Cytotoxicity and antifungal properties of hydroxychavicol against trichophyton rubrum

Hydroxychavicol (HC) is a phenolic compound of betel leaf (Piper betle). It has been reported to have antifungal properties against dermatophytes including T. rubrum. The aim of this study was to identify the effects of the HC against T. rubrum. Broth dilution method was used to determine the mini...

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Main Authors:	Ridzuan, P. M., Mohamad, Nasir, Ismail, Salwani, Abdul Rahman, Nor Iza, Hamzah, Hairul Aini, Buyong, Zunariah, Mohd Hassan, Norazian, Baharudin, Roesnita
Format:	Article
Language:	English English English
Published:	International Islamic University Malaysia 2018
Subjects:	QR Microbiology QR180 Immunology
Online Access:	http://irep.iium.edu.my/64138/ http://irep.iium.edu.my/64138/ http://irep.iium.edu.my/64138/1/64138_Cytotoxicity%20and%20Antifungal%20Properties%20_article.pdf http://irep.iium.edu.my/64138/2/64138_Cytotoxicity%20and%20Antifungal%20Properties%20_scopus.pdf http://irep.iium.edu.my/64138/13/64138_Cytotoxicity%20and%20antifungal%20properties_WoS.pdf

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recordtype	eprints
spelling	iium-641382018-08-01T03:19:18Z http://irep.iium.edu.my/64138/ Cytotoxicity and antifungal properties of hydroxychavicol against trichophyton rubrum Ridzuan, P. M. Mohamad, Nasir Ismail, Salwani Abdul Rahman, Nor Iza Hamzah, Hairul Aini Buyong, Zunariah Mohd Hassan, Norazian Baharudin, Roesnita QR Microbiology QR180 Immunology Hydroxychavicol (HC) is a phenolic compound of betel leaf (Piper betle). It has been reported to have antifungal properties against dermatophytes including T. rubrum. The aim of this study was to identify the effects of the HC against T. rubrum. Broth dilution method was used to determine the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of the HC. Microscopic study of the treated fungus was done by transmission electron microscope (TEM). Cytotoxicity study using pre-adipocyte (3T3-L1) cell line was performed by means of MTT cell proliferation assay. The MIC and MFC results of the HC were both 0.49 µg/ml. Microscopic study revealed the destruction of the fungal cell wall and organelles. Cytotoxicity study showed HC to be non-toxic to the tested human cell line. In conclusion, HC may potentially be used as an alternative therapeutic agent against T. rubrum infections. International Islamic University Malaysia 2018-04-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/64138/1/64138_Cytotoxicity%20and%20Antifungal%20Properties%20_article.pdf application/pdf en http://irep.iium.edu.my/64138/2/64138_Cytotoxicity%20and%20Antifungal%20Properties%20_scopus.pdf application/pdf en http://irep.iium.edu.my/64138/13/64138_Cytotoxicity%20and%20antifungal%20properties_WoS.pdf Ridzuan, P. M. and Mohamad, Nasir and Ismail, Salwani and Abdul Rahman, Nor Iza and Hamzah, Hairul Aini and Buyong, Zunariah and Mohd Hassan, Norazian and Baharudin, Roesnita (2018) Cytotoxicity and antifungal properties of hydroxychavicol against trichophyton rubrum. International Medical Journal Malaysia, 17 (1). pp. 31-36. ISSN 1823-4631 http://iiumedic.net/imjm/v1/download/volume_17_no_1/Vol17-No1-p031036.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	QR Microbiology QR180 Immunology
spellingShingle	QR Microbiology QR180 Immunology Ridzuan, P. M. Mohamad, Nasir Ismail, Salwani Abdul Rahman, Nor Iza Hamzah, Hairul Aini Buyong, Zunariah Mohd Hassan, Norazian Baharudin, Roesnita Cytotoxicity and antifungal properties of hydroxychavicol against trichophyton rubrum
description	Hydroxychavicol (HC) is a phenolic compound of betel leaf (Piper betle). It has been reported to have antifungal properties against dermatophytes including T. rubrum. The aim of this study was to identify the effects of the HC against T. rubrum. Broth dilution method was used to determine the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of the HC. Microscopic study of the treated fungus was done by transmission electron microscope (TEM). Cytotoxicity study using pre-adipocyte (3T3-L1) cell line was performed by means of MTT cell proliferation assay. The MIC and MFC results of the HC were both 0.49 µg/ml. Microscopic study revealed the destruction of the fungal cell wall and organelles. Cytotoxicity study showed HC to be non-toxic to the tested human cell line. In conclusion, HC may potentially be used as an alternative therapeutic agent against T. rubrum infections.
format	Article
author	Ridzuan, P. M. Mohamad, Nasir Ismail, Salwani Abdul Rahman, Nor Iza Hamzah, Hairul Aini Buyong, Zunariah Mohd Hassan, Norazian Baharudin, Roesnita
author_facet	Ridzuan, P. M. Mohamad, Nasir Ismail, Salwani Abdul Rahman, Nor Iza Hamzah, Hairul Aini Buyong, Zunariah Mohd Hassan, Norazian Baharudin, Roesnita
author_sort	Ridzuan, P. M.
title	Cytotoxicity and antifungal properties of hydroxychavicol against trichophyton rubrum
title_short	Cytotoxicity and antifungal properties of hydroxychavicol against trichophyton rubrum
title_full	Cytotoxicity and antifungal properties of hydroxychavicol against trichophyton rubrum
title_fullStr	Cytotoxicity and antifungal properties of hydroxychavicol against trichophyton rubrum
title_full_unstemmed	Cytotoxicity and antifungal properties of hydroxychavicol against trichophyton rubrum
title_sort	cytotoxicity and antifungal properties of hydroxychavicol against trichophyton rubrum
publisher	International Islamic University Malaysia
publishDate	2018
url	http://irep.iium.edu.my/64138/ http://irep.iium.edu.my/64138/ http://irep.iium.edu.my/64138/1/64138_Cytotoxicity%20and%20Antifungal%20Properties%20_article.pdf http://irep.iium.edu.my/64138/2/64138_Cytotoxicity%20and%20Antifungal%20Properties%20_scopus.pdf http://irep.iium.edu.my/64138/13/64138_Cytotoxicity%20and%20antifungal%20properties_WoS.pdf
first_indexed	2023-09-18T21:30:58Z
last_indexed	2023-09-18T21:30:58Z
_version_	1777412507624800256

Cytotoxicity and antifungal properties of hydroxychavicol against trichophyton rubrum

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