Chemical profile, total phenolic content, DPPH free radical scavenging and α-lucosidase inhibitory activities of cosmos caudatus kunth leaves
Herbs and medicinal plants are major sources of traditional or folk medicines for many countries of the world, including Malaysia. This study evaluated the bioactive potential of the leaf ethanolic extract and solvent fractions of Cosmos caudatus Kunth, in scavenging free radicals and inhibiting t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
UPM Press
2018
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/66759/ http://irep.iium.edu.my/66759/ http://irep.iium.edu.my/66759/7/66759%20Chemical%20Profile%2C%20Total%20Phenolic%20Content.pdf http://irep.iium.edu.my/66759/13/66759_Chemical%20profile%2C%20total%20phenolic%20content%2C%20DPPH%20free%20radical%20scavenging_SCOPUS.pdf |
| Summary: | Herbs and medicinal plants are major sources of traditional or folk medicines for many countries of the world, including Malaysia. This study evaluated the bioactive potential of
the leaf ethanolic extract and solvent fractions of Cosmos caudatus Kunth, in scavenging free radicals and inhibiting the enzyme α-glucosidase. In addition, their metabolite profiles were also characterized using liquid chromatography–mass spectrometry. The bioactivity
was found to be concentrated in the EtOAc and BuOH fractions which largely contained rutin, quercetin 3-O-galactoside, quercetin 3-O-glucoside, quercetin 3-O-xyloside, quercetin
3-O-arabinofuranoside, quercetin 3-O-rhamnoside, and quercetin 3-O-galactoside, as profiled by LC-MS/MS. It was further shown that the flavonoids glycosides contributed to the free radical scavenging and glucose lowering
effects of C. caudatus leaves. The results
indicated that the leaves of C. caudatus are a rich source of bioactive compounds and could be prospective materials for development of new anti-diabetic agents. |
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