Leptin hormone changes in patients with poly cystic ovarian syndrome treated by aromatase inhibitors

In the last few years a novel scope suggest the use of Aromatase inhibitors in women with PCOS (one of the most cause of anovulatory infertility) for treating the whole spectrum of reproductive, endocrine abnormalities usually found in such subject, particularly those who are classified as Clomiphen...

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Main Authors:	Al Omari, Wafa, Mustafa Al-Ahmad, Basma Ezzat
Format:	Book
Language:	English
Published:	IIUM Press, International Islamic University Malaysia 2018
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/66540/ http://irep.iium.edu.my/66540/1/66540_Leptin%20hormone%20changes%20in%20patients%20with%20poly%20cystic%20ovarian%20syndrome%20treated%20by%20aromatase%20inhibitors.pdf

id	iium-66540
recordtype	eprints
spelling	iium-665402019-10-14T04:10:41Z http://irep.iium.edu.my/66540/ Leptin hormone changes in patients with poly cystic ovarian syndrome treated by aromatase inhibitors Al Omari, Wafa Mustafa Al-Ahmad, Basma Ezzat R Medicine (General) In the last few years a novel scope suggest the use of Aromatase inhibitors in women with PCOS (one of the most cause of anovulatory infertility) for treating the whole spectrum of reproductive, endocrine abnormalities usually found in such subject, particularly those who are classified as Clomiphene citrate resistant patients. On the other hand the discovery of Leptin hormone,a cytokine secreted by adipocytes, (167-amino acid peptide product of ob gene), generated an extraordinary interest in the understanding of the relationship between metabolic status and the neuroendocrine system, in particular, the neuroendocrine regulation of reproduction. Moreover, leptin was thought to be involved in the regulation of implantation and has also been indirectly associated with steroid production in the ovary and in the regulation of progesterone production by granulosa cells.Brannian et al. (1999) thought that Leptin is also involved in the female fertility, especially in pubertal development. Although the exact mechanisms and nteractions with sex steroids are not yet fully established, it is clear that Leptin plays a role as an endocrine mediator in sexual development and reproduction. The concept has emerged that a normal Leptin secretion is a prerequisite for normal reproduction function, Leptin acting as a permissive factor since initiation and maintenance of normal reproductive capacity necessitate adequate metabolic conditions . Most of the researchers in the use of Aromatase Inhibitors for ovulation induction in patient with PCOS has been carried out relatively recently and some theories are still controversial, I have therefore, summarized the available experimental evidence in this introduction and explained the reasons for the development of the study reported in this book. IIUM Press, International Islamic University Malaysia 2018 Book PeerReviewed application/pdf en http://irep.iium.edu.my/66540/1/66540_Leptin%20hormone%20changes%20in%20patients%20with%20poly%20cystic%20ovarian%20syndrome%20treated%20by%20aromatase%20inhibitors.pdf Al Omari, Wafa and Mustafa Al-Ahmad, Basma Ezzat (2018) Leptin hormone changes in patients with poly cystic ovarian syndrome treated by aromatase inhibitors. IIUM Press, International Islamic University Malaysia, Kuala Lumpur, Malaysia. ISBN 9789674189778
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Al Omari, Wafa Mustafa Al-Ahmad, Basma Ezzat Leptin hormone changes in patients with poly cystic ovarian syndrome treated by aromatase inhibitors
description	In the last few years a novel scope suggest the use of Aromatase inhibitors in women with PCOS (one of the most cause of anovulatory infertility) for treating the whole spectrum of reproductive, endocrine abnormalities usually found in such subject, particularly those who are classified as Clomiphene citrate resistant patients. On the other hand the discovery of Leptin hormone,a cytokine secreted by adipocytes, (167-amino acid peptide product of ob gene), generated an extraordinary interest in the understanding of the relationship between metabolic status and the neuroendocrine system, in particular, the neuroendocrine regulation of reproduction. Moreover, leptin was thought to be involved in the regulation of implantation and has also been indirectly associated with steroid production in the ovary and in the regulation of progesterone production by granulosa cells.Brannian et al. (1999) thought that Leptin is also involved in the female fertility, especially in pubertal development. Although the exact mechanisms and nteractions with sex steroids are not yet fully established, it is clear that Leptin plays a role as an endocrine mediator in sexual development and reproduction. The concept has emerged that a normal Leptin secretion is a prerequisite for normal reproduction function, Leptin acting as a permissive factor since initiation and maintenance of normal reproductive capacity necessitate adequate metabolic conditions . Most of the researchers in the use of Aromatase Inhibitors for ovulation induction in patient with PCOS has been carried out relatively recently and some theories are still controversial, I have therefore, summarized the available experimental evidence in this introduction and explained the reasons for the development of the study reported in this book.
format	Book
author	Al Omari, Wafa Mustafa Al-Ahmad, Basma Ezzat
author_facet	Al Omari, Wafa Mustafa Al-Ahmad, Basma Ezzat
author_sort	Al Omari, Wafa
title	Leptin hormone changes in patients with poly cystic ovarian syndrome treated by aromatase inhibitors
title_short	Leptin hormone changes in patients with poly cystic ovarian syndrome treated by aromatase inhibitors
title_full	Leptin hormone changes in patients with poly cystic ovarian syndrome treated by aromatase inhibitors
title_fullStr	Leptin hormone changes in patients with poly cystic ovarian syndrome treated by aromatase inhibitors
title_full_unstemmed	Leptin hormone changes in patients with poly cystic ovarian syndrome treated by aromatase inhibitors
title_sort	leptin hormone changes in patients with poly cystic ovarian syndrome treated by aromatase inhibitors
publisher	IIUM Press, International Islamic University Malaysia
publishDate	2018
url	http://irep.iium.edu.my/66540/ http://irep.iium.edu.my/66540/1/66540_Leptin%20hormone%20changes%20in%20patients%20with%20poly%20cystic%20ovarian%20syndrome%20treated%20by%20aromatase%20inhibitors.pdf
first_indexed	2023-09-18T21:34:29Z
last_indexed	2023-09-18T21:34:29Z
_version_	1777412729057837056

Leptin hormone changes in patients with poly cystic ovarian syndrome treated by aromatase inhibitors

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