Neuroprotective properties of nigella sativa (L.) seeds extract in sprague dawley rats models

Neuroinflammation has been closely linked to neurodegeneration that leads to dysfunction of memory and learning where glial fibrillary acidic protein (GFAP) plays important role positively within hippocampus. In experimental neurodegeneration achieved by two-vessel occlusion (2VO) intervention, Ni...

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Main Authors:	Babar, Zahir Uddin, Azad, Abul Kalam, Wan Sulaiman, Wan Mohd Azizi, Uddin, Jalal, Labu, Zubair Khalid
Format:	Article
Language:	English English
Published:	University of Dhaka 2018
Subjects:	RC Internal medicine RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Online Access:	http://irep.iium.edu.my/66688/ http://irep.iium.edu.my/66688/ http://irep.iium.edu.my/66688/ http://irep.iium.edu.my/66688/1/66688_Neuroprotective%20Properties%20of%20Nigella%20sativa_article.pdf http://irep.iium.edu.my/66688/2/66688_Neuroprotective%20Properties%20of%20Nigella%20sativa_scopus.pdf

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recordtype	eprints
spelling	iium-666882018-10-08T07:20:34Z http://irep.iium.edu.my/66688/ Neuroprotective properties of nigella sativa (L.) seeds extract in sprague dawley rats models Babar, Zahir Uddin Azad, Abul Kalam Wan Sulaiman, Wan Mohd Azizi Uddin, Jalal Labu, Zubair Khalid RC Internal medicine RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Neuroinflammation has been closely linked to neurodegeneration that leads to dysfunction of memory and learning where glial fibrillary acidic protein (GFAP) plays important role positively within hippocampus. In experimental neurodegeneration achieved by two-vessel occlusion (2VO) intervention, Nigella sativa (L.) seeds extract (50 mg/kg/day orally) has shown to have anti-neuroinflammatory and antioxidant properties. The brain hippocampal tissues were humanely collected at the end of 10th treatment week and preserved in Allprotect™ reagent at –80°C. Total RNA was extracted and purified by phenol/chloroform method using kits and reverse transcribed into cDNA and relatively quantified as per ∆∆Cq. The NSSE treatment showed significantly (p<0.001) different relative GFAP mRNA expression in the treated group as compared to that of untreated 2VO whilst it was insignificantly (p>0.5) different to that of healthy control (HC). Prolonged or daily treatment with NSSE (Nigella sativa (L.) seeds extract) may provide moderate anti-neuroprotective activity within hippocampus. University of Dhaka 2018 Article PeerReviewed application/pdf en http://irep.iium.edu.my/66688/1/66688_Neuroprotective%20Properties%20of%20Nigella%20sativa_article.pdf application/pdf en http://irep.iium.edu.my/66688/2/66688_Neuroprotective%20Properties%20of%20Nigella%20sativa_scopus.pdf Babar, Zahir Uddin and Azad, Abul Kalam and Wan Sulaiman, Wan Mohd Azizi and Uddin, Jalal and Labu, Zubair Khalid (2018) Neuroprotective properties of nigella sativa (L.) seeds extract in sprague dawley rats models. Dhaka University Journal of Pharmaceutical Sciences, 17 (1). pp. 113-121. ISSN 1816-1820 E-ISSN 1816-1839 https://www.banglajol.info/index.php/JPharma/article/view/37127/25101 10.3329/dujps.v17i1.37127
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RC Internal medicine RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
spellingShingle	RC Internal medicine RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Babar, Zahir Uddin Azad, Abul Kalam Wan Sulaiman, Wan Mohd Azizi Uddin, Jalal Labu, Zubair Khalid Neuroprotective properties of nigella sativa (L.) seeds extract in sprague dawley rats models
description	Neuroinflammation has been closely linked to neurodegeneration that leads to dysfunction of memory and learning where glial fibrillary acidic protein (GFAP) plays important role positively within hippocampus. In experimental neurodegeneration achieved by two-vessel occlusion (2VO) intervention, Nigella sativa (L.) seeds extract (50 mg/kg/day orally) has shown to have anti-neuroinflammatory and antioxidant properties. The brain hippocampal tissues were humanely collected at the end of 10th treatment week and preserved in Allprotect™ reagent at –80°C. Total RNA was extracted and purified by phenol/chloroform method using kits and reverse transcribed into cDNA and relatively quantified as per ∆∆Cq. The NSSE treatment showed significantly (p<0.001) different relative GFAP mRNA expression in the treated group as compared to that of untreated 2VO whilst it was insignificantly (p>0.5) different to that of healthy control (HC). Prolonged or daily treatment with NSSE (Nigella sativa (L.) seeds extract) may provide moderate anti-neuroprotective activity within hippocampus.
format	Article
author	Babar, Zahir Uddin Azad, Abul Kalam Wan Sulaiman, Wan Mohd Azizi Uddin, Jalal Labu, Zubair Khalid
author_facet	Babar, Zahir Uddin Azad, Abul Kalam Wan Sulaiman, Wan Mohd Azizi Uddin, Jalal Labu, Zubair Khalid
author_sort	Babar, Zahir Uddin
title	Neuroprotective properties of nigella sativa (L.) seeds extract in sprague dawley rats models
title_short	Neuroprotective properties of nigella sativa (L.) seeds extract in sprague dawley rats models
title_full	Neuroprotective properties of nigella sativa (L.) seeds extract in sprague dawley rats models
title_fullStr	Neuroprotective properties of nigella sativa (L.) seeds extract in sprague dawley rats models
title_full_unstemmed	Neuroprotective properties of nigella sativa (L.) seeds extract in sprague dawley rats models
title_sort	neuroprotective properties of nigella sativa (l.) seeds extract in sprague dawley rats models
publisher	University of Dhaka
publishDate	2018
url	http://irep.iium.edu.my/66688/ http://irep.iium.edu.my/66688/ http://irep.iium.edu.my/66688/ http://irep.iium.edu.my/66688/1/66688_Neuroprotective%20Properties%20of%20Nigella%20sativa_article.pdf http://irep.iium.edu.my/66688/2/66688_Neuroprotective%20Properties%20of%20Nigella%20sativa_scopus.pdf
first_indexed	2023-09-18T21:34:42Z
last_indexed	2023-09-18T21:34:42Z
_version_	1777412743297499136

Neuroprotective properties of nigella sativa (L.) seeds extract in sprague dawley rats models

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