Chemical profile, total phenolic content, DPPH free radical scavenging and α-lucosidase inhibitory activities of cosmos caudatus kunth leaves

Herbs and medicinal plants are major sources of traditional or folk medicines for many countries of the world, including Malaysia. This study evaluated the bioactive potential of the leaf ethanolic extract and solvent fractions of Cosmos caudatus Kunth, in scavenging free radicals and inhibiting t...

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Main Authors: Wan Ahmad, Wan Nadilah, Shaari, Khozirah, Khatib, Alfi, Abd hamid, Azizah, Hamid, Muhajir
Format: Article
Language:English
English
Published: UPM Press 2018
Subjects:
Online Access:http://irep.iium.edu.my/66759/
http://irep.iium.edu.my/66759/
http://irep.iium.edu.my/66759/7/66759%20Chemical%20Profile%2C%20Total%20Phenolic%20Content.pdf
http://irep.iium.edu.my/66759/13/66759_Chemical%20profile%2C%20total%20phenolic%20content%2C%20DPPH%20free%20radical%20scavenging_SCOPUS.pdf
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spelling iium-667592019-01-23T04:30:50Z http://irep.iium.edu.my/66759/ Chemical profile, total phenolic content, DPPH free radical scavenging and α-lucosidase inhibitory activities of cosmos caudatus kunth leaves Wan Ahmad, Wan Nadilah Shaari, Khozirah Khatib, Alfi Abd hamid, Azizah Hamid, Muhajir RS403 Materia Medica-Pharmaceutical Chemistry Herbs and medicinal plants are major sources of traditional or folk medicines for many countries of the world, including Malaysia. This study evaluated the bioactive potential of the leaf ethanolic extract and solvent fractions of Cosmos caudatus Kunth, in scavenging free radicals and inhibiting the enzyme α-glucosidase. In addition, their metabolite profiles were also characterized using liquid chromatography–mass spectrometry. The bioactivity was found to be concentrated in the EtOAc and BuOH fractions which largely contained rutin, quercetin 3-O-galactoside, quercetin 3-O-glucoside, quercetin 3-O-xyloside, quercetin 3-O-arabinofuranoside, quercetin 3-O-rhamnoside, and quercetin 3-O-galactoside, as profiled by LC-MS/MS. It was further shown that the flavonoids glycosides contributed to the free radical scavenging and glucose lowering effects of C. caudatus leaves. The results indicated that the leaves of C. caudatus are a rich source of bioactive compounds and could be prospective materials for development of new anti-diabetic agents. UPM Press 2018-08 Article PeerReviewed application/pdf en http://irep.iium.edu.my/66759/7/66759%20Chemical%20Profile%2C%20Total%20Phenolic%20Content.pdf application/pdf en http://irep.iium.edu.my/66759/13/66759_Chemical%20profile%2C%20total%20phenolic%20content%2C%20DPPH%20free%20radical%20scavenging_SCOPUS.pdf Wan Ahmad, Wan Nadilah and Shaari, Khozirah and Khatib, Alfi and Abd hamid, Azizah and Hamid, Muhajir (2018) Chemical profile, total phenolic content, DPPH free radical scavenging and α-lucosidase inhibitory activities of cosmos caudatus kunth leaves. Pertanika Journal of Tropical Agricultural Science, 41 (3). pp. 1367-1381. ISSN 1511-3701 E-ISSN 2231-8542 http://www.pertanika.upm.edu.my/Pertanika%20PAPERS/JTAS%20Vol.%2041%20(3)%20Aug.%202018/32%20JTAS%201327-2018.pdf
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
English
topic RS403 Materia Medica-Pharmaceutical Chemistry
spellingShingle RS403 Materia Medica-Pharmaceutical Chemistry
Wan Ahmad, Wan Nadilah
Shaari, Khozirah
Khatib, Alfi
Abd hamid, Azizah
Hamid, Muhajir
Chemical profile, total phenolic content, DPPH free radical scavenging and α-lucosidase inhibitory activities of cosmos caudatus kunth leaves
description Herbs and medicinal plants are major sources of traditional or folk medicines for many countries of the world, including Malaysia. This study evaluated the bioactive potential of the leaf ethanolic extract and solvent fractions of Cosmos caudatus Kunth, in scavenging free radicals and inhibiting the enzyme α-glucosidase. In addition, their metabolite profiles were also characterized using liquid chromatography–mass spectrometry. The bioactivity was found to be concentrated in the EtOAc and BuOH fractions which largely contained rutin, quercetin 3-O-galactoside, quercetin 3-O-glucoside, quercetin 3-O-xyloside, quercetin 3-O-arabinofuranoside, quercetin 3-O-rhamnoside, and quercetin 3-O-galactoside, as profiled by LC-MS/MS. It was further shown that the flavonoids glycosides contributed to the free radical scavenging and glucose lowering effects of C. caudatus leaves. The results indicated that the leaves of C. caudatus are a rich source of bioactive compounds and could be prospective materials for development of new anti-diabetic agents.
format Article
author Wan Ahmad, Wan Nadilah
Shaari, Khozirah
Khatib, Alfi
Abd hamid, Azizah
Hamid, Muhajir
author_facet Wan Ahmad, Wan Nadilah
Shaari, Khozirah
Khatib, Alfi
Abd hamid, Azizah
Hamid, Muhajir
author_sort Wan Ahmad, Wan Nadilah
title Chemical profile, total phenolic content, DPPH free radical scavenging and α-lucosidase inhibitory activities of cosmos caudatus kunth leaves
title_short Chemical profile, total phenolic content, DPPH free radical scavenging and α-lucosidase inhibitory activities of cosmos caudatus kunth leaves
title_full Chemical profile, total phenolic content, DPPH free radical scavenging and α-lucosidase inhibitory activities of cosmos caudatus kunth leaves
title_fullStr Chemical profile, total phenolic content, DPPH free radical scavenging and α-lucosidase inhibitory activities of cosmos caudatus kunth leaves
title_full_unstemmed Chemical profile, total phenolic content, DPPH free radical scavenging and α-lucosidase inhibitory activities of cosmos caudatus kunth leaves
title_sort chemical profile, total phenolic content, dpph free radical scavenging and α-lucosidase inhibitory activities of cosmos caudatus kunth leaves
publisher UPM Press
publishDate 2018
url http://irep.iium.edu.my/66759/
http://irep.iium.edu.my/66759/
http://irep.iium.edu.my/66759/7/66759%20Chemical%20Profile%2C%20Total%20Phenolic%20Content.pdf
http://irep.iium.edu.my/66759/13/66759_Chemical%20profile%2C%20total%20phenolic%20content%2C%20DPPH%20free%20radical%20scavenging_SCOPUS.pdf
first_indexed 2023-09-18T21:34:49Z
last_indexed 2023-09-18T21:34:49Z
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