Overview of safety and efficacy of non-viral gene transfer in cartilage tissue engineering from the worldview of Islam
This paper examines the safety and efficacy of non-viral gene transfer in cartilage tissue engineering (TE) from the worldview of Islam. The first clinical trial treating adenosine deaminase deficient patients conducted in 1990 has triggered the development of gene transfer technology. The potenti...
| Main Authors: | , |
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| Format: | Article |
| Language: | English English |
| Published: |
2018
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/64972/ http://irep.iium.edu.my/64972/ http://irep.iium.edu.my/64972/1/64972_Overview%20of%20Safety.pdf http://irep.iium.edu.my/64972/7/64972_Overview%20of%20Safety_WOS.pdf |
| Summary: | This paper examines the safety and efficacy of non-viral gene transfer in cartilage tissue engineering (TE)
from the worldview of Islam. The first clinical trial treating adenosine deaminase deficient patients
conducted in 1990 has triggered the development of gene transfer technology. The potential of gene
transfer is further explored in TE field with the hope that it could prosper the regenerative medicine
application. However, ethical issues become important when it comes to application of new treatment
modalities, primarily in gene transfer because of genetic modification influences the basis of life - the DNA.
Besides ethical issue, the application of gene transfer in treating diseases also attract views from religious
context. The questions on the techniques to administer the gene in human, social acceptance of genetically
modified cell and adverse effects from it are still debatable and unresolved. Apart from that dilemma, both
safety and efficacy issues are raised due to the scientific uncertainty and social perception of the
technology. Despite countless number of encouraging findings and recommendations by the proponents of
the technology, gene transfer is currently available only in the research setting. The established guidelines
are used to complement and provide the necessary foundations in discussing the aspects involved in the
incorporation of gene transfer with cartilage TE. Relevant Islamic input are identified and aligned to those
particular guidelines. It is hoped that the integration of Islamic inputs in the existing guidelines could
suggest the safest approach in treating cartilage degenerative disease through gene transfer and TE. |
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