Trends and patterns of analgesic prescribing in Malaysian public hospitals from 2010 to 2016 : Tramadol predominately used
Purpose: To examine the trends of analgesic prescribing at public tertiary hospital outpatient settings and explore the patterns of their utilization in NSAIDs, tramadol and opioid patients. Patients and methods: This cross sectional study was conducted from 2010 to 2016 using the prescription da...
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iium-66546 |
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eprints |
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iium-665462019-01-24T08:17:00Z http://irep.iium.edu.my/66546/ Trends and patterns of analgesic prescribing in Malaysian public hospitals from 2010 to 2016 : Tramadol predominately used Zin, Che Suraya Mohamed Nazar, Nor Ilyani Ab Rahman, Norny Syafinaz Alias, Nor Elina Ahmad, Wan Rohaidah Rani, Nurul Sahida Cardosa, Mary Suma Ng, Kim Swan Ye, Felicia Loh RM Therapeutics. Pharmacology RM300 Drugs and their action RS Pharmacy and materia medica Purpose: To examine the trends of analgesic prescribing at public tertiary hospital outpatient settings and explore the patterns of their utilization in NSAIDs, tramadol and opioid patients. Patients and methods: This cross sectional study was conducted from 2010 to 2016 using the prescription databases of two tertiary hospitals in Malaysia. Prescriptions for nine NSAIDs (ketoprofen, diclofenac, celecoxib, etoricoxib, ibuprofen, indomethacin, meloxicam, mefenamic acid and naproxen), tramadol and five other opioids (morphine, fentanyl, oxycodone, dihydrocodeine, and buprenorphine) were included in this study. Annual number of patients and prescriptions were measured in repeat cross sectional estimates. Descriptive statistics and linear trend analysis were performed using Stata v13. Results: A total of 192747 analgesic prescriptions of the nine NSAIDs, tramadol, and five other opioids were prescribed for 97227 patients (51.8% NSAIDs patients, 46.6% tramadol patients, and 1.7% opioid patients) from 2010 to 2016. Tramadol (37.9%, n = 72999) was the most frequently prescribed analgesic followed by ketoprofen (17.5%, n=33793), diclofenac (16.2%, n = 31180), celecoxib (12.2%, n =23487), and other NSAIDs (<4.5%). All the analgesics were increased over time except for meloxicam, indomethacin, and mefenamic acid. Opioids, primarily morphine (2.2%, n = 4021) and oxycodone (0.5%, n = 1049), were prescribed the least but the rate of increase was the highest. Conclusion: Tramadol was the most frequently prescribed analgesic at hospital outpatient settings in Malaysia. Opioids were prescribed the least but noted the highest increase in utilization. Dove Press Ltd 2018-09-20 Article PeerReviewed application/pdf en http://irep.iium.edu.my/66546/1/Zin_tramadol_f_jpr-164774-trends-and-patterns-of-analgesic-prescribing-in-malaysian-pu-091918_44589.pdf application/pdf en http://irep.iium.edu.my/66546/8/66546_Trends%20and%20patterns%20of%20analgesic%20prescribing%20in%20Malaysian%20public%20hospitals%20from%202010%20to%202016_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/66546/14/66546_Trends%20and%20patterns%20of%20analgesic%20prescribing%20in%20Malaysian%20public%20hospitals%20from%202010%20to%202016%20tramadol%20predominately%20used_WOS.pdf Zin, Che Suraya and Mohamed Nazar, Nor Ilyani and Ab Rahman, Norny Syafinaz and Alias, Nor Elina and Ahmad, Wan Rohaidah and Rani, Nurul Sahida and Cardosa, Mary Suma and Ng, Kim Swan and Ye, Felicia Loh (2018) Trends and patterns of analgesic prescribing in Malaysian public hospitals from 2010 to 2016 : Tramadol predominately used. Journal of Pain Research, 11. pp. 1959-1966. ISSN 1178-7090 https://www.dovepress.com/trends-and-patterns-of-analgesic-prescribing-in-malaysian-public-hospi-peer-reviewed-article-JPR 10.2147/JPR.S164774 |
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Digital Repository |
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Local University |
| institution |
International Islamic University Malaysia |
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IIUM Repository |
| collection |
Online Access |
| language |
English English English |
| topic |
RM Therapeutics. Pharmacology RM300 Drugs and their action RS Pharmacy and materia medica |
| spellingShingle |
RM Therapeutics. Pharmacology RM300 Drugs and their action RS Pharmacy and materia medica Zin, Che Suraya Mohamed Nazar, Nor Ilyani Ab Rahman, Norny Syafinaz Alias, Nor Elina Ahmad, Wan Rohaidah Rani, Nurul Sahida Cardosa, Mary Suma Ng, Kim Swan Ye, Felicia Loh Trends and patterns of analgesic prescribing in Malaysian public hospitals from 2010 to 2016 : Tramadol predominately used |
| description |
Purpose: To examine the trends of analgesic prescribing at public tertiary hospital outpatient settings and explore the patterns of their utilization in NSAIDs, tramadol and opioid patients.
Patients and methods: This cross sectional study was conducted from 2010 to 2016 using the prescription databases of two tertiary hospitals in Malaysia. Prescriptions for nine NSAIDs (ketoprofen, diclofenac, celecoxib, etoricoxib, ibuprofen, indomethacin, meloxicam, mefenamic acid and naproxen), tramadol and five other opioids (morphine, fentanyl, oxycodone, dihydrocodeine, and buprenorphine) were included in this study. Annual number of patients and prescriptions were measured in repeat cross sectional estimates. Descriptive statistics and linear trend analysis were performed using Stata v13.
Results: A total of 192747 analgesic prescriptions of the nine NSAIDs, tramadol, and five other opioids were prescribed for 97227 patients (51.8% NSAIDs patients, 46.6% tramadol patients, and 1.7% opioid patients) from 2010 to 2016. Tramadol (37.9%, n = 72999) was the most frequently prescribed analgesic followed by ketoprofen (17.5%, n=33793), diclofenac (16.2%, n = 31180), celecoxib (12.2%, n =23487), and other NSAIDs (<4.5%). All the analgesics were increased over time except for meloxicam, indomethacin, and mefenamic acid. Opioids, primarily morphine (2.2%, n = 4021) and oxycodone (0.5%, n = 1049), were prescribed the least but the rate of increase was the highest.
Conclusion: Tramadol was the most frequently prescribed analgesic at hospital outpatient settings in Malaysia. Opioids were prescribed the least but noted the highest increase in utilization. |
| format |
Article |
| author |
Zin, Che Suraya Mohamed Nazar, Nor Ilyani Ab Rahman, Norny Syafinaz Alias, Nor Elina Ahmad, Wan Rohaidah Rani, Nurul Sahida Cardosa, Mary Suma Ng, Kim Swan Ye, Felicia Loh |
| author_facet |
Zin, Che Suraya Mohamed Nazar, Nor Ilyani Ab Rahman, Norny Syafinaz Alias, Nor Elina Ahmad, Wan Rohaidah Rani, Nurul Sahida Cardosa, Mary Suma Ng, Kim Swan Ye, Felicia Loh |
| author_sort |
Zin, Che Suraya |
| title |
Trends and patterns of analgesic prescribing in Malaysian public hospitals from 2010 to 2016 : Tramadol predominately used |
| title_short |
Trends and patterns of analgesic prescribing in Malaysian public hospitals from 2010 to 2016 : Tramadol predominately used |
| title_full |
Trends and patterns of analgesic prescribing in Malaysian public hospitals from 2010 to 2016 : Tramadol predominately used |
| title_fullStr |
Trends and patterns of analgesic prescribing in Malaysian public hospitals from 2010 to 2016 : Tramadol predominately used |
| title_full_unstemmed |
Trends and patterns of analgesic prescribing in Malaysian public hospitals from 2010 to 2016 : Tramadol predominately used |
| title_sort |
trends and patterns of analgesic prescribing in malaysian public hospitals from 2010 to 2016 : tramadol predominately used |
| publisher |
Dove Press Ltd |
| publishDate |
2018 |
| url |
http://irep.iium.edu.my/66546/ http://irep.iium.edu.my/66546/ http://irep.iium.edu.my/66546/ http://irep.iium.edu.my/66546/1/Zin_tramadol_f_jpr-164774-trends-and-patterns-of-analgesic-prescribing-in-malaysian-pu-091918_44589.pdf http://irep.iium.edu.my/66546/8/66546_Trends%20and%20patterns%20of%20analgesic%20prescribing%20in%20Malaysian%20public%20hospitals%20from%202010%20to%202016_SCOPUS.pdf http://irep.iium.edu.my/66546/14/66546_Trends%20and%20patterns%20of%20analgesic%20prescribing%20in%20Malaysian%20public%20hospitals%20from%202010%20to%202016%20tramadol%20predominately%20used_WOS.pdf |
| first_indexed |
2023-09-18T21:34:30Z |
| last_indexed |
2023-09-18T21:34:30Z |
| _version_ |
1777412729951223808 |