Extracapsular spread in oral squamous cell carcinoma and its association with GGH, CDKN3 and CBX7
PURPOSE OF STUDY: Extracapsular spread (ECS) in oral squamous cell carcinoma (OSCC) indicates tumour aggressiveness and is associated with a higher risk for tumour recurrence, loco-regional spread and distant metastasis. The identification of specific biomarkers that could predict ECS would gui...
| Main Authors: | , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
2018
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/67369/ http://irep.iium.edu.my/67369/ http://irep.iium.edu.my/67369/7/67369%20Extracapsular%20Spread%20in%20oral.pdf |
| Summary: | PURPOSE OF STUDY: Extracapsular spread (ECS) in
oral squamous cell carcinoma (OSCC) indicates tumour
aggressiveness and is associated with a higher risk for
tumour recurrence, loco-regional spread and distant
metastasis. The identification of specific biomarkers
that could predict ECS would guide the clinicians in the
management of OSCC patients. This study aimed to
determine the association between clinical and pathological
parameters of OSCC patients with ECS. We also sought to
investigate the expression of Gamma Glutamyl Hydrolase
(GGH), Cyclin Dependent Kinase Inhibitor 3 (CDKN3) and
Chromobox Homolog 7(CBX7) and their potential use as
biomarkers to predict ECS in OSCC.
MATERIALS AND METHODS: Association between
clinicopathological parameters and expression of these
markers with ECS status was analysed using chi-square test.
Immunohistochemical staining with anti-GGH, anti-CDKN3
and anti-CBX7 antibodies was performed on 35 OSCC
cases. RESULTS: The number of positive nodes and the
highest anatomical level of nodal involvement significantly correlated with ECS (p<0.05). Immunohistochemical
staining results indicated that high GGH expression was
significantly associated with ECS (p<0.05), while no
significant association was seen for CDKN3 and CBX7
expression with ECS. However, a trend towards significance
was observed with a high level of CDKN3 and low level of
CBX7 expression with ECS. CONCLUSIONS: The presence
of ECS is a predictor for the pathological involvement of
greater number of nodes from a higher anatomical level.
GGH offers potential as a prognostic biomarker in OSCC,
while the role of CDKN3 and CBX7 as prognostic markers
need to be validated in a larger sample. |
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