Acute kidney injury in Malaysian intensive care setting: incidences, risk factors and outcome

Introduction: Acute Kidney Injury (AKI) is common in the intensive care unit (ICU) with high risk of morbidity and mortality. The high incidence of AKI in our population may be attributed to sepsis. We investigated the incidence, risk factors and outcome of AKI in four tertiary Malaysian ICUs. We al...

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Main Authors:	Md Ralib, Azrina, Nanyan, Suhaila, Ramly, Nur fariza, Mat Nor, Mohd Basri
Format:	Article
Language:	English English English
Published:	Wolters Kluwer Medknow Publications 2018
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/68309/ http://irep.iium.edu.my/68309/ http://irep.iium.edu.my/68309/ http://irep.iium.edu.my/68309/1/ijccm_2018_22_12_831_247743.pdf http://irep.iium.edu.my/68309/7/68309_Acute%20kidney%20injury%20in%20Malaysian%20intensive_scopus.pdf http://irep.iium.edu.my/68309/13/68309%20Acute%20Kidney%20Injury%20in%20Malaysian%20%20WOS.pdf

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spelling	iium-683092019-01-27T06:57:13Z http://irep.iium.edu.my/68309/ Acute kidney injury in Malaysian intensive care setting: incidences, risk factors and outcome Md Ralib, Azrina Nanyan, Suhaila Ramly, Nur fariza Mat Nor, Mohd Basri R Medicine (General) Introduction: Acute Kidney Injury (AKI) is common in the intensive care unit (ICU) with high risk of morbidity and mortality. The high incidence of AKI in our population may be attributed to sepsis. We investigated the incidence, risk factors and outcome of AKI in four tertiary Malaysian ICUs. We also evaluated its association with sepsis. Materials and Methods: This retrospective cohort study extracted de-identified data from the Malaysian Registry of Intensive Care in four Malaysian tertiary ICUs between January 2010 and December 2014. The study was registered under the NMRR and approved by the ethics committee. AKI was defined as twice the baseline creatinine or urine output < 0.5 ml/kg/h for 12 hours. Results: Of 26,663 patients, 24.2% had AKI within 24 hours of admission. Patients with AKI were older and had higher severity of illness compared to those without AKI. AKI patients had longer duration of mechanical ventilation, length of ICU and hospital stay. Age, SAPS II Score, and the presence of sepsis and preexisting hypertension, chronic cardiovascular disease independently associated with AKI. 32.3% had sepsis. Patients with both AKI and sepsis had highest risk of mortality (RR 3.43 (3.34 to 3.53)). Conclusions: AKI is common in our ICU, with higher morbidity and mortality. Independent risk factors of AKI include age, severity of illness, sepsis and preexisting hypertension, chronic cardiovascular disease. AKI independently contributes to mortality. The presence of AKI and sepsis increased the risk of mortality by three times. Wolters Kluwer Medknow Publications 2018-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/68309/1/ijccm_2018_22_12_831_247743.pdf application/pdf en http://irep.iium.edu.my/68309/7/68309_Acute%20kidney%20injury%20in%20Malaysian%20intensive_scopus.pdf application/pdf en http://irep.iium.edu.my/68309/13/68309%20Acute%20Kidney%20Injury%20in%20Malaysian%20%20WOS.pdf Md Ralib, Azrina and Nanyan, Suhaila and Ramly, Nur fariza and Mat Nor, Mohd Basri (2018) Acute kidney injury in Malaysian intensive care setting: incidences, risk factors and outcome. Indian Journal of Critical Care Medicine, 22 (12). pp. 831-835. ISSN 0972-5229 E-ISSN 1998-359X http://www.ijccm.org 10.4103/ijccm.IJCCM_193_18
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Md Ralib, Azrina Nanyan, Suhaila Ramly, Nur fariza Mat Nor, Mohd Basri Acute kidney injury in Malaysian intensive care setting: incidences, risk factors and outcome
description	Introduction: Acute Kidney Injury (AKI) is common in the intensive care unit (ICU) with high risk of morbidity and mortality. The high incidence of AKI in our population may be attributed to sepsis. We investigated the incidence, risk factors and outcome of AKI in four tertiary Malaysian ICUs. We also evaluated its association with sepsis. Materials and Methods: This retrospective cohort study extracted de-identified data from the Malaysian Registry of Intensive Care in four Malaysian tertiary ICUs between January 2010 and December 2014. The study was registered under the NMRR and approved by the ethics committee. AKI was defined as twice the baseline creatinine or urine output < 0.5 ml/kg/h for 12 hours. Results: Of 26,663 patients, 24.2% had AKI within 24 hours of admission. Patients with AKI were older and had higher severity of illness compared to those without AKI. AKI patients had longer duration of mechanical ventilation, length of ICU and hospital stay. Age, SAPS II Score, and the presence of sepsis and preexisting hypertension, chronic cardiovascular disease independently associated with AKI. 32.3% had sepsis. Patients with both AKI and sepsis had highest risk of mortality (RR 3.43 (3.34 to 3.53)). Conclusions: AKI is common in our ICU, with higher morbidity and mortality. Independent risk factors of AKI include age, severity of illness, sepsis and preexisting hypertension, chronic cardiovascular disease. AKI independently contributes to mortality. The presence of AKI and sepsis increased the risk of mortality by three times.
format	Article
author	Md Ralib, Azrina Nanyan, Suhaila Ramly, Nur fariza Mat Nor, Mohd Basri
author_facet	Md Ralib, Azrina Nanyan, Suhaila Ramly, Nur fariza Mat Nor, Mohd Basri
author_sort	Md Ralib, Azrina
title	Acute kidney injury in Malaysian intensive care setting: incidences, risk factors and outcome
title_short	Acute kidney injury in Malaysian intensive care setting: incidences, risk factors and outcome
title_full	Acute kidney injury in Malaysian intensive care setting: incidences, risk factors and outcome
title_fullStr	Acute kidney injury in Malaysian intensive care setting: incidences, risk factors and outcome
title_full_unstemmed	Acute kidney injury in Malaysian intensive care setting: incidences, risk factors and outcome
title_sort	acute kidney injury in malaysian intensive care setting: incidences, risk factors and outcome
publisher	Wolters Kluwer Medknow Publications
publishDate	2018
url	http://irep.iium.edu.my/68309/ http://irep.iium.edu.my/68309/ http://irep.iium.edu.my/68309/ http://irep.iium.edu.my/68309/1/ijccm_2018_22_12_831_247743.pdf http://irep.iium.edu.my/68309/7/68309_Acute%20kidney%20injury%20in%20Malaysian%20intensive_scopus.pdf http://irep.iium.edu.my/68309/13/68309%20Acute%20Kidney%20Injury%20in%20Malaysian%20%20WOS.pdf
first_indexed	2023-09-18T21:36:56Z
last_indexed	2023-09-18T21:36:56Z
_version_	1777412883754254336

Acute kidney injury in Malaysian intensive care setting: incidences, risk factors and outcome

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