Strontium ranelate reduces duration of consolidation phase in distraction osteogenesis: 2 case reports

Distraction osteogenesis a debilitating and time consuming procedure in orthopedics. The common indications for distraction osteogenesis are open fractures, non union and bone resection due to chronic osteomyelitis or large bone loss at initial time of trauma. It is often a limb salvage procedure...

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Main Authors:	Subramaniam, Kishan Rao, Mor Japar Khan, Ed Simor Khan, Zulkifly, Ahmad Hafiz, Sood, Ashwini
Format:	Article
Language:	English
Published:	Crimson Publishers 2018
Subjects:	RD701 Orthopedics
Online Access:	http://irep.iium.edu.my/66858/ http://irep.iium.edu.my/66858/ http://irep.iium.edu.my/66858/ http://irep.iium.edu.my/66858/1/2017%20Strontium%20Ranelate-%20case%20report.pdf

id	iium-66858
recordtype	eprints
spelling	iium-668582018-10-22T07:05:51Z http://irep.iium.edu.my/66858/ Strontium ranelate reduces duration of consolidation phase in distraction osteogenesis: 2 case reports Subramaniam, Kishan Rao Mor Japar Khan, Ed Simor Khan Zulkifly, Ahmad Hafiz Sood, Ashwini RD701 Orthopedics Distraction osteogenesis a debilitating and time consuming procedure in orthopedics. The common indications for distraction osteogenesis are open fractures, non union and bone resection due to chronic osteomyelitis or large bone loss at initial time of trauma. It is often a limb salvage procedure but also has a role in cosmetic lengthening in short statures. In distraction osteogenesis, there are 3 main phases; latent phase, distraction phase and consolidation phase. Often, patient has to be on external fixator (eg: ilizarov, LRS) for the entire duration of the distraction osteogenesis until clinical union is achieved (frame time). Prolonged external fixation is uncomfortable for the patient and is associated with many complications. Strontium ranelate is widely used in treatment of osteoporosis and to prevent fractures in elderly population. It has dual action and it promotes osteoblastic activity and inhibits osteoclastic activities in bone cells. From our cases, we have found that strontium ranelate given to patients at the end of distraction phase of distraction osteogenesis have significantly reduced the duration of consolidation phase, thus shortening the duration of the patients on external fixator (frame time). Strontium ranelate is a cost effective and non invasive alternative and can be used to reduce patients’ suffering, improve patients’ compliance and reduce the disability period. However, further evaluation of the safety profile of the drug needs to be taken into consideration. Crimson Publishers 2018 Article NonPeerReviewed application/pdf en http://irep.iium.edu.my/66858/1/2017%20Strontium%20Ranelate-%20case%20report.pdf Subramaniam, Kishan Rao and Mor Japar Khan, Ed Simor Khan and Zulkifly, Ahmad Hafiz and Sood, Ashwini (2018) Strontium ranelate reduces duration of consolidation phase in distraction osteogenesis: 2 case reports. Orthopedic Research Online Journal, 3 (5). pp. 1-5. ISSN 2576-8875 https://crimsonpublishers.com/oproj/pdf/OPROJ.000571.pdf 10.31031/OPROJ.2018.03.000571
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RD701 Orthopedics
spellingShingle	RD701 Orthopedics Subramaniam, Kishan Rao Mor Japar Khan, Ed Simor Khan Zulkifly, Ahmad Hafiz Sood, Ashwini Strontium ranelate reduces duration of consolidation phase in distraction osteogenesis: 2 case reports
description	Distraction osteogenesis a debilitating and time consuming procedure in orthopedics. The common indications for distraction osteogenesis are open fractures, non union and bone resection due to chronic osteomyelitis or large bone loss at initial time of trauma. It is often a limb salvage procedure but also has a role in cosmetic lengthening in short statures. In distraction osteogenesis, there are 3 main phases; latent phase, distraction phase and consolidation phase. Often, patient has to be on external fixator (eg: ilizarov, LRS) for the entire duration of the distraction osteogenesis until clinical union is achieved (frame time). Prolonged external fixation is uncomfortable for the patient and is associated with many complications. Strontium ranelate is widely used in treatment of osteoporosis and to prevent fractures in elderly population. It has dual action and it promotes osteoblastic activity and inhibits osteoclastic activities in bone cells. From our cases, we have found that strontium ranelate given to patients at the end of distraction phase of distraction osteogenesis have significantly reduced the duration of consolidation phase, thus shortening the duration of the patients on external fixator (frame time). Strontium ranelate is a cost effective and non invasive alternative and can be used to reduce patients’ suffering, improve patients’ compliance and reduce the disability period. However, further evaluation of the safety profile of the drug needs to be taken into consideration.
format	Article
author	Subramaniam, Kishan Rao Mor Japar Khan, Ed Simor Khan Zulkifly, Ahmad Hafiz Sood, Ashwini
author_facet	Subramaniam, Kishan Rao Mor Japar Khan, Ed Simor Khan Zulkifly, Ahmad Hafiz Sood, Ashwini
author_sort	Subramaniam, Kishan Rao
title	Strontium ranelate reduces duration of consolidation phase in distraction osteogenesis: 2 case reports
title_short	Strontium ranelate reduces duration of consolidation phase in distraction osteogenesis: 2 case reports
title_full	Strontium ranelate reduces duration of consolidation phase in distraction osteogenesis: 2 case reports
title_fullStr	Strontium ranelate reduces duration of consolidation phase in distraction osteogenesis: 2 case reports
title_full_unstemmed	Strontium ranelate reduces duration of consolidation phase in distraction osteogenesis: 2 case reports
title_sort	strontium ranelate reduces duration of consolidation phase in distraction osteogenesis: 2 case reports
publisher	Crimson Publishers
publishDate	2018
url	http://irep.iium.edu.my/66858/ http://irep.iium.edu.my/66858/ http://irep.iium.edu.my/66858/ http://irep.iium.edu.my/66858/1/2017%20Strontium%20Ranelate-%20case%20report.pdf
first_indexed	2023-09-18T21:34:56Z
last_indexed	2023-09-18T21:34:56Z
_version_	1777412757589590016

Strontium ranelate reduces duration of consolidation phase in distraction osteogenesis: 2 case reports

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