Effect of eurycoma longifolia on the testosterone level in adult male rats

Background: aqueous extract of the roots of Eurycoma longifolia (EL) have long been used as an enhancer of male sexual performance. However, data from studies in both human males and experimental male animals on the blood testosterone level in those given the EL extract orally were at best insuffici...

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Main Authors:	Alfaqeh, Hamoud Hussein Mohammed, Mustafa Mahmoud, Mohammed Imad Al-Deen
Format:	Conference or Workshop Item
Language:	English English
Published:	2018
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/68551/ http://irep.iium.edu.my/68551/1/Singapore%20Conference.jpg http://irep.iium.edu.my/68551/6/Singapore%20conference%2020th%20August%202018.pdf

id	iium-68551
recordtype	eprints
spelling	iium-685512018-12-14T08:03:33Z http://irep.iium.edu.my/68551/ Effect of eurycoma longifolia on the testosterone level in adult male rats Alfaqeh, Hamoud Hussein Mohammed Mustafa Mahmoud, Mohammed Imad Al-Deen R Medicine (General) Background: aqueous extract of the roots of Eurycoma longifolia (EL) have long been used as an enhancer of male sexual performance. However, data from studies in both human males and experimental male animals on the blood testosterone level in those given the EL extract orally were at best insufficiently conclusive. Methodology: sixty-four middle age healthy male rats were acclimatized, then randomized into six treated groups and control. The first three treated groups received orally, low (50mg/kg bw), medium (100mg/kg bw) and high doses (200mg/kg bw) of the EL extract for 15 only. The other 3 treated groups continued receiving treatment for 30 days. By the end of each of the study periods, blood samples were collected and the animals were euthanized, dissected, testicles obtained,weighed, and processed for histological examination. Results: The average relative testicular weight in the high and medium dose treated animals was higher than that in the low dose and control groups. Rats which received medium and high oral doses of EL water extract showed increase of spermatogenesis, mature spermatozoa, Sertoli and Leydig cells. The serum testosterone levels were higher among animals that received the medium and high doses for 15days and 30days. Conclusion: The aqueous extract of EL at the medium and high lebel doses demonstrated similar enhancing effect on serum testosterone levels and testicular spermatogenesis. Our findings suggest that the optimal measured effects of EL treatment in adult male rats is the medium dose of 100mg/kg BW given for 15 or 30 days. 2018-08-20 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/68551/1/Singapore%20Conference.jpg application/pdf en http://irep.iium.edu.my/68551/6/Singapore%20conference%2020th%20August%202018.pdf Alfaqeh, Hamoud Hussein Mohammed and Mustafa Mahmoud, Mohammed Imad Al-Deen (2018) Effect of eurycoma longifolia on the testosterone level in adult male rats. In: 289th International Conference on Sports Nutrition and Supplements(ICSNS), 20-21 August 2018, Singapore. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Alfaqeh, Hamoud Hussein Mohammed Mustafa Mahmoud, Mohammed Imad Al-Deen Effect of eurycoma longifolia on the testosterone level in adult male rats
description	Background: aqueous extract of the roots of Eurycoma longifolia (EL) have long been used as an enhancer of male sexual performance. However, data from studies in both human males and experimental male animals on the blood testosterone level in those given the EL extract orally were at best insufficiently conclusive. Methodology: sixty-four middle age healthy male rats were acclimatized, then randomized into six treated groups and control. The first three treated groups received orally, low (50mg/kg bw), medium (100mg/kg bw) and high doses (200mg/kg bw) of the EL extract for 15 only. The other 3 treated groups continued receiving treatment for 30 days. By the end of each of the study periods, blood samples were collected and the animals were euthanized, dissected, testicles obtained,weighed, and processed for histological examination. Results: The average relative testicular weight in the high and medium dose treated animals was higher than that in the low dose and control groups. Rats which received medium and high oral doses of EL water extract showed increase of spermatogenesis, mature spermatozoa, Sertoli and Leydig cells. The serum testosterone levels were higher among animals that received the medium and high doses for 15days and 30days. Conclusion: The aqueous extract of EL at the medium and high lebel doses demonstrated similar enhancing effect on serum testosterone levels and testicular spermatogenesis. Our findings suggest that the optimal measured effects of EL treatment in adult male rats is the medium dose of 100mg/kg BW given for 15 or 30 days.
format	Conference or Workshop Item
author	Alfaqeh, Hamoud Hussein Mohammed Mustafa Mahmoud, Mohammed Imad Al-Deen
author_facet	Alfaqeh, Hamoud Hussein Mohammed Mustafa Mahmoud, Mohammed Imad Al-Deen
author_sort	Alfaqeh, Hamoud Hussein Mohammed
title	Effect of eurycoma longifolia on the testosterone level in adult male rats
title_short	Effect of eurycoma longifolia on the testosterone level in adult male rats
title_full	Effect of eurycoma longifolia on the testosterone level in adult male rats
title_fullStr	Effect of eurycoma longifolia on the testosterone level in adult male rats
title_full_unstemmed	Effect of eurycoma longifolia on the testosterone level in adult male rats
title_sort	effect of eurycoma longifolia on the testosterone level in adult male rats
publishDate	2018
url	http://irep.iium.edu.my/68551/ http://irep.iium.edu.my/68551/1/Singapore%20Conference.jpg http://irep.iium.edu.my/68551/6/Singapore%20conference%2020th%20August%202018.pdf
first_indexed	2023-09-18T21:37:17Z
last_indexed	2023-09-18T21:37:17Z
_version_	1777412905559392256

Effect of eurycoma longifolia on the testosterone level in adult male rats

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