Alkaloids from alphonsea elliptica barks and their biological activities

This study was carried out to investigate the phytochemicals from the barks of Alphonsea elliptica. The barks were harvested from Hutan Simpan Sembarong, Kluang, Johor; and extracted using dichloromethane (DCM), hexane and methanol successively. Isolation of dichloromethane crude extract was then pe...

Full description

Bibliographic Details
Main Authors:	Obaid, Ahmed Kareem, Syed Abdul Azziz, Saripah Salbiah, Mhd Bakri, Yuhanis, Nafiah, Mohd Azlan, Awang, Khalijah, Abdulla Aowda, Saadon, Litaudon, Marc, Mohd Hassan, Norazian, Naz, Humera, Abbas, Phirdaous, Hashim, Yumi Zuhanis Has-Yun, Majhool, Alhussein Arkan
Format:	Article
Language:	English English
Published:	Mason Publishing 2018
Subjects:	QD Chemistry RS403 Materia Medica-Pharmaceutical Chemistry
Online Access:	http://irep.iium.edu.my/68590/ http://irep.iium.edu.my/68590/ http://irep.iium.edu.my/68590/1/68590_Alkaloids%20from%20Alphonsea%20elliptica.pdf http://irep.iium.edu.my/68590/2/68590_Alkaloids%20from%20Alphonsea%20elliptica_SCOPUS.pdf

id	iium-68590
recordtype	eprints
spelling	iium-685902019-02-12T08:33:11Z http://irep.iium.edu.my/68590/ Alkaloids from alphonsea elliptica barks and their biological activities Obaid, Ahmed Kareem Syed Abdul Azziz, Saripah Salbiah Mhd Bakri, Yuhanis Nafiah, Mohd Azlan Awang, Khalijah Abdulla Aowda, Saadon Litaudon, Marc Mohd Hassan, Norazian Naz, Humera Abbas, Phirdaous Hashim, Yumi Zuhanis Has-Yun Majhool, Alhussein Arkan QD Chemistry RS403 Materia Medica-Pharmaceutical Chemistry This study was carried out to investigate the phytochemicals from the barks of Alphonsea elliptica. The barks were harvested from Hutan Simpan Sembarong, Kluang, Johor; and extracted using dichloromethane (DCM), hexane and methanol successively. Isolation of dichloromethane crude extract was then performed using silica gel column chromatography and preparative thin layer chromatography (PTLC) techniques. Structural identification were carried out via 1D and 2D NMR, UV, IR, MS and comparison with reported data. Phytochemical study of the barks led to the isolation of five alkaloid in which two were oxoaporphines; atherospermidine (1) and liriodenine (2),two were dioxoaporphines;cepharadione A (3) and N-methylouregidione (4), and an azafluorenone alkaloid; kinabaline (5). The hexane, DCM, and methanol crude extracts, together with five isolated alkaloids, were tested for their radical scavenging activity, inhibition of xanthine oxidase activities and cytotoxicity. Atherospermidine and liriodenine possessed antioxidative activities with IC50 value of 20.17 and 10.73, respectively. Atherospermidine, liriodenine, N-methylouregidione and kinabaline showed xanthine oxidase inhibitiory activityof 46.29, 7.66, 42.10 and 50.72 μM,respectively. Meanwhile, atherospermidine, liriodenine, cepharadione A and kinabaline showed cytotoxicity against breast cancer cell line with IC50 89, 86, 79.85 and 62 μg/mL respectively. All the alkaloids tested in this study were isolated for the first time from this species while cepharadione A is reported for the first time in a species belongs to Alphonsea genus. Mason Publishing 2018 Article PeerReviewed application/pdf en http://irep.iium.edu.my/68590/1/68590_Alkaloids%20from%20Alphonsea%20elliptica.pdf application/pdf en http://irep.iium.edu.my/68590/2/68590_Alkaloids%20from%20Alphonsea%20elliptica_SCOPUS.pdf Obaid, Ahmed Kareem and Syed Abdul Azziz, Saripah Salbiah and Mhd Bakri, Yuhanis and Nafiah, Mohd Azlan and Awang, Khalijah and Abdulla Aowda, Saadon and Litaudon, Marc and Mohd Hassan, Norazian and Naz, Humera and Abbas, Phirdaous and Hashim, Yumi Zuhanis Has-Yun and Majhool, Alhussein Arkan (2018) Alkaloids from alphonsea elliptica barks and their biological activities. Journal of Global Pharma Technology, 10 (8). pp. 270-275. ISSN 0975-8542 http://www.jgpt.co.in/index.php/jgpt/article/view/1359/994
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QD Chemistry RS403 Materia Medica-Pharmaceutical Chemistry
spellingShingle	QD Chemistry RS403 Materia Medica-Pharmaceutical Chemistry Obaid, Ahmed Kareem Syed Abdul Azziz, Saripah Salbiah Mhd Bakri, Yuhanis Nafiah, Mohd Azlan Awang, Khalijah Abdulla Aowda, Saadon Litaudon, Marc Mohd Hassan, Norazian Naz, Humera Abbas, Phirdaous Hashim, Yumi Zuhanis Has-Yun Majhool, Alhussein Arkan Alkaloids from alphonsea elliptica barks and their biological activities
description	This study was carried out to investigate the phytochemicals from the barks of Alphonsea elliptica. The barks were harvested from Hutan Simpan Sembarong, Kluang, Johor; and extracted using dichloromethane (DCM), hexane and methanol successively. Isolation of dichloromethane crude extract was then performed using silica gel column chromatography and preparative thin layer chromatography (PTLC) techniques. Structural identification were carried out via 1D and 2D NMR, UV, IR, MS and comparison with reported data. Phytochemical study of the barks led to the isolation of five alkaloid in which two were oxoaporphines; atherospermidine (1) and liriodenine (2),two were dioxoaporphines;cepharadione A (3) and N-methylouregidione (4), and an azafluorenone alkaloid; kinabaline (5). The hexane, DCM, and methanol crude extracts, together with five isolated alkaloids, were tested for their radical scavenging activity, inhibition of xanthine oxidase activities and cytotoxicity. Atherospermidine and liriodenine possessed antioxidative activities with IC50 value of 20.17 and 10.73, respectively. Atherospermidine, liriodenine, N-methylouregidione and kinabaline showed xanthine oxidase inhibitiory activityof 46.29, 7.66, 42.10 and 50.72 μM,respectively. Meanwhile, atherospermidine, liriodenine, cepharadione A and kinabaline showed cytotoxicity against breast cancer cell line with IC50 89, 86, 79.85 and 62 μg/mL respectively. All the alkaloids tested in this study were isolated for the first time from this species while cepharadione A is reported for the first time in a species belongs to Alphonsea genus.
format	Article
author	Obaid, Ahmed Kareem Syed Abdul Azziz, Saripah Salbiah Mhd Bakri, Yuhanis Nafiah, Mohd Azlan Awang, Khalijah Abdulla Aowda, Saadon Litaudon, Marc Mohd Hassan, Norazian Naz, Humera Abbas, Phirdaous Hashim, Yumi Zuhanis Has-Yun Majhool, Alhussein Arkan
author_facet	Obaid, Ahmed Kareem Syed Abdul Azziz, Saripah Salbiah Mhd Bakri, Yuhanis Nafiah, Mohd Azlan Awang, Khalijah Abdulla Aowda, Saadon Litaudon, Marc Mohd Hassan, Norazian Naz, Humera Abbas, Phirdaous Hashim, Yumi Zuhanis Has-Yun Majhool, Alhussein Arkan
author_sort	Obaid, Ahmed Kareem
title	Alkaloids from alphonsea elliptica barks and their biological activities
title_short	Alkaloids from alphonsea elliptica barks and their biological activities
title_full	Alkaloids from alphonsea elliptica barks and their biological activities
title_fullStr	Alkaloids from alphonsea elliptica barks and their biological activities
title_full_unstemmed	Alkaloids from alphonsea elliptica barks and their biological activities
title_sort	alkaloids from alphonsea elliptica barks and their biological activities
publisher	Mason Publishing
publishDate	2018
url	http://irep.iium.edu.my/68590/ http://irep.iium.edu.my/68590/ http://irep.iium.edu.my/68590/1/68590_Alkaloids%20from%20Alphonsea%20elliptica.pdf http://irep.iium.edu.my/68590/2/68590_Alkaloids%20from%20Alphonsea%20elliptica_SCOPUS.pdf
first_indexed	2023-09-18T21:37:20Z
last_indexed	2023-09-18T21:37:20Z
_version_	1777412908814172160

Alkaloids from alphonsea elliptica barks and their biological activities

Similar Items