Signal peptide sequence analysis of selected protein sequences from Cryptosporidium parvum

Background and Objective: Studies on signal peptides remain little and lacking to Cryptosporidium. This study represents the first attempt to investigate selected putative protein sequences of Cryptosporidium parvum in its established genome database for signal peptide. Methods: Prediction analysis...

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Main Authors:	Barudin, Mohd Aiman, Md Isa, Muhammad Lokman, Mat Yusof, Afzan
Format:	Article
Language:	English English
Published:	Asian Network for Scientific Information 2018
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/65691/ http://irep.iium.edu.my/65691/ http://irep.iium.edu.my/65691/ http://irep.iium.edu.my/65691/1/65691_Signal%20peptide%20sequence%20analysis.pdf http://irep.iium.edu.my/65691/2/65691_Signal%20peptide%20sequence%20analysis_SCOPUS.pdf

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recordtype	eprints
spelling	iium-656912019-06-24T08:37:29Z http://irep.iium.edu.my/65691/ Signal peptide sequence analysis of selected protein sequences from Cryptosporidium parvum Barudin, Mohd Aiman Md Isa, Muhammad Lokman Mat Yusof, Afzan Q Science (General) Background and Objective: Studies on signal peptides remain little and lacking to Cryptosporidium. This study represents the first attempt to investigate selected putative protein sequences of Cryptosporidium parvum in its established genome database for signal peptide. Methods: Prediction analysis of protein sequences and identification of signal peptides on this parasite were analysed by SignalP 4.1 server. A total of 100 protein sequences were randomly selected and analysed, of which 6 (6%) corresponded to be predicted as signal peptide sequences. Results: Based on the comparison of sequences with database protein sequences in GenBank NCBI, almost all protein sequences were highly conserved with other protein sequences from different species of Cryptosporidium. Considering the secretory proteins in Cryptosporidium, several virulence protein sequences of this parasite may also show presence of N-terminal signal peptide or not. Conclusions: Hence, further studies need to be carried out for identification of N-terminal signal peptide function in Cryptosporidium for facilitating its virulence and pathogenesis pathway. Asian Network for Scientific Information 2018 Article PeerReviewed application/pdf en http://irep.iium.edu.my/65691/1/65691_Signal%20peptide%20sequence%20analysis.pdf application/pdf en http://irep.iium.edu.my/65691/2/65691_Signal%20peptide%20sequence%20analysis_SCOPUS.pdf Barudin, Mohd Aiman and Md Isa, Muhammad Lokman and Mat Yusof, Afzan (2018) Signal peptide sequence analysis of selected protein sequences from Cryptosporidium parvum. Trends in Bioinformatics, 11 (1). pp. 33-43. ISSN 1994-7941 E-ISSN 2077-2254 http://docsdrive.com/pdfs/ansinet/tb/2018/33-43.pdf 10.3923/tb.2018.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	Q Science (General)
spellingShingle	Q Science (General) Barudin, Mohd Aiman Md Isa, Muhammad Lokman Mat Yusof, Afzan Signal peptide sequence analysis of selected protein sequences from Cryptosporidium parvum
description	Background and Objective: Studies on signal peptides remain little and lacking to Cryptosporidium. This study represents the first attempt to investigate selected putative protein sequences of Cryptosporidium parvum in its established genome database for signal peptide. Methods: Prediction analysis of protein sequences and identification of signal peptides on this parasite were analysed by SignalP 4.1 server. A total of 100 protein sequences were randomly selected and analysed, of which 6 (6%) corresponded to be predicted as signal peptide sequences. Results: Based on the comparison of sequences with database protein sequences in GenBank NCBI, almost all protein sequences were highly conserved with other protein sequences from different species of Cryptosporidium. Considering the secretory proteins in Cryptosporidium, several virulence protein sequences of this parasite may also show presence of N-terminal signal peptide or not. Conclusions: Hence, further studies need to be carried out for identification of N-terminal signal peptide function in Cryptosporidium for facilitating its virulence and pathogenesis pathway.
format	Article
author	Barudin, Mohd Aiman Md Isa, Muhammad Lokman Mat Yusof, Afzan
author_facet	Barudin, Mohd Aiman Md Isa, Muhammad Lokman Mat Yusof, Afzan
author_sort	Barudin, Mohd Aiman
title	Signal peptide sequence analysis of selected protein sequences from Cryptosporidium parvum
title_short	Signal peptide sequence analysis of selected protein sequences from Cryptosporidium parvum
title_full	Signal peptide sequence analysis of selected protein sequences from Cryptosporidium parvum
title_fullStr	Signal peptide sequence analysis of selected protein sequences from Cryptosporidium parvum
title_full_unstemmed	Signal peptide sequence analysis of selected protein sequences from Cryptosporidium parvum
title_sort	signal peptide sequence analysis of selected protein sequences from cryptosporidium parvum
publisher	Asian Network for Scientific Information
publishDate	2018
url	http://irep.iium.edu.my/65691/ http://irep.iium.edu.my/65691/ http://irep.iium.edu.my/65691/ http://irep.iium.edu.my/65691/1/65691_Signal%20peptide%20sequence%20analysis.pdf http://irep.iium.edu.my/65691/2/65691_Signal%20peptide%20sequence%20analysis_SCOPUS.pdf
first_indexed	2023-09-18T21:33:12Z
last_indexed	2023-09-18T21:33:12Z
_version_	1777412648376205312

Signal peptide sequence analysis of selected protein sequences from Cryptosporidium parvum

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