Genetic polymorphisms of human transcription factor-7 like 2 (TCF7L2), β-defensin (DEFB1) and CD14 genes in nephrolithiasis patients
It is assumed that genetic factors play crucial role in nephrolithiasis. The present study was conducted to explore the role of Human Transcription Factor-7 like-2 (TCF7L2) β-defensin (DEFB1) and CD14 gene polymorphism in development and progression of nephrolithiasis. Methods: The genotypes of...
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Elsevier B.V.
2018
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iium-649362019-03-13T07:17:16Z http://irep.iium.edu.my/64936/ Genetic polymorphisms of human transcription factor-7 like 2 (TCF7L2), β-defensin (DEFB1) and CD14 genes in nephrolithiasis patients Mehdi, Wesen Adel Mehde, Atheer Awad Ahmad Raus, Raha Yusof, Faridah Zainal Abidin, Zaima Azira Ghazali, Hamid Abd Rahman, Azlina Özacar, Mahmud R Medicine (General) It is assumed that genetic factors play crucial role in nephrolithiasis. The present study was conducted to explore the role of Human Transcription Factor-7 like-2 (TCF7L2) β-defensin (DEFB1) and CD14 gene polymorphism in development and progression of nephrolithiasis. Methods: The genotypes of TCF7L2, DEFB1 and CD14 polymorphism were determined in 240 nephrolithiasis patients and 240 healthy controls by restriction digestion method of PCR. The levels of serum TCF7L2, DEFB1, CD14, uric acid and other biochemical parameters were measured both in nephrolithiasis patients and healthy control. Results: The patients and control groups showed 30% and 50% 1654 AA DEFB1 genotype respectively. The Allele frequency in case of patient’s group was 63.67% while in control group it was 36.33%. The mean serum DEFB1 levels of the patients and control groups attained were 115.66 and 239.43 pg/mL respectively. The allele frequency of TCF7L2 in patients and controls were 44.17% and 70.0% for C-allele, 55.83% and 30.00% for T-allele respectively. The mean of serum TCF7L2 levels were significantly decreased in patients compared to control group. Elsevier B.V. 2018-10-15 Article PeerReviewed application/pdf en http://irep.iium.edu.my/64936/7/64936_Genetic%20polymorphisms%20of%20human%20transcription_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/64936/13/64936_Genetic%20polymorphisms%20of%20human%20transcription.pdf Mehdi, Wesen Adel and Mehde, Atheer Awad and Ahmad Raus, Raha and Yusof, Faridah and Zainal Abidin, Zaima Azira and Ghazali, Hamid and Abd Rahman, Azlina and Özacar, Mahmud (2018) Genetic polymorphisms of human transcription factor-7 like 2 (TCF7L2), β-defensin (DEFB1) and CD14 genes in nephrolithiasis patients. International Journal of Biological Macromolecules, 118 (Part A). pp. 610-616. ISSN 0141-8130 https://www.sciencedirect.com/science/article/pii/S0141813018322669 10.1016/j.ijbiomac.2018.06.113 |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English English |
| topic |
R Medicine (General) |
| spellingShingle |
R Medicine (General) Mehdi, Wesen Adel Mehde, Atheer Awad Ahmad Raus, Raha Yusof, Faridah Zainal Abidin, Zaima Azira Ghazali, Hamid Abd Rahman, Azlina Özacar, Mahmud Genetic polymorphisms of human transcription factor-7 like 2 (TCF7L2), β-defensin (DEFB1) and CD14 genes in nephrolithiasis patients |
| description |
It is assumed that genetic factors play crucial role in nephrolithiasis. The
present study was conducted to explore the role of Human Transcription Factor-7 like-2
(TCF7L2) β-defensin (DEFB1) and CD14 gene polymorphism in development and
progression of nephrolithiasis.
Methods: The genotypes of TCF7L2, DEFB1 and CD14 polymorphism were determined in
240 nephrolithiasis patients and 240 healthy controls by restriction digestion method of PCR.
The levels of serum TCF7L2, DEFB1, CD14, uric acid and other biochemical parameters
were measured both in nephrolithiasis patients and healthy control.
Results: The patients and control groups showed 30% and 50% 1654 AA DEFB1 genotype
respectively. The Allele frequency in case of patient’s group was 63.67% while in control
group it was 36.33%. The mean serum DEFB1 levels of the patients and control groups
attained were 115.66 and 239.43 pg/mL respectively. The allele frequency of TCF7L2 in
patients and controls were 44.17% and 70.0% for C-allele, 55.83% and 30.00% for T-allele
respectively. The mean of serum TCF7L2 levels were significantly decreased in patients
compared to control group. |
| format |
Article |
| author |
Mehdi, Wesen Adel Mehde, Atheer Awad Ahmad Raus, Raha Yusof, Faridah Zainal Abidin, Zaima Azira Ghazali, Hamid Abd Rahman, Azlina Özacar, Mahmud |
| author_facet |
Mehdi, Wesen Adel Mehde, Atheer Awad Ahmad Raus, Raha Yusof, Faridah Zainal Abidin, Zaima Azira Ghazali, Hamid Abd Rahman, Azlina Özacar, Mahmud |
| author_sort |
Mehdi, Wesen Adel |
| title |
Genetic polymorphisms of human transcription factor-7 like 2
(TCF7L2), β-defensin (DEFB1) and CD14 genes in
nephrolithiasis patients |
| title_short |
Genetic polymorphisms of human transcription factor-7 like 2
(TCF7L2), β-defensin (DEFB1) and CD14 genes in
nephrolithiasis patients |
| title_full |
Genetic polymorphisms of human transcription factor-7 like 2
(TCF7L2), β-defensin (DEFB1) and CD14 genes in
nephrolithiasis patients |
| title_fullStr |
Genetic polymorphisms of human transcription factor-7 like 2
(TCF7L2), β-defensin (DEFB1) and CD14 genes in
nephrolithiasis patients |
| title_full_unstemmed |
Genetic polymorphisms of human transcription factor-7 like 2
(TCF7L2), β-defensin (DEFB1) and CD14 genes in
nephrolithiasis patients |
| title_sort |
genetic polymorphisms of human transcription factor-7 like 2
(tcf7l2), β-defensin (defb1) and cd14 genes in
nephrolithiasis patients |
| publisher |
Elsevier B.V. |
| publishDate |
2018 |
| url |
http://irep.iium.edu.my/64936/ http://irep.iium.edu.my/64936/ http://irep.iium.edu.my/64936/ http://irep.iium.edu.my/64936/7/64936_Genetic%20polymorphisms%20of%20human%20transcription_SCOPUS.pdf http://irep.iium.edu.my/64936/13/64936_Genetic%20polymorphisms%20of%20human%20transcription.pdf |
| first_indexed |
2023-09-18T21:32:09Z |
| last_indexed |
2023-09-18T21:32:09Z |
| _version_ |
1777412582590644224 |