Prevention of brain hypoperfusion-induced neurodegeneration in rat's hippocampus by black cumin fixed oil treatment

Introduction: The oil extract of black cumin seeds Nigella sativa (NSO) demonstrated considerable preservation of spatial cognitive functions in rats subjected to chronic brain hypoperfusion (CBH). The hippocampal CA1 region pyramidal cells are the earliest neurons suffering neurodegeneration follow...

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Main Authors:	Azzubaidi, Marwan Saad, Al-Ani, Imad Matloub Dally, Saxena, Anil Kumar, Faisal, Ghasak Ghazi
Format:	Article
Language:	English English English
Published:	International Islamic University Malaysia 2018
Subjects:	QM Human anatomy RB Pathology RC Internal medicine RM216 Diet Therapy. Clinical Nutrition
Online Access:	http://irep.iium.edu.my/65085/ http://irep.iium.edu.my/65085/ http://irep.iium.edu.my/65085/1/65085_Prevention%20of%20Brain%20Hypoperfusion-Induced%20_article.pdf http://irep.iium.edu.my/65085/2/65085_Prevention%20of%20Brain%20Hypoperfusion-Induced%20_scopus.pdf http://irep.iium.edu.my/65085/13/65085_Prevention%20of%20brain%20hypoperfusion-induced_WOS.pdf

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spelling	iium-650852018-10-08T03:23:36Z http://irep.iium.edu.my/65085/ Prevention of brain hypoperfusion-induced neurodegeneration in rat's hippocampus by black cumin fixed oil treatment Azzubaidi, Marwan Saad Al-Ani, Imad Matloub Dally Saxena, Anil Kumar Faisal, Ghasak Ghazi QM Human anatomy RB Pathology RC Internal medicine RM216 Diet Therapy. Clinical Nutrition Introduction: The oil extract of black cumin seeds Nigella sativa (NSO) demonstrated considerable preservation of spatial cognitive functions in rats subjected to chronic brain hypoperfusion (CBH). The hippocampal CA1 region pyramidal cells are the earliest neurons suffering neurodegeneration following CBH. Objective: The current study was devoted to assess the protective effects of Nigella sativa (NSO) treatment on CA1 hippocampal pyramidal cells of rats subjected to chronic brain hypoperfusion (CBH) that was achieved through permanent two vessel occlusion (2VO) procedure. Methods: Twenty four rats were equally divided into three groups; sham control, untreated 2VO and NSO treated group (2VO with daily oral NSO treatment. After the 10th postoperative week coronal sections of the hippocampus were collected for histopathological and electron microscopical examinations. Results: The number of viable pyramidal cells within CA1 hippocampal region in sham control and NSO treated groups was significantly higher than that of untreated 2VO group, while the difference was not significant when comparing the viable pyramidal cells number of sham control with NSO treated groups. Furthermore, 2VO group showed marked intracellular ultrastructural distortions that were less pronounced in NSO treated group. Conclusion: NSO displayed a robust potential to protect hippocampal pyramidal cells from CBH induced neurodegeneration putting forward its prospective neuroprotective activity against age related cognitive decline of Alzheimer's disease and vascular dementia. International Islamic University Malaysia 2018-04-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/65085/1/65085_Prevention%20of%20Brain%20Hypoperfusion-Induced%20_article.pdf application/pdf en http://irep.iium.edu.my/65085/2/65085_Prevention%20of%20Brain%20Hypoperfusion-Induced%20_scopus.pdf application/pdf en http://irep.iium.edu.my/65085/13/65085_Prevention%20of%20brain%20hypoperfusion-induced_WOS.pdf Azzubaidi, Marwan Saad and Al-Ani, Imad Matloub Dally and Saxena, Anil Kumar and Faisal, Ghasak Ghazi (2018) Prevention of brain hypoperfusion-induced neurodegeneration in rat's hippocampus by black cumin fixed oil treatment. International Medical Journal Malaysia, 17 (1). pp. 103-112. ISSN 1823-4631 http://iiumedic.net/imjm/v1/download/volume_17_no_1/Vol17-No1-p103112.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	QM Human anatomy RB Pathology RC Internal medicine RM216 Diet Therapy. Clinical Nutrition
spellingShingle	QM Human anatomy RB Pathology RC Internal medicine RM216 Diet Therapy. Clinical Nutrition Azzubaidi, Marwan Saad Al-Ani, Imad Matloub Dally Saxena, Anil Kumar Faisal, Ghasak Ghazi Prevention of brain hypoperfusion-induced neurodegeneration in rat's hippocampus by black cumin fixed oil treatment
description	Introduction: The oil extract of black cumin seeds Nigella sativa (NSO) demonstrated considerable preservation of spatial cognitive functions in rats subjected to chronic brain hypoperfusion (CBH). The hippocampal CA1 region pyramidal cells are the earliest neurons suffering neurodegeneration following CBH. Objective: The current study was devoted to assess the protective effects of Nigella sativa (NSO) treatment on CA1 hippocampal pyramidal cells of rats subjected to chronic brain hypoperfusion (CBH) that was achieved through permanent two vessel occlusion (2VO) procedure. Methods: Twenty four rats were equally divided into three groups; sham control, untreated 2VO and NSO treated group (2VO with daily oral NSO treatment. After the 10th postoperative week coronal sections of the hippocampus were collected for histopathological and electron microscopical examinations. Results: The number of viable pyramidal cells within CA1 hippocampal region in sham control and NSO treated groups was significantly higher than that of untreated 2VO group, while the difference was not significant when comparing the viable pyramidal cells number of sham control with NSO treated groups. Furthermore, 2VO group showed marked intracellular ultrastructural distortions that were less pronounced in NSO treated group. Conclusion: NSO displayed a robust potential to protect hippocampal pyramidal cells from CBH induced neurodegeneration putting forward its prospective neuroprotective activity against age related cognitive decline of Alzheimer's disease and vascular dementia.
format	Article
author	Azzubaidi, Marwan Saad Al-Ani, Imad Matloub Dally Saxena, Anil Kumar Faisal, Ghasak Ghazi
author_facet	Azzubaidi, Marwan Saad Al-Ani, Imad Matloub Dally Saxena, Anil Kumar Faisal, Ghasak Ghazi
author_sort	Azzubaidi, Marwan Saad
title	Prevention of brain hypoperfusion-induced neurodegeneration in rat's hippocampus by black cumin fixed oil treatment
title_short	Prevention of brain hypoperfusion-induced neurodegeneration in rat's hippocampus by black cumin fixed oil treatment
title_full	Prevention of brain hypoperfusion-induced neurodegeneration in rat's hippocampus by black cumin fixed oil treatment
title_fullStr	Prevention of brain hypoperfusion-induced neurodegeneration in rat's hippocampus by black cumin fixed oil treatment
title_full_unstemmed	Prevention of brain hypoperfusion-induced neurodegeneration in rat's hippocampus by black cumin fixed oil treatment
title_sort	prevention of brain hypoperfusion-induced neurodegeneration in rat's hippocampus by black cumin fixed oil treatment
publisher	International Islamic University Malaysia
publishDate	2018
url	http://irep.iium.edu.my/65085/ http://irep.iium.edu.my/65085/ http://irep.iium.edu.my/65085/1/65085_Prevention%20of%20Brain%20Hypoperfusion-Induced%20_article.pdf http://irep.iium.edu.my/65085/2/65085_Prevention%20of%20Brain%20Hypoperfusion-Induced%20_scopus.pdf http://irep.iium.edu.my/65085/13/65085_Prevention%20of%20brain%20hypoperfusion-induced_WOS.pdf
first_indexed	2023-09-18T21:32:20Z
last_indexed	2023-09-18T21:32:20Z
_version_	1777412594187894784

Prevention of brain hypoperfusion-induced neurodegeneration in rat's hippocampus by black cumin fixed oil treatment

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