Direct compressed tablet with melt dispersed drug particle without binder

Objective: To prepare ibuprofen tablet without binder by direct compression method. Methodology: Differential scanning calorimetry (DSC), attenuated total reflectance (ATR) and high performance liquid chromatography (HPLC)analysis were done to investigate ibuprofen stability during melting and so...

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Main Authors:	Ruzaidi, Ahmad Fahmi, Chatterjee, Bappaditya
Format:	Conference or Workshop Item
Language:	English English English
Published:	2017
Subjects:	RS192 Materia Medica-Pharmaceutical Technology
Online Access:	http://irep.iium.edu.my/68353/ http://irep.iium.edu.my/68353/1/MSSP%202017.pdf http://irep.iium.edu.my/68353/13/353%20MSPP%20prog%20book.pdf http://irep.iium.edu.my/68353/14/353%20PPT_BAPPA.pdf

id	iium-68353
recordtype	eprints
spelling	iium-683532018-12-10T07:09:49Z http://irep.iium.edu.my/68353/ Direct compressed tablet with melt dispersed drug particle without binder Ruzaidi, Ahmad Fahmi Chatterjee, Bappaditya RS192 Materia Medica-Pharmaceutical Technology Objective: To prepare ibuprofen tablet without binder by direct compression method. Methodology: Differential scanning calorimetry (DSC), attenuated total reflectance (ATR) and high performance liquid chromatography (HPLC)analysis were done to investigate ibuprofen stability during melting and solidification process as well as compatibility with microcrystalline cellulose (MCC). Ibuprofen was melted at 85 ºC and MCC was dispersed (Ibuprofen: MCC, 1.7: 1 w/w) in molten drug with constant stirring. The dispersion was solidified in an ice bath immediately and then pulverized followed by sieving through 600-micron sieve. The derived powder was tested for flow property and compressibility and compressed into tablet without adding any binder. The prepared tablets were evaluated for hardness, friability, disintegration and in vitro dissolution. Results: No differences in melting peak, enthalpy, functional groups, and chromatographic retention time were observed between ibuprofen and solidified molten ibuprofen. These results indicate heat stability of ibuprofen within the melting range. Compatibility between drug and MCC was also established. The melt dispersed drug powder showed higher bulk density (0.478 g/mL) and Carr index (12.545) compared to physical mixture (ibuprofenMCC). The compressed tablets showed acceptable hardness and friability (less than 1%) as well as acceptable disintegration time (< 30 min). The in vitro dissolution studies showed over 80 % drug release within 30 min. Partial conversion to amorphous nature as well as deformation of crystals by melting and re-solidifying are the reasons of sufficient hardness of the prepared tablet without using binder. Conclusion: Melt dispersed drug particle can be compressed into tablets without binder which will definitely reduce number of inactive ingredients in a tablet and time/cost of preparation. Improved flow property of the drug particles will help to enhance drug loading without granulation. Low melting point and heat stability of the drug at the melting range are desired for adopting such technique. 2017-08-18 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/68353/1/MSSP%202017.pdf application/pdf en http://irep.iium.edu.my/68353/13/353%20MSPP%20prog%20book.pdf application/pdf en http://irep.iium.edu.my/68353/14/353%20PPT_BAPPA.pdf Ruzaidi, Ahmad Fahmi and Chatterjee, Bappaditya (2017) Direct compressed tablet with melt dispersed drug particle without binder. In: 31st Scientific Meeting Malaysian Society of Pharmacology & Physiology 2017 (MSPP 2017), 18th-19th August, 2017, School of Dental Sciences, Health Campus, Universiti Sains Malaysia, Kota Bharu, Kelantan.. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RS192 Materia Medica-Pharmaceutical Technology
spellingShingle	RS192 Materia Medica-Pharmaceutical Technology Ruzaidi, Ahmad Fahmi Chatterjee, Bappaditya Direct compressed tablet with melt dispersed drug particle without binder
description	Objective: To prepare ibuprofen tablet without binder by direct compression method. Methodology: Differential scanning calorimetry (DSC), attenuated total reflectance (ATR) and high performance liquid chromatography (HPLC)analysis were done to investigate ibuprofen stability during melting and solidification process as well as compatibility with microcrystalline cellulose (MCC). Ibuprofen was melted at 85 ºC and MCC was dispersed (Ibuprofen: MCC, 1.7: 1 w/w) in molten drug with constant stirring. The dispersion was solidified in an ice bath immediately and then pulverized followed by sieving through 600-micron sieve. The derived powder was tested for flow property and compressibility and compressed into tablet without adding any binder. The prepared tablets were evaluated for hardness, friability, disintegration and in vitro dissolution. Results: No differences in melting peak, enthalpy, functional groups, and chromatographic retention time were observed between ibuprofen and solidified molten ibuprofen. These results indicate heat stability of ibuprofen within the melting range. Compatibility between drug and MCC was also established. The melt dispersed drug powder showed higher bulk density (0.478 g/mL) and Carr index (12.545) compared to physical mixture (ibuprofenMCC). The compressed tablets showed acceptable hardness and friability (less than 1%) as well as acceptable disintegration time (< 30 min). The in vitro dissolution studies showed over 80 % drug release within 30 min. Partial conversion to amorphous nature as well as deformation of crystals by melting and re-solidifying are the reasons of sufficient hardness of the prepared tablet without using binder. Conclusion: Melt dispersed drug particle can be compressed into tablets without binder which will definitely reduce number of inactive ingredients in a tablet and time/cost of preparation. Improved flow property of the drug particles will help to enhance drug loading without granulation. Low melting point and heat stability of the drug at the melting range are desired for adopting such technique.
format	Conference or Workshop Item
author	Ruzaidi, Ahmad Fahmi Chatterjee, Bappaditya
author_facet	Ruzaidi, Ahmad Fahmi Chatterjee, Bappaditya
author_sort	Ruzaidi, Ahmad Fahmi
title	Direct compressed tablet with melt dispersed drug particle without binder
title_short	Direct compressed tablet with melt dispersed drug particle without binder
title_full	Direct compressed tablet with melt dispersed drug particle without binder
title_fullStr	Direct compressed tablet with melt dispersed drug particle without binder
title_full_unstemmed	Direct compressed tablet with melt dispersed drug particle without binder
title_sort	direct compressed tablet with melt dispersed drug particle without binder
publishDate	2017
url	http://irep.iium.edu.my/68353/ http://irep.iium.edu.my/68353/1/MSSP%202017.pdf http://irep.iium.edu.my/68353/13/353%20MSPP%20prog%20book.pdf http://irep.iium.edu.my/68353/14/353%20PPT_BAPPA.pdf
first_indexed	2023-09-18T21:37:00Z
last_indexed	2023-09-18T21:37:00Z
_version_	1777412887969529856

Direct compressed tablet with melt dispersed drug particle without binder

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