Improvement of dissolution properties of albendazole fromdifferent methods of solid dispersion
Poor aqueous solubility of drugs results in poor absorption and bioavailability. The objective of solid dispersion technology is to increase the dissolution properties of highly lipophilic drugs, by using different hydrophilic carriers thereby improving their bioavailability. Thi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2018
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/66403/ http://irep.iium.edu.my/66403/1/Dr.%20Helal-JDDT_Published%20article.pdf |
| Summary: | Poor aqueous solubility of drugs results in poor absorption and bioavailability. The objective of solid dispersion technology is to
increase the dissolution properties of highly lipophilic drugs, by using different hydrophilic carriers thereby improving their
bioavailability. This technology is useful for enhancing the dissolution, absorption and therapeutic efficacy of drugs in dosage forms.
Albendazole is a broad-spectrum antihelmintic agent used for the treatment of a variety of parasitic worm infestations. It is
practically insoluble in water but slightly soluble in solvents like chloroform, methanol, ethyl acetate, and acetonitrile. The aim of
our study was to improve the dissolution profile of albendazole using HPMC K 100 LV, Kollidon VA64 and Mannitol as carriers by
solid dispersion techniques. From the prepared solid dispersion, formulation code CSF5 showed better result where carrier was
HMPC K 100 LV at 1:10 ratio in solvent evaporation method. The HPMC K 100 LV showed better result for both kneading and
solvent evaporation methods. Moreover, among the method employed, solvent evaporation method showed better solubility of drug
at 60 min also at 1:10 ratio which was 78.86%. Results indicated that current formulation of solid dispersion is a promising approach
for enhancing drug solubility and dissolution. |
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