Preliminary study on the formulation of syariah compliant generic sustained release gliclazide tablet using xanthan gum

Gliclazide (1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea) is a second-generation sulfonylurea which is orally administered in the treatment of non-insulin-dependent diabetes mellitus in adults. Sustain release drugs help to improve...

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Main Authors:	Mat Zin, Nik Mohamad Lukman, Abd Mubin, Anis Syazwani, Mohd Nawi, Mohamed Sufian, Helaluddin, Abul Bashar Mohammed, Kasmuri, Abdul Razak, Mandal, Uttam Kumar Umar
Format:	Article
Language:	English
Published:	Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia 2018
Subjects:	QD Chemistry RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry
Online Access:	http://irep.iium.edu.my/67661/ http://irep.iium.edu.my/67661/ http://irep.iium.edu.my/67661/1/Preliminary%20Study%20on%20the%20Formulation%20of%20Syariah%20-Dr.%20Helal.pdf

id	iium-67661
recordtype	eprints
spelling	iium-676612018-11-28T03:42:36Z http://irep.iium.edu.my/67661/ Preliminary study on the formulation of syariah compliant generic sustained release gliclazide tablet using xanthan gum Mat Zin, Nik Mohamad Lukman Abd Mubin, Anis Syazwani Mohd Nawi, Mohamed Sufian Helaluddin, Abul Bashar Mohammed Kasmuri, Abdul Razak Mandal, Uttam Kumar Umar QD Chemistry RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry Gliclazide (1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea) is a second-generation sulfonylurea which is orally administered in the treatment of non-insulin-dependent diabetes mellitus in adults. Sustain release drugs help to improve drugs bioavailability by controlling the time of drug release or prolonging it. We are reporting the preliminary formulation of sustain release gliclazide tablets with careful choice of all the ingredients and processes related to syariah compliance manufacturing of pharmaceutical products. In this work, xanthan gum, a natural gum was used to achieve the sustain release criteria. The tablets were produced by wet granulation and semi-automatic tableting process. Tablet characterisation was done following the British Pharmacopoeia (BP) criteria. We expect that the outcome of our study will result in a suitable formulation that could be useful for the formulation of such product that will be helpful for the Muslim patient especially during the fasting month. Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia 2018-10-18 Article PeerReviewed application/pdf en http://irep.iium.edu.my/67661/1/Preliminary%20Study%20on%20the%20Formulation%20of%20Syariah%20-Dr.%20Helal.pdf Mat Zin, Nik Mohamad Lukman and Abd Mubin, Anis Syazwani and Mohd Nawi, Mohamed Sufian and Helaluddin, Abul Bashar Mohammed and Kasmuri, Abdul Razak and Mandal, Uttam Kumar Umar (2018) Preliminary study on the formulation of syariah compliant generic sustained release gliclazide tablet using xanthan gum. International Medical journal Malaysia (IMJM), 17 (Special Issue 2). pp. 1-4. ISSN 1823-4631 http://iiumedic.net/imjm/v1/download/volume_17_special_issue_2/Pages-from-2WCII-SI2-001.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QD Chemistry RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry
spellingShingle	QD Chemistry RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry Mat Zin, Nik Mohamad Lukman Abd Mubin, Anis Syazwani Mohd Nawi, Mohamed Sufian Helaluddin, Abul Bashar Mohammed Kasmuri, Abdul Razak Mandal, Uttam Kumar Umar Preliminary study on the formulation of syariah compliant generic sustained release gliclazide tablet using xanthan gum
description	Gliclazide (1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea) is a second-generation sulfonylurea which is orally administered in the treatment of non-insulin-dependent diabetes mellitus in adults. Sustain release drugs help to improve drugs bioavailability by controlling the time of drug release or prolonging it. We are reporting the preliminary formulation of sustain release gliclazide tablets with careful choice of all the ingredients and processes related to syariah compliance manufacturing of pharmaceutical products. In this work, xanthan gum, a natural gum was used to achieve the sustain release criteria. The tablets were produced by wet granulation and semi-automatic tableting process. Tablet characterisation was done following the British Pharmacopoeia (BP) criteria. We expect that the outcome of our study will result in a suitable formulation that could be useful for the formulation of such product that will be helpful for the Muslim patient especially during the fasting month.
format	Article
author	Mat Zin, Nik Mohamad Lukman Abd Mubin, Anis Syazwani Mohd Nawi, Mohamed Sufian Helaluddin, Abul Bashar Mohammed Kasmuri, Abdul Razak Mandal, Uttam Kumar Umar
author_facet	Mat Zin, Nik Mohamad Lukman Abd Mubin, Anis Syazwani Mohd Nawi, Mohamed Sufian Helaluddin, Abul Bashar Mohammed Kasmuri, Abdul Razak Mandal, Uttam Kumar Umar
author_sort	Mat Zin, Nik Mohamad Lukman
title	Preliminary study on the formulation of syariah compliant generic sustained release gliclazide tablet using xanthan gum
title_short	Preliminary study on the formulation of syariah compliant generic sustained release gliclazide tablet using xanthan gum
title_full	Preliminary study on the formulation of syariah compliant generic sustained release gliclazide tablet using xanthan gum
title_fullStr	Preliminary study on the formulation of syariah compliant generic sustained release gliclazide tablet using xanthan gum
title_full_unstemmed	Preliminary study on the formulation of syariah compliant generic sustained release gliclazide tablet using xanthan gum
title_sort	preliminary study on the formulation of syariah compliant generic sustained release gliclazide tablet using xanthan gum
publisher	Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia
publishDate	2018
url	http://irep.iium.edu.my/67661/ http://irep.iium.edu.my/67661/ http://irep.iium.edu.my/67661/1/Preliminary%20Study%20on%20the%20Formulation%20of%20Syariah%20-Dr.%20Helal.pdf
first_indexed	2023-09-18T21:36:02Z
last_indexed	2023-09-18T21:36:02Z
_version_	1777412827126956032

Preliminary study on the formulation of syariah compliant generic sustained release gliclazide tablet using xanthan gum

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