Tubulin and tau: Possible targets for diagnosis of Parkinson’s and Alzheimer’s diseases

Neurodegenerative diseases including Alzheimer’s disease (AD) and Parkinson’s disease (PD) are characterized by progressive neuronal loss and pathological accumulation of some proteins. Developing new biomarkers for both diseases is highly important for the early diagnosis and possible development o...

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Main Authors:	Salama, Mohamed, Shalash, Ali, Magdy, Alshimaa, Makar, Marianne, Roushdy, Tamer, Elbalkimy, Mahmoud, Elrassas, Hanan, Elkafrawy, Passent, Mohamed, Wael Mohamed Yousef, Abou Donia, Mohamed B.
Format:	Article
Language:	English English English
Published:	Public Library of Science 2018
Subjects:	RA Public aspects of medicine
Online Access:	http://irep.iium.edu.my/65206/ http://irep.iium.edu.my/65206/ http://irep.iium.edu.my/65206/ http://irep.iium.edu.my/65206/1/65206_Tubulin%20and%20tau.pdf http://irep.iium.edu.my/65206/2/65206_Tubulin%20and%20tau_SCOPUS.pdf http://irep.iium.edu.my/65206/3/65206_Tubulin%20and%20tau_WoS.pdf

id	iium-65206
recordtype	eprints
spelling	iium-652062018-08-20T01:40:09Z http://irep.iium.edu.my/65206/ Tubulin and tau: Possible targets for diagnosis of Parkinson’s and Alzheimer’s diseases Salama, Mohamed Shalash, Ali Magdy, Alshimaa Makar, Marianne Roushdy, Tamer Elbalkimy, Mahmoud Elrassas, Hanan Elkafrawy, Passent Mohamed, Wael Mohamed Yousef Abou Donia, Mohamed B. RA Public aspects of medicine Neurodegenerative diseases including Alzheimer’s disease (AD) and Parkinson’s disease (PD) are characterized by progressive neuronal loss and pathological accumulation of some proteins. Developing new biomarkers for both diseases is highly important for the early diagnosis and possible development of neuro-protective strategies. Serum antibodies (AIAs) against neuronal proteins are potential biomarkers for AD and PD that may be formed in response to their release into systemic circulation after brain damage. In the present study, two AIAs (tubulin and tau) were measured in sera of patients of PD and AD, compared to healthy controls. Results showed that both antibodies were elevated in patients with PD and AD compared to match controls. Curiously, the profile of elevation of antibodies was different in both diseases. In PD cases, tubulin and tau AIAs levels were similar. On the other hand, AD patients showed more elevation of tau AIAs compared to tubulin. Our current results suggested that AIAs panel could be able to identify cases with neuro-degeneration when compared with healthy subjects. More interestingly, it is possible to differentiate between PD and AD cases through identifying specific AIAs profile for each neurodegenerative states. Public Library of Science 2018-05-09 Article PeerReviewed application/pdf en http://irep.iium.edu.my/65206/1/65206_Tubulin%20and%20tau.pdf application/pdf en http://irep.iium.edu.my/65206/2/65206_Tubulin%20and%20tau_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/65206/3/65206_Tubulin%20and%20tau_WoS.pdf Salama, Mohamed and Shalash, Ali and Magdy, Alshimaa and Makar, Marianne and Roushdy, Tamer and Elbalkimy, Mahmoud and Elrassas, Hanan and Elkafrawy, Passent and Mohamed, Wael Mohamed Yousef and Abou Donia, Mohamed B. (2018) Tubulin and tau: Possible targets for diagnosis of Parkinson’s and Alzheimer’s diseases. PLoS ONE, 13 (5). ISSN 1932-6203 http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0196436&type=printable 10.1371/journal.pone.0196436
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RA Public aspects of medicine
spellingShingle	RA Public aspects of medicine Salama, Mohamed Shalash, Ali Magdy, Alshimaa Makar, Marianne Roushdy, Tamer Elbalkimy, Mahmoud Elrassas, Hanan Elkafrawy, Passent Mohamed, Wael Mohamed Yousef Abou Donia, Mohamed B. Tubulin and tau: Possible targets for diagnosis of Parkinson’s and Alzheimer’s diseases
description	Neurodegenerative diseases including Alzheimer’s disease (AD) and Parkinson’s disease (PD) are characterized by progressive neuronal loss and pathological accumulation of some proteins. Developing new biomarkers for both diseases is highly important for the early diagnosis and possible development of neuro-protective strategies. Serum antibodies (AIAs) against neuronal proteins are potential biomarkers for AD and PD that may be formed in response to their release into systemic circulation after brain damage. In the present study, two AIAs (tubulin and tau) were measured in sera of patients of PD and AD, compared to healthy controls. Results showed that both antibodies were elevated in patients with PD and AD compared to match controls. Curiously, the profile of elevation of antibodies was different in both diseases. In PD cases, tubulin and tau AIAs levels were similar. On the other hand, AD patients showed more elevation of tau AIAs compared to tubulin. Our current results suggested that AIAs panel could be able to identify cases with neuro-degeneration when compared with healthy subjects. More interestingly, it is possible to differentiate between PD and AD cases through identifying specific AIAs profile for each neurodegenerative states.
format	Article
author	Salama, Mohamed Shalash, Ali Magdy, Alshimaa Makar, Marianne Roushdy, Tamer Elbalkimy, Mahmoud Elrassas, Hanan Elkafrawy, Passent Mohamed, Wael Mohamed Yousef Abou Donia, Mohamed B.
author_facet	Salama, Mohamed Shalash, Ali Magdy, Alshimaa Makar, Marianne Roushdy, Tamer Elbalkimy, Mahmoud Elrassas, Hanan Elkafrawy, Passent Mohamed, Wael Mohamed Yousef Abou Donia, Mohamed B.
author_sort	Salama, Mohamed
title	Tubulin and tau: Possible targets for diagnosis of Parkinson’s and Alzheimer’s diseases
title_short	Tubulin and tau: Possible targets for diagnosis of Parkinson’s and Alzheimer’s diseases
title_full	Tubulin and tau: Possible targets for diagnosis of Parkinson’s and Alzheimer’s diseases
title_fullStr	Tubulin and tau: Possible targets for diagnosis of Parkinson’s and Alzheimer’s diseases
title_full_unstemmed	Tubulin and tau: Possible targets for diagnosis of Parkinson’s and Alzheimer’s diseases
title_sort	tubulin and tau: possible targets for diagnosis of parkinson’s and alzheimer’s diseases
publisher	Public Library of Science
publishDate	2018
url	http://irep.iium.edu.my/65206/ http://irep.iium.edu.my/65206/ http://irep.iium.edu.my/65206/ http://irep.iium.edu.my/65206/1/65206_Tubulin%20and%20tau.pdf http://irep.iium.edu.my/65206/2/65206_Tubulin%20and%20tau_SCOPUS.pdf http://irep.iium.edu.my/65206/3/65206_Tubulin%20and%20tau_WoS.pdf
first_indexed	2023-09-18T21:32:31Z
last_indexed	2023-09-18T21:32:31Z
_version_	1777412605512515584

Tubulin and tau: Possible targets for diagnosis of Parkinson’s and Alzheimer’s diseases

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