Calcium phosphate based Synthetic Bone Construct (SBC) as a temporary spacer for bone defect before bone transport
INTRODUCTION: Bone defect following resection of unhealthy bone often become contracted and fill with fibrous tissue. This will lead to resistance during bone transport, fibrous tissue interposition and skin invagination at the docking site. We report a case where synthetic bone constructs (SB...
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Malaysian Orthopaedic Association (MOA)
2018
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| Online Access: | http://irep.iium.edu.my/63989/ http://irep.iium.edu.my/63989/ http://irep.iium.edu.my/63989/1/Calcium%20Phosphate%20Based%20Synthetic%20Bone%20Construct%20%28SBC%29%20As%20A%20Temporary%20Spacer%20For%20Bone%20Defect%20Before%20Bone%20Transport.pdf |
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iium-639892018-06-01T07:47:44Z http://irep.iium.edu.my/63989/ Calcium phosphate based Synthetic Bone Construct (SBC) as a temporary spacer for bone defect before bone transport AI, Muhamad Syafiz Mohd Yusof, Nazri Sulong, Ahmad Fadzli S, Mohd Aizat Azfar A, Nur Lidawati RD701 Orthopedics INTRODUCTION: Bone defect following resection of unhealthy bone often become contracted and fill with fibrous tissue. This will lead to resistance during bone transport, fibrous tissue interposition and skin invagination at the docking site. We report a case where synthetic bone constructs (SBC) was used as a temporary spacer to prevent valley formation and soft tissue interposition during bone transport. The SBC dissolved slowly and thus allowing the bone to be transported with minimal resistance and preventing fibrous tissue formation in the bone gap. METHODS: A 30 year-old lady had a 4 cm bone gap following resection of unhealthy bone for nonunion following open grade IIIB distal tibia fracture. The gap was filled with SBC and ilizarov circular frame was assembled for bone transport. SBC is a biodegradable osteoconductive material made from calcium phosphate based materials. It is manufactured by Granulab (M) Sdn Bhd in a GMP accredited factory and certified by British Standard Institute (BSI). 5 cc of SBC was mix with 4 mls of bone marrow aspirate in a cup. It is mix in a sterile OT environment and put in a mold to make it into small pellet. The mixture was allowed to be hardened for 20 minutes before inserted into the bone defect. RESULTS: The transported segment docks after 2 month. There was no skin invagination and valley formation. When the docking site was opened, the gap was filled with partially dissolved calcium phosphate. There was minimal soft tissue interposition. Figure 1: Plain radiograph post op, 1 month and during docking Figure 2: Clinical picture during mixing of SBC with marrow aspirate, making pellet using mold and opening of docking site showing calcium phosphate material with minimal fibrous tissue interposition. DISCUSSIONS: Although calcium phosphate has osteoconductive property, we did not observe any any bone formation at the gap although we mix it with bone marrow aspirate. Calcium Phosphate can also be used as an antibiotic carrier for local slow release delivery following resection of infected bone. CONCLUSION: Calcium phosphate is effective as a temporary spacer to fill the gap during bone transport. REFERENCES: 1. Thirumal M. Med J Malaysia.2001; 56:44-52 2. McKee M et al. J Orthop Trauma 201;.24: 483-490 Malaysian Orthopaedic Association (MOA) 2018 Article PeerReviewed application/pdf en http://irep.iium.edu.my/63989/1/Calcium%20Phosphate%20Based%20Synthetic%20Bone%20Construct%20%28SBC%29%20As%20A%20Temporary%20Spacer%20For%20Bone%20Defect%20Before%20Bone%20Transport.pdf AI, Muhamad Syafiz and Mohd Yusof, Nazri and Sulong, Ahmad Fadzli and S, Mohd Aizat Azfar and A, Nur Lidawati (2018) Calcium phosphate based Synthetic Bone Construct (SBC) as a temporary spacer for bone defect before bone transport. Malaysian Orthopaedic Journal, 12 (Supplement A). p. 1. ISSN 1985-2533 E-ISSN 2232-111X http://www.morthoj.org/supplements/2018/EL02-Synthetic-Bone-Construct.pdf |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English |
| topic |
RD701 Orthopedics |
| spellingShingle |
RD701 Orthopedics AI, Muhamad Syafiz Mohd Yusof, Nazri Sulong, Ahmad Fadzli S, Mohd Aizat Azfar A, Nur Lidawati Calcium phosphate based Synthetic Bone Construct (SBC) as a temporary spacer for bone defect before bone transport |
| description |
INTRODUCTION:
Bone defect following resection of unhealthy
bone often become contracted and fill with
fibrous tissue. This will lead to resistance during
bone transport, fibrous tissue interposition and
skin invagination at the docking site. We report a
case where synthetic bone constructs (SBC) was
used as a temporary spacer to prevent valley
formation and soft tissue interposition during
bone transport. The SBC dissolved slowly and
thus allowing the bone to be transported with
minimal resistance and preventing fibrous tissue
formation in the bone gap.
METHODS:
A 30 year-old lady had a 4 cm bone gap
following resection of unhealthy bone for nonunion
following open grade IIIB distal tibia
fracture. The gap was filled with SBC and
ilizarov circular frame was assembled for bone
transport. SBC is a biodegradable
osteoconductive material made from calcium
phosphate based materials. It is manufactured by
Granulab (M) Sdn Bhd in a GMP accredited
factory and certified by British Standard Institute
(BSI). 5 cc of SBC was mix with 4 mls of bone
marrow aspirate in a cup. It is mix in a sterile OT
environment and put in a mold to make it into
small pellet. The mixture was allowed to be
hardened for 20 minutes before inserted into the
bone defect.
RESULTS:
The transported segment docks after 2 month.
There was no skin invagination and valley
formation. When the docking site was opened,
the gap was filled with partially dissolved
calcium phosphate. There was minimal soft
tissue interposition.
Figure 1: Plain radiograph post op, 1 month and
during docking
Figure 2: Clinical picture during mixing of SBC
with marrow aspirate, making pellet using mold
and opening of docking site showing calcium
phosphate material with minimal fibrous tissue
interposition.
DISCUSSIONS:
Although calcium phosphate has
osteoconductive property, we did not observe
any any bone formation at the gap although we
mix it with bone marrow aspirate. Calcium
Phosphate can also be used as an antibiotic
carrier for local slow release delivery following
resection of infected bone.
CONCLUSION:
Calcium phosphate is effective as a temporary
spacer to fill the gap during bone transport.
REFERENCES:
1. Thirumal M. Med J Malaysia.2001; 56:44-52
2. McKee M et al. J Orthop Trauma 201;.24:
483-490 |
| format |
Article |
| author |
AI, Muhamad Syafiz Mohd Yusof, Nazri Sulong, Ahmad Fadzli S, Mohd Aizat Azfar A, Nur Lidawati |
| author_facet |
AI, Muhamad Syafiz Mohd Yusof, Nazri Sulong, Ahmad Fadzli S, Mohd Aizat Azfar A, Nur Lidawati |
| author_sort |
AI, Muhamad Syafiz |
| title |
Calcium phosphate based Synthetic Bone Construct (SBC) as a temporary spacer for bone defect before bone transport |
| title_short |
Calcium phosphate based Synthetic Bone Construct (SBC) as a temporary spacer for bone defect before bone transport |
| title_full |
Calcium phosphate based Synthetic Bone Construct (SBC) as a temporary spacer for bone defect before bone transport |
| title_fullStr |
Calcium phosphate based Synthetic Bone Construct (SBC) as a temporary spacer for bone defect before bone transport |
| title_full_unstemmed |
Calcium phosphate based Synthetic Bone Construct (SBC) as a temporary spacer for bone defect before bone transport |
| title_sort |
calcium phosphate based synthetic bone construct (sbc) as a temporary spacer for bone defect before bone transport |
| publisher |
Malaysian Orthopaedic Association (MOA) |
| publishDate |
2018 |
| url |
http://irep.iium.edu.my/63989/ http://irep.iium.edu.my/63989/ http://irep.iium.edu.my/63989/1/Calcium%20Phosphate%20Based%20Synthetic%20Bone%20Construct%20%28SBC%29%20As%20A%20Temporary%20Spacer%20For%20Bone%20Defect%20Before%20Bone%20Transport.pdf |
| first_indexed |
2023-09-18T21:30:45Z |
| last_indexed |
2023-09-18T21:30:45Z |
| _version_ |
1777412493882163200 |