Preliminary study on the formulation of syariah compliant generic sustained release gliclazide tablet using xanthan gum
Gliclazide (1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea) is a second-generation sulfonylurea which is orally administered in the treatment of non-insulin-dependent diabetes mellitus in adults. Sustain release drugs help to improve...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia
2018
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/67661/ http://irep.iium.edu.my/67661/ http://irep.iium.edu.my/67661/1/Preliminary%20Study%20on%20the%20Formulation%20of%20Syariah%20-Dr.%20Helal.pdf |
| Summary: | Gliclazide (1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea) is a
second-generation sulfonylurea which is orally administered in the treatment of non-insulin-dependent
diabetes mellitus in adults. Sustain release drugs help to improve drugs bioavailability by controlling the
time of drug release or prolonging it. We are reporting the preliminary formulation of sustain release
gliclazide tablets with careful choice of all the ingredients and processes related to syariah compliance
manufacturing of pharmaceutical products. In this work, xanthan gum, a natural gum was used to achieve
the sustain release criteria. The tablets were produced by wet granulation and semi-automatic tableting
process. Tablet characterisation was done following the British Pharmacopoeia (BP) criteria. We expect that
the outcome of our study will result in a suitable formulation that could be useful for the formulation of
such product that will be helpful for the Muslim patient especially during the fasting month. |
|---|