Isolation and characterization of novel antibacterial compound from an untapped plant, Stereospermum fimbriatum

Stereospermum fimbriatum or locally known as “ Chicha ” is traditionally used for itchy skin, earache, stomachache and postpartum treatments. This study was designed to evaluate the antimicrobial potential of S. fimbriatum ’ s stem bark against 11 pathogens and isolate its bioactive compound. Succes...

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Main Authors:	Awang, Anis Fadhlina Izyani, Ahmed, Qamar Uddin, Ali Shah, Syed Adnan, Md. Jaffri, Juliana, Ghafoor, Kashif, Helaluddin, Abul Bashar Mohammed, Ferdosh, Sahena, Sarker, Md. Zaidul Islam
Format:	Article
Language:	English English
Published:	Taylors & Francis 2020
Subjects:	QD Chemistry RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry
Online Access:	http://irep.iium.edu.my/68100/ http://irep.iium.edu.my/68100/ http://irep.iium.edu.my/68100/ http://irep.iium.edu.my/68100/8/68100_Isolation%20and%20characterization%20of%20novel%20antibacterial%20compound_SCOPUS%20inpress.pdf http://irep.iium.edu.my/68100/19/Isolation%20and%20characterization%20of%20novel%20antibacterial%20compound%20from%20an%20untapped%20plant%20Stereospermum%20fimbriatum.pdf

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recordtype	eprints
spelling	iium-681002020-03-03T06:26:02Z http://irep.iium.edu.my/68100/ Isolation and characterization of novel antibacterial compound from an untapped plant, Stereospermum fimbriatum Awang, Anis Fadhlina Izyani Ahmed, Qamar Uddin Ali Shah, Syed Adnan Md. Jaffri, Juliana Ghafoor, Kashif Helaluddin, Abul Bashar Mohammed Ferdosh, Sahena Sarker, Md. Zaidul Islam QD Chemistry RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry Stereospermum fimbriatum or locally known as “ Chicha ” is traditionally used for itchy skin, earache, stomachache and postpartum treatments. This study was designed to evaluate the antimicrobial potential of S. fimbriatum ’ s stem bark against 11 pathogens and isolate its bioactive compound. Successive soxhlet extraction was conducted using n-hexane, dichloromethane DCM) and methanol. Disc diffusion, minimum inhibitory and bactericidal concentration (MIC & MBC) assays were done to examine the antimicrobial activity. Bioassay-guided isolation was conducted on S. fimbriatum ’ s extract. The DCM extract of stem bark(DS) was the most potent extract followed by n-hexane extract of the stem bark (NS). A novel compound was isolated and coded as C1 which demonstrated potent antibacterial effects with the MIC values as low as 3.13 m g/mL to 6.25 m g/mL, against S. epidermidis,MRSA and S. aureus. Thus, S. fimbriatum could be a potential source of antimicrobial agents for the treatment of skin infections,specifically, MRSA. Taylors & Francis 2020-02-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/68100/8/68100_Isolation%20and%20characterization%20of%20novel%20antibacterial%20compound_SCOPUS%20inpress.pdf application/pdf en http://irep.iium.edu.my/68100/19/Isolation%20and%20characterization%20of%20novel%20antibacterial%20compound%20from%20an%20untapped%20plant%20Stereospermum%20fimbriatum.pdf Awang, Anis Fadhlina Izyani and Ahmed, Qamar Uddin and Ali Shah, Syed Adnan and Md. Jaffri, Juliana and Ghafoor, Kashif and Helaluddin, Abul Bashar Mohammed and Ferdosh, Sahena and Sarker, Md. Zaidul Islam (2020) Isolation and characterization of novel antibacterial compound from an untapped plant, Stereospermum fimbriatum. Natural Product Research, 34 (5). pp. 629-637. ISSN 1478-6419 E-ISSN 1478-6427 https://www.tandfonline.com/doi/abs/10.1080/14786419.2018.1494170?journalCode=gnpl20 10.1080/14786419.2018.1494170
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QD Chemistry RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry
spellingShingle	QD Chemistry RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry Awang, Anis Fadhlina Izyani Ahmed, Qamar Uddin Ali Shah, Syed Adnan Md. Jaffri, Juliana Ghafoor, Kashif Helaluddin, Abul Bashar Mohammed Ferdosh, Sahena Sarker, Md. Zaidul Islam Isolation and characterization of novel antibacterial compound from an untapped plant, Stereospermum fimbriatum
description	Stereospermum fimbriatum or locally known as “ Chicha ” is traditionally used for itchy skin, earache, stomachache and postpartum treatments. This study was designed to evaluate the antimicrobial potential of S. fimbriatum ’ s stem bark against 11 pathogens and isolate its bioactive compound. Successive soxhlet extraction was conducted using n-hexane, dichloromethane DCM) and methanol. Disc diffusion, minimum inhibitory and bactericidal concentration (MIC & MBC) assays were done to examine the antimicrobial activity. Bioassay-guided isolation was conducted on S. fimbriatum ’ s extract. The DCM extract of stem bark(DS) was the most potent extract followed by n-hexane extract of the stem bark (NS). A novel compound was isolated and coded as C1 which demonstrated potent antibacterial effects with the MIC values as low as 3.13 m g/mL to 6.25 m g/mL, against S. epidermidis,MRSA and S. aureus. Thus, S. fimbriatum could be a potential source of antimicrobial agents for the treatment of skin infections,specifically, MRSA.
format	Article
author	Awang, Anis Fadhlina Izyani Ahmed, Qamar Uddin Ali Shah, Syed Adnan Md. Jaffri, Juliana Ghafoor, Kashif Helaluddin, Abul Bashar Mohammed Ferdosh, Sahena Sarker, Md. Zaidul Islam
author_facet	Awang, Anis Fadhlina Izyani Ahmed, Qamar Uddin Ali Shah, Syed Adnan Md. Jaffri, Juliana Ghafoor, Kashif Helaluddin, Abul Bashar Mohammed Ferdosh, Sahena Sarker, Md. Zaidul Islam
author_sort	Awang, Anis Fadhlina Izyani
title	Isolation and characterization of novel antibacterial compound from an untapped plant, Stereospermum fimbriatum
title_short	Isolation and characterization of novel antibacterial compound from an untapped plant, Stereospermum fimbriatum
title_full	Isolation and characterization of novel antibacterial compound from an untapped plant, Stereospermum fimbriatum
title_fullStr	Isolation and characterization of novel antibacterial compound from an untapped plant, Stereospermum fimbriatum
title_full_unstemmed	Isolation and characterization of novel antibacterial compound from an untapped plant, Stereospermum fimbriatum
title_sort	isolation and characterization of novel antibacterial compound from an untapped plant, stereospermum fimbriatum
publisher	Taylors & Francis
publishDate	2020
url	http://irep.iium.edu.my/68100/ http://irep.iium.edu.my/68100/ http://irep.iium.edu.my/68100/ http://irep.iium.edu.my/68100/8/68100_Isolation%20and%20characterization%20of%20novel%20antibacterial%20compound_SCOPUS%20inpress.pdf http://irep.iium.edu.my/68100/19/Isolation%20and%20characterization%20of%20novel%20antibacterial%20compound%20from%20an%20untapped%20plant%20Stereospermum%20fimbriatum.pdf
first_indexed	2023-09-18T21:36:39Z
last_indexed	2023-09-18T21:36:39Z
_version_	1777412865691484160

Isolation and characterization of novel antibacterial compound from an untapped plant, Stereospermum fimbriatum

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