Phytochemical constituents and pharmacological properties of Garcinia xanthochymus- a review

The purpose of this study was to determine the phytochemical constituents and pharmacological properties of Garcinia xanthochymus which is commonly known as gamboge, yellow mangosteen and false mangosteen. The phytochemicals constituents, pharmacological benefits and their mechanisms were previously...

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Main Authors:	Che Hassan, Nurul Khairina Najwa, Bakhtiar, M. Taher, Darnis, Deny Susanti
Format:	Article
Language:	English English English
Published:	Elsevier 2018
Subjects:	RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology
Online Access:	http://irep.iium.edu.my/65089/ http://irep.iium.edu.my/65089/ http://irep.iium.edu.my/65089/ http://irep.iium.edu.my/65089/7/65089%20Phytochemical%20constituents%20and%20pharmacological%20properties.pdf http://irep.iium.edu.my/65089/8/65089%20Phytochemical%20constituents%20and%20pharmacological%20properties%20SCOPUS.pdf http://irep.iium.edu.my/65089/19/65089_Phytochemical%20constituents%20and%20pharmacological_WOS.pdf

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spelling	iium-650892018-09-12T03:14:01Z http://irep.iium.edu.my/65089/ Phytochemical constituents and pharmacological properties of Garcinia xanthochymus- a review Che Hassan, Nurul Khairina Najwa Bakhtiar, M. Taher Darnis, Deny Susanti RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology The purpose of this study was to determine the phytochemical constituents and pharmacological properties of Garcinia xanthochymus which is commonly known as gamboge, yellow mangosteen and false mangosteen. The phytochemicals constituents, pharmacological benefits and their mechanisms were previously presented in a number of studies including in vitro and in vivo studies from published books, journals and articles. The literature used in this review were published between 1970 and 2017 and were available from databases such as Google Scholar, ScienceDirect, Scopus, PubMed, ProQuest and others. The chemical structures in this paper are drawn using ChemBio Ultra 14.0. G. xanthocymus contains many phytochemicals that can be extracted from its constituent parts; the bark, fruits, leaves, roots, twigs and seeds. The predominant extracted phytochemicals are xanthones, benzophenones, flavonoids, depsidones and isocoumarins. These phytochemicals contribute to the pharmacological activities of this plant as an antioxidant, antidiabetic, and for having Nerve Growth Factor potentiating,antimicrobial and cytotoxic activities. This species contains a broad range of phytochemicals with curative properties that can be greatly beneficial to man. Notably, this review focused on those studies of the pharmacological effects of this plant that were concentrated on by previous researchers. Thus, further study needs to be done on G. xanthocymus in order to unlock additional potential activities and to pinpoint the exact mechanisms of how these activities can be induced, leading to new drug discoveries which have fewer side effects. Elsevier 2018-10 Article PeerReviewed application/pdf en http://irep.iium.edu.my/65089/7/65089%20Phytochemical%20constituents%20and%20pharmacological%20properties.pdf application/pdf en http://irep.iium.edu.my/65089/8/65089%20Phytochemical%20constituents%20and%20pharmacological%20properties%20SCOPUS.pdf application/pdf en http://irep.iium.edu.my/65089/19/65089_Phytochemical%20constituents%20and%20pharmacological_WOS.pdf Che Hassan, Nurul Khairina Najwa and Bakhtiar, M. Taher and Darnis, Deny Susanti (2018) Phytochemical constituents and pharmacological properties of Garcinia xanthochymus- a review. Biomedicine & Pharmacotherapy, 106. pp. 1378-1389. ISSN 0753-3322 E-ISSN 1950-6007 https://www.journals.elsevier.com/biomedicine-and-pharmacotherapy 10.1016/j.biopha.2018.07.087
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology
spellingShingle	RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology Che Hassan, Nurul Khairina Najwa Bakhtiar, M. Taher Darnis, Deny Susanti Phytochemical constituents and pharmacological properties of Garcinia xanthochymus- a review
description	The purpose of this study was to determine the phytochemical constituents and pharmacological properties of Garcinia xanthochymus which is commonly known as gamboge, yellow mangosteen and false mangosteen. The phytochemicals constituents, pharmacological benefits and their mechanisms were previously presented in a number of studies including in vitro and in vivo studies from published books, journals and articles. The literature used in this review were published between 1970 and 2017 and were available from databases such as Google Scholar, ScienceDirect, Scopus, PubMed, ProQuest and others. The chemical structures in this paper are drawn using ChemBio Ultra 14.0. G. xanthocymus contains many phytochemicals that can be extracted from its constituent parts; the bark, fruits, leaves, roots, twigs and seeds. The predominant extracted phytochemicals are xanthones, benzophenones, flavonoids, depsidones and isocoumarins. These phytochemicals contribute to the pharmacological activities of this plant as an antioxidant, antidiabetic, and for having Nerve Growth Factor potentiating,antimicrobial and cytotoxic activities. This species contains a broad range of phytochemicals with curative properties that can be greatly beneficial to man. Notably, this review focused on those studies of the pharmacological effects of this plant that were concentrated on by previous researchers. Thus, further study needs to be done on G. xanthocymus in order to unlock additional potential activities and to pinpoint the exact mechanisms of how these activities can be induced, leading to new drug discoveries which have fewer side effects.
format	Article
author	Che Hassan, Nurul Khairina Najwa Bakhtiar, M. Taher Darnis, Deny Susanti
author_facet	Che Hassan, Nurul Khairina Najwa Bakhtiar, M. Taher Darnis, Deny Susanti
author_sort	Che Hassan, Nurul Khairina Najwa
title	Phytochemical constituents and pharmacological properties of Garcinia xanthochymus- a review
title_short	Phytochemical constituents and pharmacological properties of Garcinia xanthochymus- a review
title_full	Phytochemical constituents and pharmacological properties of Garcinia xanthochymus- a review
title_fullStr	Phytochemical constituents and pharmacological properties of Garcinia xanthochymus- a review
title_full_unstemmed	Phytochemical constituents and pharmacological properties of Garcinia xanthochymus- a review
title_sort	phytochemical constituents and pharmacological properties of garcinia xanthochymus- a review
publisher	Elsevier
publishDate	2018
url	http://irep.iium.edu.my/65089/ http://irep.iium.edu.my/65089/ http://irep.iium.edu.my/65089/ http://irep.iium.edu.my/65089/7/65089%20Phytochemical%20constituents%20and%20pharmacological%20properties.pdf http://irep.iium.edu.my/65089/8/65089%20Phytochemical%20constituents%20and%20pharmacological%20properties%20SCOPUS.pdf http://irep.iium.edu.my/65089/19/65089_Phytochemical%20constituents%20and%20pharmacological_WOS.pdf
first_indexed	2023-09-18T21:32:21Z
last_indexed	2023-09-18T21:32:21Z
_version_	1777412594498273280

Phytochemical constituents and pharmacological properties of Garcinia xanthochymus- a review

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