Agarwood (A. malaccensis) leaf as an alternative Halal source of anti-inflammatory compounds

The long-term consumption of aspirin and non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) which are used to control the symptoms of inflammation and pain have been reported to cause various side effects. Thus, natural compounds of various plant species including Aquilaria malaccensis have...

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Main Authors:	Zainurin, Nur Aimi Aliah, Hashim, Yumi Zuhanis Has-Yun, Eissa, Manar
Format:	Conference or Workshop Item
Language:	English
Published:	International Institute for Halal research and Training (INHART), IIUM 2018
Subjects:	TP248.13 Biotechnology
Online Access:	http://irep.iium.edu.my/65246/ http://irep.iium.edu.my/65246/ http://irep.iium.edu.my/65246/1/65246_Agarwood%20%28A.%20malaccensis%29%20Leaf.pdf

id	iium-65246
recordtype	eprints
spelling	iium-652462018-07-30T02:15:15Z http://irep.iium.edu.my/65246/ Agarwood (A. malaccensis) leaf as an alternative Halal source of anti-inflammatory compounds Zainurin, Nur Aimi Aliah Hashim, Yumi Zuhanis Has-Yun Eissa, Manar TP248.13 Biotechnology The long-term consumption of aspirin and non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) which are used to control the symptoms of inflammation and pain have been reported to cause various side effects. Thus, natural compounds of various plant species including Aquilaria malaccensis have been explored as an alternative therapeutic source for inflammation treatment with regard to their safety and effectiveness. Despite the accelerating rate on the research of agarwood leaf, the scientific evidences to elucidate the proclaimed pharmacological activities particularly anti-inflammatory activity are still limited. Therefore, it is the interest of this study to investigate the anti-inflammatory activity of A. malaccensis leaf extracted using Soxhlet method. Result showed that A. malaccensis leaf extract (ALEX) with ethanol (B) as solvent gave higher yield (mg/g) of 98.330 ± 4.113 (9.83% wt/wt) as compared to hexane (A); 24.039 ± 5.268 (2.40% wt/wt) after 6 hours of extraction. GCMS analysis revealed that 25 and 30 compounds were detected in ALEXA and ALEXB respectively with phytol as the major compound in both extracts. Subsequently, in-vitro study showed that the extracts exhibited a concentration dependent inhibition of protein (albumin) denaturation throughout the concentration range of 400-16 000 μg/ml tested. Further research is warranted to investigate the anti-inflammatory activities of A. malaccensis leaf extracts and their mechanism of action as a basis for future formulation of halal and natural anti-inflammatory agents. International Institute for Halal research and Training (INHART), IIUM 2018 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/65246/1/65246_Agarwood%20%28A.%20malaccensis%29%20Leaf.pdf Zainurin, Nur Aimi Aliah and Hashim, Yumi Zuhanis Has-Yun and Eissa, Manar (2018) Agarwood (A. malaccensis) leaf as an alternative Halal source of anti-inflammatory compounds. In: International Conference on Halal Innovation in Products and Services 2018 (i-CHIPS 2018), 13th-14th July 2018, Haat Yai, Songkhla, Thailand. http://halalinst.psu.ac.th/i-chips/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	TP248.13 Biotechnology
spellingShingle	TP248.13 Biotechnology Zainurin, Nur Aimi Aliah Hashim, Yumi Zuhanis Has-Yun Eissa, Manar Agarwood (A. malaccensis) leaf as an alternative Halal source of anti-inflammatory compounds
description	The long-term consumption of aspirin and non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) which are used to control the symptoms of inflammation and pain have been reported to cause various side effects. Thus, natural compounds of various plant species including Aquilaria malaccensis have been explored as an alternative therapeutic source for inflammation treatment with regard to their safety and effectiveness. Despite the accelerating rate on the research of agarwood leaf, the scientific evidences to elucidate the proclaimed pharmacological activities particularly anti-inflammatory activity are still limited. Therefore, it is the interest of this study to investigate the anti-inflammatory activity of A. malaccensis leaf extracted using Soxhlet method. Result showed that A. malaccensis leaf extract (ALEX) with ethanol (B) as solvent gave higher yield (mg/g) of 98.330 ± 4.113 (9.83% wt/wt) as compared to hexane (A); 24.039 ± 5.268 (2.40% wt/wt) after 6 hours of extraction. GCMS analysis revealed that 25 and 30 compounds were detected in ALEXA and ALEXB respectively with phytol as the major compound in both extracts. Subsequently, in-vitro study showed that the extracts exhibited a concentration dependent inhibition of protein (albumin) denaturation throughout the concentration range of 400-16 000 μg/ml tested. Further research is warranted to investigate the anti-inflammatory activities of A. malaccensis leaf extracts and their mechanism of action as a basis for future formulation of halal and natural anti-inflammatory agents.
format	Conference or Workshop Item
author	Zainurin, Nur Aimi Aliah Hashim, Yumi Zuhanis Has-Yun Eissa, Manar
author_facet	Zainurin, Nur Aimi Aliah Hashim, Yumi Zuhanis Has-Yun Eissa, Manar
author_sort	Zainurin, Nur Aimi Aliah
title	Agarwood (A. malaccensis) leaf as an alternative Halal source of anti-inflammatory compounds
title_short	Agarwood (A. malaccensis) leaf as an alternative Halal source of anti-inflammatory compounds
title_full	Agarwood (A. malaccensis) leaf as an alternative Halal source of anti-inflammatory compounds
title_fullStr	Agarwood (A. malaccensis) leaf as an alternative Halal source of anti-inflammatory compounds
title_full_unstemmed	Agarwood (A. malaccensis) leaf as an alternative Halal source of anti-inflammatory compounds
title_sort	agarwood (a. malaccensis) leaf as an alternative halal source of anti-inflammatory compounds
publisher	International Institute for Halal research and Training (INHART), IIUM
publishDate	2018
url	http://irep.iium.edu.my/65246/ http://irep.iium.edu.my/65246/ http://irep.iium.edu.my/65246/1/65246_Agarwood%20%28A.%20malaccensis%29%20Leaf.pdf
first_indexed	2023-09-18T21:32:35Z
last_indexed	2023-09-18T21:32:35Z
_version_	1777412609335623680

Agarwood (A. malaccensis) leaf as an alternative Halal source of anti-inflammatory compounds

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