Anticancer activity of acetogenins from Annona muricata fruit
Medicinal plants become very important in our days for their therapeutic benefits to humankind. It sustains human health, and it is commonly known as herbal medicines since ancient times. Annona muricata is a heart-shaped fruit that is consumed raw or as the fruit juice in the tropical area. A. mu...
| Main Authors: | , |
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| Format: | Article |
| Language: | English English English |
| Published: |
IIUM Press
2018
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/68372/ http://irep.iium.edu.my/68372/8/68372_Anticancer%20activity%20of%20acetogenins%20from%20Annona%20muricata%20fruit_ARTICLE.pdf http://irep.iium.edu.my/68372/7/68372_Anticancer%20activity%20of%20acetogenins%20from%20Annona%20muricata%20fruit_SCOPUS.pdf http://irep.iium.edu.my/68372/19/68372%20Anticancer%20Activity%20of%20Acetogenins%20from%20Annona%20Muricata%20Fruit%20WOS.pdf |
| Summary: | Medicinal plants become very important in our days for their therapeutic benefits to humankind. It sustains
human health, and it is commonly known as herbal medicines since ancient times. Annona muricata is a
heart-shaped fruit that is consumed raw or as the fruit juice in the tropical area. A. muricata is used in
traditional and alternative medicine to treat different ailments such as diabetes, hypertension, respiratory
and skin illness, inflammation and cancer. A. muricata contains essential anticancer agents named
acetogenins that play the significant role in various cancer types. Acetogenins are strong nicotinamide
adenine dinucleotide oxidase inhibitors of the cancer cell's mitochondrial membrane but showed neurotoxic
effects in rats. Therefore, acetogenins need to be further investigated to determine the exact mechanisms
of action, long-term safety, optimal dosage, and potential side effects. Given the extensive studies on A.
muricata, this review focuses on the phytochemistry, medicinal uses, biological activities and the
mechanisms of action for the fruit extracts and acetogenins, to stimulate further studies on the fruit pulp
used for human consumption. |
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