Isolation and characterization of novel antibacterial compound from an untapped plant, Stereospermum fimbriatum
Stereospermum fimbriatum or locally known as “ Chicha ” is traditionally used for itchy skin, earache, stomachache and postpartum treatments. This study was designed to evaluate the antimicrobial potential of S. fimbriatum ’ s stem bark against 11 pathogens and isolate its bioactive compound. Succes...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Taylors & Francis
2020
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/68100/ http://irep.iium.edu.my/68100/ http://irep.iium.edu.my/68100/ http://irep.iium.edu.my/68100/8/68100_Isolation%20and%20characterization%20of%20novel%20antibacterial%20compound_SCOPUS%20inpress.pdf http://irep.iium.edu.my/68100/19/Isolation%20and%20characterization%20of%20novel%20antibacterial%20compound%20from%20an%20untapped%20plant%20Stereospermum%20fimbriatum.pdf |
| Summary: | Stereospermum fimbriatum or locally known as “ Chicha ” is traditionally used for itchy skin, earache, stomachache and postpartum treatments. This study was designed to evaluate the antimicrobial potential of S. fimbriatum ’ s stem bark against 11 pathogens and isolate its bioactive compound. Successive soxhlet extraction was conducted using n-hexane, dichloromethane DCM) and methanol. Disc diffusion, minimum inhibitory and bactericidal concentration (MIC & MBC) assays were done to examine the antimicrobial activity. Bioassay-guided isolation was conducted on S. fimbriatum ’ s extract. The DCM extract of stem bark(DS) was the most potent extract followed by n-hexane extract of the stem bark (NS). A novel compound was isolated and coded as C1 which demonstrated potent antibacterial effects with the MIC values as low as 3.13 m g/mL to 6.25 m g/mL, against S. epidermidis,MRSA and S. aureus. Thus, S. fimbriatum could be a potential source of antimicrobial agents for the treatment of skin infections,specifically, MRSA. |
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