Symmetric molecules with 1,4-triazole moieties as potent inhibitors of tumour-associated lactate dehydrogenase-A
A series of symmetric molecules incorporating aryl or pyridyl moieties as central core and 1,4-substituted triazoles as a side bridge was synthesised. The new compounds were investigated as lactate dehydro-genase (LDH, EC 1.1.1.27) inhibitors. The cancer associated LDHA isoform was inhibited with IC...
Main Authors: | Altamimi, Abdul Malek S., Alafeefy, Ahmed Mahmoud, Balode, Agnese, Vozny, Igor V., Pustenko, Aleksandrs, El Shikh, Mohey Eldin M., Alasmary, Fatmah Ali S., Abdel-Gawad, Sherif A., Žalubovskis, Raivis |
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Format: | Article |
Language: | English English |
Published: |
Taylor & Francis
2018
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Subjects: | |
Online Access: | http://irep.iium.edu.my/65282/ http://irep.iium.edu.my/65282/ http://irep.iium.edu.my/65282/ http://irep.iium.edu.my/65282/1/65282_Symmetric%20molecules%20with%201%2C4-triazole%20moieties%20_article.pdf http://irep.iium.edu.my/65282/2/65282_Symmetric%20molecules%20with%201%2C4-triazole%20moieties%20_scopus.pdf |
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