanted with a silver-coated metal plate. While in Group 2 (n=6), the left tibia was implanted with a non-coated metal plate. The plates were implanted after six hours of tibial bone exposure. No antibiotics were administered. Animal were sacrificed at three weeks. The implanted tibia was excised en bloc and evaluated by means of microbial assessments, radiograph evaluation, gross inspection and histological analysis for any infection effects. After 3 weeks of implantation, microbial analysis revealed fewer colonies were noted at study group compared to control. By combining the radiograph, gross and histological data collected during the experimental follow up, there is no periosteal reaction noted at the surrounding on implanted area. The outcome of this study revealed positive response of the silver as antibacterial agent. This study indicated that silver has antibacterial properties. This result suggested that orthopaedic metal implant coated with silver composite may have the potential to prevent implant related infections. Tissue Engineering and Regenerative Medicine Society of Malaysia 2017-12-31 Article PeerReviewed application/pdf en http://irep.iium.edu.my/63977/1/In%20Vivo%20Evaluation%20of%20Orthopaedic%20Metal%20Implant%20Coated%20with%20Silver%20Composite%20-%20Potential%20Treatment%20Modality%20for%20Implant%20Related%20Infection.pdf Mohd Jan, Nurul Hafiza and Zulkifly, Ahmad Hafiz and Ibrahim, Mohd Zulfadzli and Sha'ban, Munirah (2017) In vivo evaluation of orthopaedic metal implant coated with silver composite: potential treatment modality for implant related infection. Regenerative Research, 6 (1). p. 14. E-ISSN 2232-0822 http://regres.tesma.org.my/index.html
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RD701 Orthopedics RD92 Wounds and injuries
spellingShingle	RD701 Orthopedics RD92 Wounds and injuries Mohd Jan, Nurul Hafiza Zulkifly, Ahmad Hafiz Ibrahim, Mohd Zulfadzli Sha'ban, Munirah In vivo evaluation of orthopaedic metal implant coated with silver composite: potential treatment modality for implant related infection
description	The aimed of this study is to evaluate the potential effect of orthopaedic metal implant (plate) coated with silver composite in in vivo experiment setting using rabbit as animal model. Our hypothesis was that orthopaedics implant coated with silver would exert both bacteriostatic and bactericidal effects against certain microorganisms. With the approval from the Institutional Animal Care and Use Committee, all rabbits were randomly divided into two groups and underwent surgical procedure. In Group 1(n=6), the right tibia was implanted with a silver-coated metal plate. While in Group 2 (n=6), the left tibia was implanted with a non-coated metal plate. The plates were implanted after six hours of tibial bone exposure. No antibiotics were administered. Animal were sacrificed at three weeks. The implanted tibia was excised en bloc and evaluated by means of microbial assessments, radiograph evaluation, gross inspection and histological analysis for any infection effects. After 3 weeks of implantation, microbial analysis revealed fewer colonies were noted at study group compared to control. By combining the radiograph, gross and histological data collected during the experimental follow up, there is no periosteal reaction noted at the surrounding on implanted area. The outcome of this study revealed positive response of the silver as antibacterial agent. This study indicated that silver has antibacterial properties. This result suggested that orthopaedic metal implant coated with silver composite may have the potential to prevent implant related infections.
format	Article
author	Mohd Jan, Nurul Hafiza Zulkifly, Ahmad Hafiz Ibrahim, Mohd Zulfadzli Sha'ban, Munirah
author_facet	Mohd Jan, Nurul Hafiza Zulkifly, Ahmad Hafiz Ibrahim, Mohd Zulfadzli Sha'ban, Munirah
author_sort	Mohd Jan, Nurul Hafiza
title	In vivo evaluation of orthopaedic metal implant coated with silver composite: potential treatment modality for implant related infection
title_short	In vivo evaluation of orthopaedic metal implant coated with silver composite: potential treatment modality for implant related infection
title_full	In vivo evaluation of orthopaedic metal implant coated with silver composite: potential treatment modality for implant related infection
title_fullStr	In vivo evaluation of orthopaedic metal implant coated with silver composite: potential treatment modality for implant related infection
title_full_unstemmed	In vivo evaluation of orthopaedic metal implant coated with silver composite: potential treatment modality for implant related infection
title_sort	in vivo evaluation of orthopaedic metal implant coated with silver composite: potential treatment modality for implant related infection
publisher	Tissue Engineering and Regenerative Medicine Society of Malaysia
publishDate	2017
url	http://irep.iium.edu.my/63977/ http://irep.iium.edu.my/63977/ http://irep.iium.edu.my/63977/1/In%20Vivo%20Evaluation%20of%20Orthopaedic%20Metal%20Implant%20Coated%20with%20Silver%20Composite%20-%20Potential%20Treatment%20Modality%20for%20Implant%20Related%20Infection.pdf
first_indexed	2023-09-18T21:30:44Z
last_indexed	2023-09-18T21:30:44Z
_version_	1777412493157597184

In vivo evaluation of orthopaedic metal implant coated with silver composite: potential treatment modality for implant related infection

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