Distinct role of kappa opioid receptor in attenuating relapse to morphine/methamphetamine (polydrug) dependence

A combination of 0.3 mg/kg buprenorphine and 1.0 mg/kg naltrexone treatment shows a promising result due to its ability to attenuate reinstatement (relapse) in morphine/methamphetamine (polydrug)-dependent mice in a conditioned place preference (CPP) model. This prompted us to identify which opioid...

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Main Authors:	Ridzwan, Irna Elina, Suhaimi, Maryam Saadah, Wasli, Nur Syafinaz, Kasmuri, Abdul Razak, Azzubaidi, Marwan Saad, Hashim, Ridzwan, Ahmed, Qamar Uddin, Ming, Long Chiau, Mohamed, Nornisah, Syd Mohmad Faudzi, Syed Mohd Syahmi
Format:	Article
Language:	English
Published:	University of Huddersfield Press 2017
Subjects:	RM300 Drugs and their action RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/64949/ http://irep.iium.edu.my/64949/ http://irep.iium.edu.my/64949/ http://irep.iium.edu.my/64949/3/Article.pdf

id	iium-64949
recordtype	eprints
spelling	iium-649492018-08-06T03:33:35Z http://irep.iium.edu.my/64949/ Distinct role of kappa opioid receptor in attenuating relapse to morphine/methamphetamine (polydrug) dependence Ridzwan, Irna Elina Suhaimi, Maryam Saadah Wasli, Nur Syafinaz Kasmuri, Abdul Razak Azzubaidi, Marwan Saad Hashim, Ridzwan Ahmed, Qamar Uddin Ming, Long Chiau Mohamed, Nornisah Syd Mohmad Faudzi, Syed Mohd Syahmi RM300 Drugs and their action RS Pharmacy and materia medica A combination of 0.3 mg/kg buprenorphine and 1.0 mg/kg naltrexone treatment shows a promising result due to its ability to attenuate reinstatement (relapse) in morphine/methamphetamine (polydrug)-dependent mice in a conditioned place preference (CPP) model. This prompted us to identify which opioid receptor that contributes to its anti-relapse activity. Using the same CPP model, 10 mg/kg nor-BNI (a selective kappa opioid receptor [KOR] antagonist) was used to evaluate the involvement of KOR in mediating relapse to polydrug dependence. By applying the immunohistochemistry (IHC) technique, the investigation was extended to the mice brain using KOR antibody (EPR18881), focusing on the brain regions that are abundant in KOR density. The results showed that nor-BNI alone failed to attenuate relapse to polydrug dependence. However, the IHC results proved that the number of KOR significantly increased in the striatum during reinstatement compared to post-conditioning (p <0.05). The KOR was significantly suppressed in the treatment group which strengthens the findings from the previous studies proving that the KOR plays an important role in mediating relapse to polydrug dependence. University of Huddersfield Press 2017 Article PeerReviewed application/pdf en http://irep.iium.edu.my/64949/3/Article.pdf Ridzwan, Irna Elina and Suhaimi, Maryam Saadah and Wasli, Nur Syafinaz and Kasmuri, Abdul Razak and Azzubaidi, Marwan Saad and Hashim, Ridzwan and Ahmed, Qamar Uddin and Ming, Long Chiau and Mohamed, Nornisah and Syd Mohmad Faudzi, Syed Mohd Syahmi (2017) Distinct role of kappa opioid receptor in attenuating relapse to morphine/methamphetamine (polydrug) dependence. British Journal of Pharmacy, 2 (2). S21-22S. ISSN 2058-8356 http://eprints.hud.ac.uk/id/eprint/34610/1/20_APS17_43%20Ridzwan.pdf 10.5920/bjpharm.2017.20.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RM300 Drugs and their action RS Pharmacy and materia medica
spellingShingle	RM300 Drugs and their action RS Pharmacy and materia medica Ridzwan, Irna Elina Suhaimi, Maryam Saadah Wasli, Nur Syafinaz Kasmuri, Abdul Razak Azzubaidi, Marwan Saad Hashim, Ridzwan Ahmed, Qamar Uddin Ming, Long Chiau Mohamed, Nornisah Syd Mohmad Faudzi, Syed Mohd Syahmi Distinct role of kappa opioid receptor in attenuating relapse to morphine/methamphetamine (polydrug) dependence
description	A combination of 0.3 mg/kg buprenorphine and 1.0 mg/kg naltrexone treatment shows a promising result due to its ability to attenuate reinstatement (relapse) in morphine/methamphetamine (polydrug)-dependent mice in a conditioned place preference (CPP) model. This prompted us to identify which opioid receptor that contributes to its anti-relapse activity. Using the same CPP model, 10 mg/kg nor-BNI (a selective kappa opioid receptor [KOR] antagonist) was used to evaluate the involvement of KOR in mediating relapse to polydrug dependence. By applying the immunohistochemistry (IHC) technique, the investigation was extended to the mice brain using KOR antibody (EPR18881), focusing on the brain regions that are abundant in KOR density. The results showed that nor-BNI alone failed to attenuate relapse to polydrug dependence. However, the IHC results proved that the number of KOR significantly increased in the striatum during reinstatement compared to post-conditioning (p <0.05). The KOR was significantly suppressed in the treatment group which strengthens the findings from the previous studies proving that the KOR plays an important role in mediating relapse to polydrug dependence.
format	Article
author	Ridzwan, Irna Elina Suhaimi, Maryam Saadah Wasli, Nur Syafinaz Kasmuri, Abdul Razak Azzubaidi, Marwan Saad Hashim, Ridzwan Ahmed, Qamar Uddin Ming, Long Chiau Mohamed, Nornisah Syd Mohmad Faudzi, Syed Mohd Syahmi
author_facet	Ridzwan, Irna Elina Suhaimi, Maryam Saadah Wasli, Nur Syafinaz Kasmuri, Abdul Razak Azzubaidi, Marwan Saad Hashim, Ridzwan Ahmed, Qamar Uddin Ming, Long Chiau Mohamed, Nornisah Syd Mohmad Faudzi, Syed Mohd Syahmi
author_sort	Ridzwan, Irna Elina
title	Distinct role of kappa opioid receptor in attenuating relapse to morphine/methamphetamine (polydrug) dependence
title_short	Distinct role of kappa opioid receptor in attenuating relapse to morphine/methamphetamine (polydrug) dependence
title_full	Distinct role of kappa opioid receptor in attenuating relapse to morphine/methamphetamine (polydrug) dependence
title_fullStr	Distinct role of kappa opioid receptor in attenuating relapse to morphine/methamphetamine (polydrug) dependence
title_full_unstemmed	Distinct role of kappa opioid receptor in attenuating relapse to morphine/methamphetamine (polydrug) dependence
title_sort	distinct role of kappa opioid receptor in attenuating relapse to morphine/methamphetamine (polydrug) dependence
publisher	University of Huddersfield Press
publishDate	2017
url	http://irep.iium.edu.my/64949/ http://irep.iium.edu.my/64949/ http://irep.iium.edu.my/64949/ http://irep.iium.edu.my/64949/3/Article.pdf
first_indexed	2023-09-18T21:32:10Z
last_indexed	2023-09-18T21:32:10Z
_version_	1777412583753515008

Distinct role of kappa opioid receptor in attenuating relapse to morphine/methamphetamine (polydrug) dependence

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