Dry eye symptoms and plasma hormone levels - A pilot study

Purpose: Dry eye symptoms are commonly reported par- ticularly in women post-menopause. This study explored the relationship between levels of plasma sex hormones and dry eye symptoms. Method: A cross-sectional, single visit study was conducted. The study involved a convenience s...

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Main Authors:	Stapleton, Fiona, Hampel, Ulrike, Badarudin, Noor Ezailina, Jalbert, Isabelle, Madigan, Michele, Golebiowski, Blanka
Format:	Article
Language:	English
Published:	Elsevier 2013
Subjects:	RE Ophthalmology
Online Access:	http://irep.iium.edu.my/64641/ http://irep.iium.edu.my/64641/ http://irep.iium.edu.my/64641/1/PIIS1367048413001458.pdf

id	iium-64641
recordtype	eprints
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RE Ophthalmology
spellingShingle	RE Ophthalmology Stapleton, Fiona Hampel, Ulrike Badarudin, Noor Ezailina Jalbert, Isabelle Madigan, Michele Golebiowski, Blanka Dry eye symptoms and plasma hormone levels - A pilot study
description	Purpose: Dry eye symptoms are commonly reported par- ticularly in women post-menopause. This study explored the relationship between levels of plasma sex hormones and dry eye symptoms. Method: A cross-sectional, single visit study was conducted. The study involved a convenience sample of 74 subjects without ocular surface disease, including 52 females (mean age 35.3 ± 13.4years, range 18.8-70.3) and 22 males (mean age 34.2 ± 13.8years, range 20.2-75.3). Subjects completed the Dry Eye Questionnaire (DEQ5) and numerical ratings of discomfort, dryness, foreign body (FB) sensation, burning and watering. Tear osmolarity (TearLab) and volume (Phenol Red Thread) were assessed. Venous blood was collected and plasma concentrations of oestradiol (E2) and total testosterone (TT) were determined using specific enzyme-linked immunosorbent assay. Associations were examined using Pear- son’s or Spearman’s correlations, and differences between groups were assessed using independent samples t-test or Mann-Whitney U test, as appropriate. Results: Mean group E2 concentration was 65.2 ± 50.9pg/ml in females and 40.7 ± 23.8pg/ml in males; TT concentration was 0.49 ± 0.29 and 4.3 ± 1.6ng/ml respectively. Symptom reporting was higher in females (p < 0.05). Tear volume was reduced in females (p = 0.02); there was no difference in tear osmolarity. In e8 Abstracts / Contact Lens & Anterior Eye 36 (2013) e1–e15 females, increased ocular symptoms (DEQ5, dryness, FB) was asso- ciated with higher levels of E2 (p < 0.05). Higher TT in females correlated with more FB sensation and lower tear volume (p < 0.05). No association was found between tear osmolarity and hormone levels in females. There was no association between age and ocular symptoms in either males or females. Conclusions: Higher circulating levels of sex steroid hormones appear to play a role in increased symptoms of dry eye in females, but not in males. This effect does not appear to be influenced by age. Evaluation of co-related factors such as levels of free testos- terone is warranted to further explore these relationships in the pathophysiology of dry eye.
format	Article
author	Stapleton, Fiona Hampel, Ulrike Badarudin, Noor Ezailina Jalbert, Isabelle Madigan, Michele Golebiowski, Blanka
author_facet	Stapleton, Fiona Hampel, Ulrike Badarudin, Noor Ezailina Jalbert, Isabelle Madigan, Michele Golebiowski, Blanka
author_sort	Stapleton, Fiona
title	Dry eye symptoms and plasma hormone levels - A pilot study
title_short	Dry eye symptoms and plasma hormone levels - A pilot study
title_full	Dry eye symptoms and plasma hormone levels - A pilot study
title_fullStr	Dry eye symptoms and plasma hormone levels - A pilot study
title_full_unstemmed	Dry eye symptoms and plasma hormone levels - A pilot study
title_sort	dry eye symptoms and plasma hormone levels - a pilot study
publisher	Elsevier
publishDate	2013
url	http://irep.iium.edu.my/64641/ http://irep.iium.edu.my/64641/ http://irep.iium.edu.my/64641/1/PIIS1367048413001458.pdf
first_indexed	2023-09-18T21:31:44Z
last_indexed	2023-09-18T21:31:44Z
_version_	1777412556164431872
spelling	iium-646412019-04-09T03:14:13Z http://irep.iium.edu.my/64641/ Dry eye symptoms and plasma hormone levels - A pilot study Stapleton, Fiona Hampel, Ulrike Badarudin, Noor Ezailina Jalbert, Isabelle Madigan, Michele Golebiowski, Blanka RE Ophthalmology Purpose: Dry eye symptoms are commonly reported par- ticularly in women post-menopause. This study explored the relationship between levels of plasma sex hormones and dry eye symptoms. Method: A cross-sectional, single visit study was conducted. The study involved a convenience sample of 74 subjects without ocular surface disease, including 52 females (mean age 35.3 ± 13.4years, range 18.8-70.3) and 22 males (mean age 34.2 ± 13.8years, range 20.2-75.3). Subjects completed the Dry Eye Questionnaire (DEQ5) and numerical ratings of discomfort, dryness, foreign body (FB) sensation, burning and watering. Tear osmolarity (TearLab) and volume (Phenol Red Thread) were assessed. Venous blood was collected and plasma concentrations of oestradiol (E2) and total testosterone (TT) were determined using specific enzyme-linked immunosorbent assay. Associations were examined using Pear- son’s or Spearman’s correlations, and differences between groups were assessed using independent samples t-test or Mann-Whitney U test, as appropriate. Results: Mean group E2 concentration was 65.2 ± 50.9pg/ml in females and 40.7 ± 23.8pg/ml in males; TT concentration was 0.49 ± 0.29 and 4.3 ± 1.6ng/ml respectively. Symptom reporting was higher in females (p < 0.05). Tear volume was reduced in females (p = 0.02); there was no difference in tear osmolarity. In e8 Abstracts / Contact Lens & Anterior Eye 36 (2013) e1–e15 females, increased ocular symptoms (DEQ5, dryness, FB) was asso- ciated with higher levels of E2 (p < 0.05). Higher TT in females correlated with more FB sensation and lower tear volume (p < 0.05). No association was found between tear osmolarity and hormone levels in females. There was no association between age and ocular symptoms in either males or females. Conclusions: Higher circulating levels of sex steroid hormones appear to play a role in increased symptoms of dry eye in females, but not in males. This effect does not appear to be influenced by age. Evaluation of co-related factors such as levels of free testos- terone is warranted to further explore these relationships in the pathophysiology of dry eye. Elsevier 2013-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/64641/1/PIIS1367048413001458.pdf Stapleton, Fiona and Hampel, Ulrike and Badarudin, Noor Ezailina and Jalbert, Isabelle and Madigan, Michele and Golebiowski, Blanka (2013) Dry eye symptoms and plasma hormone levels - A pilot study. Contact Lens and Anterior Eye, 36 (Supplement 2). e7-e7. ISSN 1367-0484 https://pdf.sciencedirectassets.com/272283/1-s2.0-S1367048413X00086/1-s2.0-S1367048413001458/main.pdf?x-amz-security-token=AgoJb3JpZ2luX2VjEIv%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEaCXVzLWVhc3QtMSJHMEUCIApnicP80xFFigwzLEaGnwdryFNrZDzMXbYBIOp2RZ%2FSAiEA2w6GSHS3fgyTPfs2qqaW31zK0DCpOFDFNphT5dVmDu8q2gMIUxACGgwwNTkwMDM1NDY4NjUiDMnHoaqdAo7cLppF%2Fiq3A4WWmXV6n%2Bg8QhUzRIrV5cJpai73UfxSX9GjXNG7HDsUavtWacTAL4V8REP%2FU%2BGbtz6mEInkP8lCFmyQtg0kubxgwphl%2BgkKmAumHr1kDMZg2euFK5ycS1in0mbG%2FNeScU5rBG8QrQtkDJBmBMoZ2GSxjS7XgUXlbumaYIf1BwNGa51E8rzC6RMuGuKXTELR7l79snDsWALD11zVkLBp8qGPFs1ZN3KSH9uJ9DgzJY4GxMHOpILjnxV3kLdkD%2FAksrCU6YwwFZBlDqW5w2D6F8hejo7zAfJY6n6fmeLv%2FOGmuPRIGdyrgaQKiI94RZsOC4PCufrAbV1StfbtVsjHzzlndROmNNQKBJenRZXl2mgR0g%2F7TSMUOfAU%2BmSjnHyptvC3lJcczYyMO6gA1q55%2F2%2FqmeDysTSXn4EvareAbYiUQFEyDo30vw25UkQ8mmNsfifkQd1cbCcRVoG49NMe3p%2FD21vUcU6c%2BI0rClFZOdy4FGYyqU0%2B7MG64qewcqXicWWqYIgyg1diX5xuaxypX57XIu9PTDJ2n4tdYdenKsfE%2BOTJ8k5Ajr%2B3kasevozjtLFFg9IF%2BwAwg%2F2v5QU6tAEkKkG2qRgQMJS59jRl2t69b%2F%2B4ndKlBBuy3mx06CCruoOESI8nDiJ9%2BjTefEdCZV5YsgH%2FlBBBS4lxWQ9QChq9GAZQUfwooTxO0X2XA%2Br713GbVdtiUCic4hQIWpc%2B4sQxJD%2BWG4Gus7IP0SrpymoCL5tRf6VcsHpjnBu%2FicoqW9zL4SwyhFX9FyoBkugsZKH2gEG9PSH%2FU7E3IHbjaA4FCYGlfK05WNAZ9zxqYR%2BlTQAIBo8%3D&AWSAccessKeyId=ASIAQ3PHCVTYQIRSI6OT&Expires=1554778967&Signature=l3yu7876L9BpUQDuB34FZ754cA0%3D&hash=fba1a60a1c9570e9ba99c80b47be781ccbb892e01a4db9f4efaef8dc33b7fba9&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S1367048413001458&tid=spdf-94659ce0-bfa8-4295-96e5-b47bbefa729a&sid=1bc41be4519b654bb45b1c37ea7c9a3b4096gxrqb&type=client

Dry eye symptoms and plasma hormone levels - A pilot study

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