Antioxidant and α‐glucosidase inhibitory activities and gas chromatography–mass spectrometry pro le of salak (salacca zalacca) fruit peel extracts

Background: This study was aimed to investigate antioxidant and α‑glucosidase inhibitory activity, with a proximate analysis of total phenolic and total flavonoid content with gas chromatography–mass spectrometry (GC‑MS) profiling of salak (Salacca zalacca) fruit peel extracts. Materials and Met...

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Main Authors:	Saleh, Mohammed S M, Siddiqui, Mohammad Jamshed Ahmad, Mat So'ad, Siti Zaiton, Murugesu, Suganya, Khatib, Alfi, Rahman, Md. Mokhlesur
Format:	Article
Language:	English English English
Published:	Wolters Kluwer ‐ Medknow 2018
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/66608/ http://irep.iium.edu.my/66608/ http://irep.iium.edu.my/66608/ http://irep.iium.edu.my/66608/19/66608_Antioxidant%20and%20%CE%B1%E2%80%90glucosidase%20inhibitory%20activities%20and%20gas_complete.pdf http://irep.iium.edu.my/66608/2/66608_Antioxidant%20and%20%CE%B1%E2%80%90glucosidase%20inhibitory_SCOPUS.pdf http://irep.iium.edu.my/66608/3/66608_Antioxidant%20and%20%CE%B1%E2%80%90glucosidase%20inhibitory_WOS.pdf

id	iium-66608
recordtype	eprints
spelling	iium-666082019-03-21T02:22:07Z http://irep.iium.edu.my/66608/ Antioxidant and α‐glucosidase inhibitory activities and gas chromatography–mass spectrometry pro le of salak (salacca zalacca) fruit peel extracts Saleh, Mohammed S M Siddiqui, Mohammad Jamshed Ahmad Mat So'ad, Siti Zaiton Murugesu, Suganya Khatib, Alfi Rahman, Md. Mokhlesur QD Chemistry Background: This study was aimed to investigate antioxidant and α‑glucosidase inhibitory activity, with a proximate analysis of total phenolic and total flavonoid content with gas chromatography–mass spectrometry (GC‑MS) profiling of salak (Salacca zalacca) fruit peel extracts. Materials and Methods: The peels extracts were prepared by maceration process at room temperature with different ratio of ethanol/water. Results: Phytochemical screening showed the presence of phenolic and flavonoid contents in all the extracts. About 100% ethanol extract shows the highest phenolic content (116.70 ± 0.764 μg/mL) while 60% ethanol extract has the lowest content 18.65 ± 1.155 μg/ml using gallic acid as a reference. 100% ethanol extract was observed to exhibit highest radical scavenging, ferric reducing antioxidant power (FRAP), and α‑glucosidaseinhibitory activities (IC50: 49.45 ± 3.87 μg/mL, 144.81 ± 3.72 μg AAE/g,IC50: 11.62 ± 0.67b μg/mL), respectively. Water extracts had the lowestFRAP, radical scavenging activity as well as α‑glucosidase activity. The phytochemical investigation on GC‑MS showed the presence of active compounds in salak fruit peel extracts. Conclusion: Salak fruit peels showed the highest antioxidant as well as α‑glucosidase inhibitory activities. Phytochemical analysis on GC‑MS confirms the presence of gallic acid, linoelaidic acid, palmitic acid, α‑tocopherol, and steric acid whichmay contribute to α‑glucosidase inhibitory activity. Wolters Kluwer ‐ Medknow 2018-10 Article PeerReviewed application/pdf en http://irep.iium.edu.my/66608/19/66608_Antioxidant%20and%20%CE%B1%E2%80%90glucosidase%20inhibitory%20activities%20and%20gas_complete.pdf application/pdf en http://irep.iium.edu.my/66608/2/66608_Antioxidant%20and%20%CE%B1%E2%80%90glucosidase%20inhibitory_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/66608/3/66608_Antioxidant%20and%20%CE%B1%E2%80%90glucosidase%20inhibitory_WOS.pdf Saleh, Mohammed S M and Siddiqui, Mohammad Jamshed Ahmad and Mat So'ad, Siti Zaiton and Murugesu, Suganya and Khatib, Alfi and Rahman, Md. Mokhlesur (2018) Antioxidant and α‐glucosidase inhibitory activities and gas chromatography–mass spectrometry pro le of salak (salacca zalacca) fruit peel extracts. Pharmacognosy Research, 10 (4 (Oct.-Dec.)). pp. 385-390. ISSN 0974-8490 http://www.phcogres.com/article.asp?issn=0974-8490;year=2018;volume=10;issue=4;spage=385;epage=390;aulast=Saleh;type=0 10.4103/pr.pr_7_18
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	QD Chemistry
spellingShingle	QD Chemistry Saleh, Mohammed S M Siddiqui, Mohammad Jamshed Ahmad Mat So'ad, Siti Zaiton Murugesu, Suganya Khatib, Alfi Rahman, Md. Mokhlesur Antioxidant and α‐glucosidase inhibitory activities and gas chromatography–mass spectrometry pro le of salak (salacca zalacca) fruit peel extracts
description	Background: This study was aimed to investigate antioxidant and α‑glucosidase inhibitory activity, with a proximate analysis of total phenolic and total flavonoid content with gas chromatography–mass spectrometry (GC‑MS) profiling of salak (Salacca zalacca) fruit peel extracts. Materials and Methods: The peels extracts were prepared by maceration process at room temperature with different ratio of ethanol/water. Results: Phytochemical screening showed the presence of phenolic and flavonoid contents in all the extracts. About 100% ethanol extract shows the highest phenolic content (116.70 ± 0.764 μg/mL) while 60% ethanol extract has the lowest content 18.65 ± 1.155 μg/ml using gallic acid as a reference. 100% ethanol extract was observed to exhibit highest radical scavenging, ferric reducing antioxidant power (FRAP), and α‑glucosidaseinhibitory activities (IC50: 49.45 ± 3.87 μg/mL, 144.81 ± 3.72 μg AAE/g,IC50: 11.62 ± 0.67b μg/mL), respectively. Water extracts had the lowestFRAP, radical scavenging activity as well as α‑glucosidase activity. The phytochemical investigation on GC‑MS showed the presence of active compounds in salak fruit peel extracts. Conclusion: Salak fruit peels showed the highest antioxidant as well as α‑glucosidase inhibitory activities. Phytochemical analysis on GC‑MS confirms the presence of gallic acid, linoelaidic acid, palmitic acid, α‑tocopherol, and steric acid whichmay contribute to α‑glucosidase inhibitory activity.
format	Article
author	Saleh, Mohammed S M Siddiqui, Mohammad Jamshed Ahmad Mat So'ad, Siti Zaiton Murugesu, Suganya Khatib, Alfi Rahman, Md. Mokhlesur
author_facet	Saleh, Mohammed S M Siddiqui, Mohammad Jamshed Ahmad Mat So'ad, Siti Zaiton Murugesu, Suganya Khatib, Alfi Rahman, Md. Mokhlesur
author_sort	Saleh, Mohammed S M
title	Antioxidant and α‐glucosidase inhibitory activities and gas chromatography–mass spectrometry pro le of salak (salacca zalacca) fruit peel extracts
title_short	Antioxidant and α‐glucosidase inhibitory activities and gas chromatography–mass spectrometry pro le of salak (salacca zalacca) fruit peel extracts
title_full	Antioxidant and α‐glucosidase inhibitory activities and gas chromatography–mass spectrometry pro le of salak (salacca zalacca) fruit peel extracts
title_fullStr	Antioxidant and α‐glucosidase inhibitory activities and gas chromatography–mass spectrometry pro le of salak (salacca zalacca) fruit peel extracts
title_full_unstemmed	Antioxidant and α‐glucosidase inhibitory activities and gas chromatography–mass spectrometry pro le of salak (salacca zalacca) fruit peel extracts
title_sort	antioxidant and α‐glucosidase inhibitory activities and gas chromatography–mass spectrometry pro le of salak (salacca zalacca) fruit peel extracts
publisher	Wolters Kluwer ‐ Medknow
publishDate	2018
url	http://irep.iium.edu.my/66608/ http://irep.iium.edu.my/66608/ http://irep.iium.edu.my/66608/ http://irep.iium.edu.my/66608/19/66608_Antioxidant%20and%20%CE%B1%E2%80%90glucosidase%20inhibitory%20activities%20and%20gas_complete.pdf http://irep.iium.edu.my/66608/2/66608_Antioxidant%20and%20%CE%B1%E2%80%90glucosidase%20inhibitory_SCOPUS.pdf http://irep.iium.edu.my/66608/3/66608_Antioxidant%20and%20%CE%B1%E2%80%90glucosidase%20inhibitory_WOS.pdf
first_indexed	2023-09-18T21:34:36Z
last_indexed	2023-09-18T21:34:36Z
_version_	1777412736966197248

Antioxidant and α‐glucosidase inhibitory activities and gas chromatography–mass spectrometry pro le of salak (salacca zalacca) fruit peel extracts

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