The intra- and inter-grader reliability of Meibomian gland loss measurement

Previous work employed digital image analysis using a fully-automated computer software to quantify changes in MG, which is meibomian gland loss. However, semi-automated software is more favorable for clinical applications as it allows clinicians to manually delete undesired noise or artifacts. Purp...

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Main Authors:	Kamarul Zaman, Nur Aizzah Hanan, Che Azemin, Mohd Zulfaezal
Format:	Article
Language:	English
Published:	IIUM Press, International Islamic University Malaysia 2018
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/64668/ http://irep.iium.edu.my/64668/ http://irep.iium.edu.my/64668/1/64668_The%20intra-%20and%20inter-grader%20reliability.pdf

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spelling	iium-646682018-07-25T01:37:46Z http://irep.iium.edu.my/64668/ The intra- and inter-grader reliability of Meibomian gland loss measurement Kamarul Zaman, Nur Aizzah Hanan Che Azemin, Mohd Zulfaezal R Medicine (General) Previous work employed digital image analysis using a fully-automated computer software to quantify changes in MG, which is meibomian gland loss. However, semi-automated software is more favorable for clinical applications as it allows clinicians to manually delete undesired noise or artifacts. Purpose: To study the intra- and inter-grader reliability of meibomian gland loss (MGL) analysis using a semi-automated computer software. Methodology: This is a retrospective study as participants’ data were readily available from previous study. A total of 192 individual meibography images of meibomian gland (MG) from 48 subjects were loaded into ImageJ software. The MGL areas per total areas were manually traced and reported in percentage. The agreement within- and between-examiners were analyzed using intra-class correlation (ICC) and Bland-Altman plot. Results: ICC results showed only right and left upper eyelid were significantly correlated and showed excellent reliability for both intra- (RE: 0.944) (LE: 0.948) and inter-grader (RE: 0.831) (LE: 0.725) with p-value of less than 0.01. Meanwhile for the lower eyelid, the intra-grader result showed that only right lower eyelid had fair reliability with ICC of 0.525 (p = 0.005). The rest of the results showed poor reliability and the result was not significant. Conclusion: This method of measuring MGL area was only reliable in measuring the upper eyelid for both intra- and inter-grader. The definition of MG, and the interpretation of MGL area should be standardized. It is time consuming and might not be suitable to be used in routine eye examination IIUM Press, International Islamic University Malaysia 2018-07-05 Article PeerReviewed application/pdf en http://irep.iium.edu.my/64668/1/64668_The%20intra-%20and%20inter-grader%20reliability.pdf Kamarul Zaman, Nur Aizzah Hanan and Che Azemin, Mohd Zulfaezal (2018) The intra- and inter-grader reliability of Meibomian gland loss measurement. International Journal of Allied Health Sciences, 2 (1). pp. 226-233. E-ISSN 2600-8491 http://journals.iium.edu.my/ijahs/index.php/IJAHS/article/view/118
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Kamarul Zaman, Nur Aizzah Hanan Che Azemin, Mohd Zulfaezal The intra- and inter-grader reliability of Meibomian gland loss measurement
description	Previous work employed digital image analysis using a fully-automated computer software to quantify changes in MG, which is meibomian gland loss. However, semi-automated software is more favorable for clinical applications as it allows clinicians to manually delete undesired noise or artifacts. Purpose: To study the intra- and inter-grader reliability of meibomian gland loss (MGL) analysis using a semi-automated computer software. Methodology: This is a retrospective study as participants’ data were readily available from previous study. A total of 192 individual meibography images of meibomian gland (MG) from 48 subjects were loaded into ImageJ software. The MGL areas per total areas were manually traced and reported in percentage. The agreement within- and between-examiners were analyzed using intra-class correlation (ICC) and Bland-Altman plot. Results: ICC results showed only right and left upper eyelid were significantly correlated and showed excellent reliability for both intra- (RE: 0.944) (LE: 0.948) and inter-grader (RE: 0.831) (LE: 0.725) with p-value of less than 0.01. Meanwhile for the lower eyelid, the intra-grader result showed that only right lower eyelid had fair reliability with ICC of 0.525 (p = 0.005). The rest of the results showed poor reliability and the result was not significant. Conclusion: This method of measuring MGL area was only reliable in measuring the upper eyelid for both intra- and inter-grader. The definition of MG, and the interpretation of MGL area should be standardized. It is time consuming and might not be suitable to be used in routine eye examination
format	Article
author	Kamarul Zaman, Nur Aizzah Hanan Che Azemin, Mohd Zulfaezal
author_facet	Kamarul Zaman, Nur Aizzah Hanan Che Azemin, Mohd Zulfaezal
author_sort	Kamarul Zaman, Nur Aizzah Hanan
title	The intra- and inter-grader reliability of Meibomian gland loss measurement
title_short	The intra- and inter-grader reliability of Meibomian gland loss measurement
title_full	The intra- and inter-grader reliability of Meibomian gland loss measurement
title_fullStr	The intra- and inter-grader reliability of Meibomian gland loss measurement
title_full_unstemmed	The intra- and inter-grader reliability of Meibomian gland loss measurement
title_sort	intra- and inter-grader reliability of meibomian gland loss measurement
publisher	IIUM Press, International Islamic University Malaysia
publishDate	2018
url	http://irep.iium.edu.my/64668/ http://irep.iium.edu.my/64668/ http://irep.iium.edu.my/64668/1/64668_The%20intra-%20and%20inter-grader%20reliability.pdf
first_indexed	2023-09-18T21:31:46Z
last_indexed	2023-09-18T21:31:46Z
_version_	1777412558509047808

The intra- and inter-grader reliability of Meibomian gland loss measurement

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