Phenolic-rich baccaurea angulata modulates inflammatory biomarkers of atherosclerosis

Purpose. Cardiovascular disease (CVD) is the leading and the most critical type of chronic disease. Atherosclerosis is the most common cause of CVD. Inflammation has been progressively acknowledged as a vital and central player in the pathophysiology of atherosclerosis. Baccaurea angulata is an un...

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Main Authors:	Ibrahim, Muhammad, Mikail, Maryam Abimbola, Ahmed, Idris Adewale, Abdul Ghani, Radiah
Format:	Article
Language:	English English English
Published:	Hindawi Publishing Corporation 2018
Subjects:	RB Pathology RM Therapeutics. Pharmacology
Online Access:	http://irep.iium.edu.my/67541/ http://irep.iium.edu.my/67541/ http://irep.iium.edu.my/67541/ http://irep.iium.edu.my/67541/7/67541%20Phenolic-Rich%20Baccaurea%20angulata.pdf http://irep.iium.edu.my/67541/13/67541%20Phenolic-Rich%20Baccaurea%20angulata_SCOPUS.pdf http://irep.iium.edu.my/67541/19/67541_Phenolic-rich%20baccaurea%20angulata%20modulates_WOS.pdf

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recordtype	eprints
spelling	iium-675412019-03-14T03:07:35Z http://irep.iium.edu.my/67541/ Phenolic-rich baccaurea angulata modulates inflammatory biomarkers of atherosclerosis Ibrahim, Muhammad Mikail, Maryam Abimbola Ahmed, Idris Adewale Abdul Ghani, Radiah RB Pathology RM Therapeutics. Pharmacology Purpose. Cardiovascular disease (CVD) is the leading and the most critical type of chronic disease. Atherosclerosis is the most common cause of CVD. Inflammation has been progressively acknowledged as a vital and central player in the pathophysiology of atherosclerosis. Baccaurea angulata is an underutilized fruit of the island of Borneo. It was obtained from Bau, Sarawak, Malaysia. In our previous studies, B. angulata did not only increase antioxidant enzyme activities, but also slowed the lipid peroxidation process in high-cholesterol-fed rabbits. It was hypothesized that B. angulata fruit would exert an anti-inflammatory effect. is study, therefore, aimed at evaluating and comparing the effects of three different B. angulata whole fruit (WF) juice doses on 11 serum inflammatory biomarkers of atherosclerosis. Methods. irty-five male New Zealand white rabbits were divided into seven groups (n � 5). Group CH was fed 1% cholesterol diet only, group C1 was fed 1% cholesterol diet and 0.5 ml/kg/day B. angulata WF juice, group C2 was fed 1% cholesterol diet and 1.0 ml/kg/day B. angulata WF juice, group C3 was fed 1% cholesterol diet and 1.5 ml/kg/day B. angulata WF juice, group N was fed standard pellet only, group N1 was fed standard pellet and 0.5 ml/kg/day B. angulata WF juice, and group N2 was fed standard pellet and 1.0 ml/kg/day B. angulata WF juice for 12 weeks. Results. e administration of the various juices reduced the concentrations of induced serum inflammatory biomarkers. Conclusion. is protective effect of B. angulata fruit against cardiovascular risk might be due to its polyphenol content. Hindawi Publishing Corporation 2018 Article PeerReviewed application/pdf en http://irep.iium.edu.my/67541/7/67541%20Phenolic-Rich%20Baccaurea%20angulata.pdf application/pdf en http://irep.iium.edu.my/67541/13/67541%20Phenolic-Rich%20Baccaurea%20angulata_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/67541/19/67541_Phenolic-rich%20baccaurea%20angulata%20modulates_WOS.pdf Ibrahim, Muhammad and Mikail, Maryam Abimbola and Ahmed, Idris Adewale and Abdul Ghani, Radiah (2018) Phenolic-rich baccaurea angulata modulates inflammatory biomarkers of atherosclerosis. Journal of Nutrition and Metabolism, 2018. pp. 1-8. ISSN 2090-0724 E-ISSN 2090-0732 https://www.hindawi.com/journals/jnme/2018/8406193/ 10.1155/2018/8406193
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RB Pathology RM Therapeutics. Pharmacology
spellingShingle	RB Pathology RM Therapeutics. Pharmacology Ibrahim, Muhammad Mikail, Maryam Abimbola Ahmed, Idris Adewale Abdul Ghani, Radiah Phenolic-rich baccaurea angulata modulates inflammatory biomarkers of atherosclerosis
description	Purpose. Cardiovascular disease (CVD) is the leading and the most critical type of chronic disease. Atherosclerosis is the most common cause of CVD. Inflammation has been progressively acknowledged as a vital and central player in the pathophysiology of atherosclerosis. Baccaurea angulata is an underutilized fruit of the island of Borneo. It was obtained from Bau, Sarawak, Malaysia. In our previous studies, B. angulata did not only increase antioxidant enzyme activities, but also slowed the lipid peroxidation process in high-cholesterol-fed rabbits. It was hypothesized that B. angulata fruit would exert an anti-inflammatory effect. is study, therefore, aimed at evaluating and comparing the effects of three different B. angulata whole fruit (WF) juice doses on 11 serum inflammatory biomarkers of atherosclerosis. Methods. irty-five male New Zealand white rabbits were divided into seven groups (n � 5). Group CH was fed 1% cholesterol diet only, group C1 was fed 1% cholesterol diet and 0.5 ml/kg/day B. angulata WF juice, group C2 was fed 1% cholesterol diet and 1.0 ml/kg/day B. angulata WF juice, group C3 was fed 1% cholesterol diet and 1.5 ml/kg/day B. angulata WF juice, group N was fed standard pellet only, group N1 was fed standard pellet and 0.5 ml/kg/day B. angulata WF juice, and group N2 was fed standard pellet and 1.0 ml/kg/day B. angulata WF juice for 12 weeks. Results. e administration of the various juices reduced the concentrations of induced serum inflammatory biomarkers. Conclusion. is protective effect of B. angulata fruit against cardiovascular risk might be due to its polyphenol content.
format	Article
author	Ibrahim, Muhammad Mikail, Maryam Abimbola Ahmed, Idris Adewale Abdul Ghani, Radiah
author_facet	Ibrahim, Muhammad Mikail, Maryam Abimbola Ahmed, Idris Adewale Abdul Ghani, Radiah
author_sort	Ibrahim, Muhammad
title	Phenolic-rich baccaurea angulata modulates inflammatory biomarkers of atherosclerosis
title_short	Phenolic-rich baccaurea angulata modulates inflammatory biomarkers of atherosclerosis
title_full	Phenolic-rich baccaurea angulata modulates inflammatory biomarkers of atherosclerosis
title_fullStr	Phenolic-rich baccaurea angulata modulates inflammatory biomarkers of atherosclerosis
title_full_unstemmed	Phenolic-rich baccaurea angulata modulates inflammatory biomarkers of atherosclerosis
title_sort	phenolic-rich baccaurea angulata modulates inflammatory biomarkers of atherosclerosis
publisher	Hindawi Publishing Corporation
publishDate	2018
url	http://irep.iium.edu.my/67541/ http://irep.iium.edu.my/67541/ http://irep.iium.edu.my/67541/ http://irep.iium.edu.my/67541/7/67541%20Phenolic-Rich%20Baccaurea%20angulata.pdf http://irep.iium.edu.my/67541/13/67541%20Phenolic-Rich%20Baccaurea%20angulata_SCOPUS.pdf http://irep.iium.edu.my/67541/19/67541_Phenolic-rich%20baccaurea%20angulata%20modulates_WOS.pdf
first_indexed	2023-09-18T21:35:52Z
last_indexed	2023-09-18T21:35:52Z
_version_	1777412816767025152

Phenolic-rich baccaurea angulata modulates inflammatory biomarkers of atherosclerosis

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