Overview of safety and efficacy of non-viral gene transfer in cartilage tissue engineering from the worldview of Islam

This paper examines the safety and efficacy of non-viral gene transfer in cartilage tissue engineering (TE) from the worldview of Islam. The first clinical trial treating adenosine deaminase deficient patients conducted in 1990 has triggered the development of gene transfer technology. The potenti...

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Main Authors:	Md Nazir, Noorhidayah, Sha'ban, Munirah
Format:	Article
Language:	English English
Published:	2018
Subjects:	BP190.5 Islamization of Knowledge R Medicine (General)
Online Access:	http://irep.iium.edu.my/64972/ http://irep.iium.edu.my/64972/ http://irep.iium.edu.my/64972/1/64972_Overview%20of%20Safety.pdf http://irep.iium.edu.my/64972/7/64972_Overview%20of%20Safety_WOS.pdf

id	iium-64972
recordtype	eprints
spelling	iium-649722019-01-24T07:17:45Z http://irep.iium.edu.my/64972/ Overview of safety and efficacy of non-viral gene transfer in cartilage tissue engineering from the worldview of Islam Md Nazir, Noorhidayah Sha'ban, Munirah BP190.5 Islamization of Knowledge R Medicine (General) This paper examines the safety and efficacy of non-viral gene transfer in cartilage tissue engineering (TE) from the worldview of Islam. The first clinical trial treating adenosine deaminase deficient patients conducted in 1990 has triggered the development of gene transfer technology. The potential of gene transfer is further explored in TE field with the hope that it could prosper the regenerative medicine application. However, ethical issues become important when it comes to application of new treatment modalities, primarily in gene transfer because of genetic modification influences the basis of life - the DNA. Besides ethical issue, the application of gene transfer in treating diseases also attract views from religious context. The questions on the techniques to administer the gene in human, social acceptance of genetically modified cell and adverse effects from it are still debatable and unresolved. Apart from that dilemma, both safety and efficacy issues are raised due to the scientific uncertainty and social perception of the technology. Despite countless number of encouraging findings and recommendations by the proponents of the technology, gene transfer is currently available only in the research setting. The established guidelines are used to complement and provide the necessary foundations in discussing the aspects involved in the incorporation of gene transfer with cartilage TE. Relevant Islamic input are identified and aligned to those particular guidelines. It is hoped that the integration of Islamic inputs in the existing guidelines could suggest the safest approach in treating cartilage degenerative disease through gene transfer and TE. 2018-07-18 Article PeerReviewed application/pdf en http://irep.iium.edu.my/64972/1/64972_Overview%20of%20Safety.pdf application/pdf en http://irep.iium.edu.my/64972/7/64972_Overview%20of%20Safety_WOS.pdf Md Nazir, Noorhidayah and Sha'ban, Munirah (2018) Overview of safety and efficacy of non-viral gene transfer in cartilage tissue engineering from the worldview of Islam. The International Medical Journal Malaysia, 17 (Special Issue 1). pp. 115-123. ISSN 1823-4631 http://iiumedic.net/imjm/v1/download/volume_17_special_issue_1/Pages-from-2WCIIv1-115-123.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	BP190.5 Islamization of Knowledge R Medicine (General)
spellingShingle	BP190.5 Islamization of Knowledge R Medicine (General) Md Nazir, Noorhidayah Sha'ban, Munirah Overview of safety and efficacy of non-viral gene transfer in cartilage tissue engineering from the worldview of Islam
description	This paper examines the safety and efficacy of non-viral gene transfer in cartilage tissue engineering (TE) from the worldview of Islam. The first clinical trial treating adenosine deaminase deficient patients conducted in 1990 has triggered the development of gene transfer technology. The potential of gene transfer is further explored in TE field with the hope that it could prosper the regenerative medicine application. However, ethical issues become important when it comes to application of new treatment modalities, primarily in gene transfer because of genetic modification influences the basis of life - the DNA. Besides ethical issue, the application of gene transfer in treating diseases also attract views from religious context. The questions on the techniques to administer the gene in human, social acceptance of genetically modified cell and adverse effects from it are still debatable and unresolved. Apart from that dilemma, both safety and efficacy issues are raised due to the scientific uncertainty and social perception of the technology. Despite countless number of encouraging findings and recommendations by the proponents of the technology, gene transfer is currently available only in the research setting. The established guidelines are used to complement and provide the necessary foundations in discussing the aspects involved in the incorporation of gene transfer with cartilage TE. Relevant Islamic input are identified and aligned to those particular guidelines. It is hoped that the integration of Islamic inputs in the existing guidelines could suggest the safest approach in treating cartilage degenerative disease through gene transfer and TE.
format	Article
author	Md Nazir, Noorhidayah Sha'ban, Munirah
author_facet	Md Nazir, Noorhidayah Sha'ban, Munirah
author_sort	Md Nazir, Noorhidayah
title	Overview of safety and efficacy of non-viral gene transfer in cartilage tissue engineering from the worldview of Islam
title_short	Overview of safety and efficacy of non-viral gene transfer in cartilage tissue engineering from the worldview of Islam
title_full	Overview of safety and efficacy of non-viral gene transfer in cartilage tissue engineering from the worldview of Islam
title_fullStr	Overview of safety and efficacy of non-viral gene transfer in cartilage tissue engineering from the worldview of Islam
title_full_unstemmed	Overview of safety and efficacy of non-viral gene transfer in cartilage tissue engineering from the worldview of Islam
title_sort	overview of safety and efficacy of non-viral gene transfer in cartilage tissue engineering from the worldview of islam
publishDate	2018
url	http://irep.iium.edu.my/64972/ http://irep.iium.edu.my/64972/ http://irep.iium.edu.my/64972/1/64972_Overview%20of%20Safety.pdf http://irep.iium.edu.my/64972/7/64972_Overview%20of%20Safety_WOS.pdf
first_indexed	2023-09-18T21:32:12Z
last_indexed	2023-09-18T21:32:12Z
_version_	1777412585204744192

Overview of safety and efficacy of non-viral gene transfer in cartilage tissue engineering from the worldview of Islam

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