Determinants of ocular symptoms in postmenopausal women with dry eye

Purpose: Dry eye in women is more prevalent postmenopause and alterations in sex hormone levels may be implicated. This study explored the relationship between serum concentration of sex hormones and dry eye symptoms and ocular surface signs. Methods: The study involved 46 postmenopausal women diag...

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Main Authors:	Stapleton, Fiona, Badarudin, Noor Ezailina, Jing, Jing You, Hampel, Ulrike, Eden, John, Raisin, Leanne, Williams, Jennifer, Chao, Cecilia, Blanka Golebiowski, Blanka
Format:	Article
Language:	English
Published:	Association Of Research In Vision Ophthalmology (United States) 2015
Subjects:	RE Ophthalmology
Online Access:	http://irep.iium.edu.my/64639/ http://irep.iium.edu.my/64639/ http://irep.iium.edu.my/64639/9/64639Determinants%20of%20ocular%20symptoms%20in%20postmenopaual%20women%20with%20dry%20eye..pdf

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recordtype	eprints
spelling	iium-646392018-07-30T01:43:45Z http://irep.iium.edu.my/64639/ Determinants of ocular symptoms in postmenopausal women with dry eye Stapleton, Fiona Badarudin, Noor Ezailina Jing, Jing You Hampel, Ulrike Eden, John Raisin, Leanne Williams, Jennifer Chao, Cecilia Blanka Golebiowski, Blanka RE Ophthalmology Purpose: Dry eye in women is more prevalent postmenopause and alterations in sex hormone levels may be implicated. This study explored the relationship between serum concentration of sex hormones and dry eye symptoms and ocular surface signs. Methods: The study involved 46 postmenopausal women diagnosed with non-Sjögrens dry eye and not taking hormone replacement therapy (mean age 64±5 years, 14±6 years since menopause). The following measurements were conducted at a single timepoint: Ocular symptoms (Ocular Surface Disease Index (OSDI) and Ocular Comfort Index (OCI)), tear function (non-invasive tear break-up time (NITBUT), tear osmolarity (TearLab), tear volume (Phenol Red Thread and Schirmer tests)), ocular surface staining and meibomian gland assessment using grading scales, ocular surface sensitivity (Cochet-Bonnet aesthesiometer) and venous blood collection. Serum concentrations of 17β-estradiol (E2), 3α-diol-G, DHEA-S and their ratios were determined using Enzyme-linked immunosorbent assay (ELISA). Univariate associations were examined using Spearman’s correlations and multiple linear regression analysis was subsequently used to examine predictors of dry eye symptoms. Results: Mean serum concentration of E2 was 10.8±19.7pg/ml, 2.10±2.77ng/ml of 3α-diol-G and 0.73±0.55μg/ml of DHEA-S. Mean symptoms scores were 27.0±18.1 (OSDI) and 40.3±8.4 (OCI). Only tear osmolarity and meibomian gland secretion quality were significant predictors in the OSDI model; this model explained 20% of the variance in the OSDI score (F(6, 39)=2.858, p=0.02, R2adj= 0.20). Eyelid vascularity and meibomian gland expressibility were significant predictors in the OCI dryness frequency model, explaining 29% of the variance in dryness frequency (F(6, 39)=4.015, p=0.003, R2adj=0.29). Although serum hormones were associated with symptoms scores on univariate correlations, E2, 3α-diol-G, DHEA-S or their ratios were not found to be significant predictors of ocular symptoms in the full multivariate model(p>0.05). Conclusions: Meibomian gland and lid variables are significant predictors of ocular symptoms in postmenopausal women with dry eye, but serum hormone levels were not shown to play a significant role in this study. These findings would suggest that meibomian gland disease underpins dry eye symptoms in this cohort and examination in a lager cohort is required may further elucidate the role of sex hormones in non-Sjögrens dry eye in postmenopausal women. Association Of Research In Vision Ophthalmology (United States) 2015-06 Article PeerReviewed application/pdf en http://irep.iium.edu.my/64639/9/64639Determinants%20of%20ocular%20symptoms%20in%20postmenopaual%20women%20with%20dry%20eye..pdf Stapleton, Fiona and Badarudin, Noor Ezailina and Jing, Jing You and Hampel, Ulrike and Eden, John and Raisin, Leanne and Williams, Jennifer and Chao, Cecilia and Blanka Golebiowski, Blanka (2015) Determinants of ocular symptoms in postmenopausal women with dry eye. Investigative Ophthalmology &; Visual Science,, 56 (7). p. 4473. ISSN 01460404 E-ISSN 1552-5783 https://iovs.arvojournals.org/article.aspx?articleid=2334421
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RE Ophthalmology
spellingShingle	RE Ophthalmology Stapleton, Fiona Badarudin, Noor Ezailina Jing, Jing You Hampel, Ulrike Eden, John Raisin, Leanne Williams, Jennifer Chao, Cecilia Blanka Golebiowski, Blanka Determinants of ocular symptoms in postmenopausal women with dry eye
description	Purpose: Dry eye in women is more prevalent postmenopause and alterations in sex hormone levels may be implicated. This study explored the relationship between serum concentration of sex hormones and dry eye symptoms and ocular surface signs. Methods: The study involved 46 postmenopausal women diagnosed with non-Sjögrens dry eye and not taking hormone replacement therapy (mean age 64±5 years, 14±6 years since menopause). The following measurements were conducted at a single timepoint: Ocular symptoms (Ocular Surface Disease Index (OSDI) and Ocular Comfort Index (OCI)), tear function (non-invasive tear break-up time (NITBUT), tear osmolarity (TearLab), tear volume (Phenol Red Thread and Schirmer tests)), ocular surface staining and meibomian gland assessment using grading scales, ocular surface sensitivity (Cochet-Bonnet aesthesiometer) and venous blood collection. Serum concentrations of 17β-estradiol (E2), 3α-diol-G, DHEA-S and their ratios were determined using Enzyme-linked immunosorbent assay (ELISA). Univariate associations were examined using Spearman’s correlations and multiple linear regression analysis was subsequently used to examine predictors of dry eye symptoms. Results: Mean serum concentration of E2 was 10.8±19.7pg/ml, 2.10±2.77ng/ml of 3α-diol-G and 0.73±0.55μg/ml of DHEA-S. Mean symptoms scores were 27.0±18.1 (OSDI) and 40.3±8.4 (OCI). Only tear osmolarity and meibomian gland secretion quality were significant predictors in the OSDI model; this model explained 20% of the variance in the OSDI score (F(6, 39)=2.858, p=0.02, R2adj= 0.20). Eyelid vascularity and meibomian gland expressibility were significant predictors in the OCI dryness frequency model, explaining 29% of the variance in dryness frequency (F(6, 39)=4.015, p=0.003, R2adj=0.29). Although serum hormones were associated with symptoms scores on univariate correlations, E2, 3α-diol-G, DHEA-S or their ratios were not found to be significant predictors of ocular symptoms in the full multivariate model(p>0.05). Conclusions: Meibomian gland and lid variables are significant predictors of ocular symptoms in postmenopausal women with dry eye, but serum hormone levels were not shown to play a significant role in this study. These findings would suggest that meibomian gland disease underpins dry eye symptoms in this cohort and examination in a lager cohort is required may further elucidate the role of sex hormones in non-Sjögrens dry eye in postmenopausal women.
format	Article
author	Stapleton, Fiona Badarudin, Noor Ezailina Jing, Jing You Hampel, Ulrike Eden, John Raisin, Leanne Williams, Jennifer Chao, Cecilia Blanka Golebiowski, Blanka
author_facet	Stapleton, Fiona Badarudin, Noor Ezailina Jing, Jing You Hampel, Ulrike Eden, John Raisin, Leanne Williams, Jennifer Chao, Cecilia Blanka Golebiowski, Blanka
author_sort	Stapleton, Fiona
title	Determinants of ocular symptoms in postmenopausal women with dry eye
title_short	Determinants of ocular symptoms in postmenopausal women with dry eye
title_full	Determinants of ocular symptoms in postmenopausal women with dry eye
title_fullStr	Determinants of ocular symptoms in postmenopausal women with dry eye
title_full_unstemmed	Determinants of ocular symptoms in postmenopausal women with dry eye
title_sort	determinants of ocular symptoms in postmenopausal women with dry eye
publisher	Association Of Research In Vision Ophthalmology (United States)
publishDate	2015
url	http://irep.iium.edu.my/64639/ http://irep.iium.edu.my/64639/ http://irep.iium.edu.my/64639/9/64639Determinants%20of%20ocular%20symptoms%20in%20postmenopaual%20women%20with%20dry%20eye..pdf
first_indexed	2023-09-18T21:31:44Z
last_indexed	2023-09-18T21:31:44Z
_version_	1777412555892850688

Determinants of ocular symptoms in postmenopausal women with dry eye

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