The biflavonoids, amentoflavone degrades calf thymus DNA in the presence of copper ions

Previous reports from this laboratory have shown that flavonoids including apigenin are capable of inducing oxidative DNA cleavage in the presence of copper ions. In the present report, we have examined the ability of amentoflavone, a biflavonoid which is a dimer of apigenin, to catalyze the degrada...

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Main Authors:	Ahmed, Qamar Uddin, Malik, Arshi, Azam, Sonish, Hadi, Naghma, Azmi, Asfar Sohail, Parveen, Nazneen, Khan, Nizam Ud Din, Hadi, Sheikh Mumtaz
Format:	Article
Language:	English
Published:	Elsevier Science 2004
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/68936/ http://irep.iium.edu.my/68936/ http://irep.iium.edu.my/68936/1/Toxicology%20in%20vitro_The_biflavonoid_amentoflavone_degrades_D.pdf

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recordtype	eprints
spelling	iium-689362019-01-02T00:12:43Z http://irep.iium.edu.my/68936/ The biflavonoids, amentoflavone degrades calf thymus DNA in the presence of copper ions Ahmed, Qamar Uddin Malik, Arshi Azam, Sonish Hadi, Naghma Azmi, Asfar Sohail Parveen, Nazneen Khan, Nizam Ud Din Hadi, Sheikh Mumtaz Q Science (General) Previous reports from this laboratory have shown that flavonoids including apigenin are capable of inducing oxidative DNA cleavage in the presence of copper ions. In the present report, we have examined the ability of amentoflavone, a biflavonoid which is a dimer of apigenin, to catalyze the degradation of DNA. Amentoflavone was found to degrade calf thymus DNA in the presence of Cu(II) at a rate almost twice that of apigenin. Amentoflavone was also shown to reduce Cu(II) to Cu(I) and to generate hydroxyl radicals in the presence of copper ions. In the presence of Cu(II), the absorption spectrum of amentoflavone undergoes a shift and a quenching effect indicating that the biflavonoid is capable of binding to copper ions. Amentoflavone and apigenin were isolated from Cycas rumphii and Trifolium alexandrinum, respectively. The results are discussed in relation to the putative chemopreventive mechanism of amentoflavone. Elsevier Science 2004 Article PeerReviewed application/pdf en http://irep.iium.edu.my/68936/1/Toxicology%20in%20vitro_The_biflavonoid_amentoflavone_degrades_D.pdf Ahmed, Qamar Uddin and Malik, Arshi and Azam, Sonish and Hadi, Naghma and Azmi, Asfar Sohail and Parveen, Nazneen and Khan, Nizam Ud Din and Hadi, Sheikh Mumtaz (2004) The biflavonoids, amentoflavone degrades calf thymus DNA in the presence of copper ions. Toxicology in Vitro, 18 (4). pp. 435-440. ISSN 0887-2333 10.1016/j.tiv.2003.12.009
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	Q Science (General)
spellingShingle	Q Science (General) Ahmed, Qamar Uddin Malik, Arshi Azam, Sonish Hadi, Naghma Azmi, Asfar Sohail Parveen, Nazneen Khan, Nizam Ud Din Hadi, Sheikh Mumtaz The biflavonoids, amentoflavone degrades calf thymus DNA in the presence of copper ions
description	Previous reports from this laboratory have shown that flavonoids including apigenin are capable of inducing oxidative DNA cleavage in the presence of copper ions. In the present report, we have examined the ability of amentoflavone, a biflavonoid which is a dimer of apigenin, to catalyze the degradation of DNA. Amentoflavone was found to degrade calf thymus DNA in the presence of Cu(II) at a rate almost twice that of apigenin. Amentoflavone was also shown to reduce Cu(II) to Cu(I) and to generate hydroxyl radicals in the presence of copper ions. In the presence of Cu(II), the absorption spectrum of amentoflavone undergoes a shift and a quenching effect indicating that the biflavonoid is capable of binding to copper ions. Amentoflavone and apigenin were isolated from Cycas rumphii and Trifolium alexandrinum, respectively. The results are discussed in relation to the putative chemopreventive mechanism of amentoflavone.
format	Article
author	Ahmed, Qamar Uddin Malik, Arshi Azam, Sonish Hadi, Naghma Azmi, Asfar Sohail Parveen, Nazneen Khan, Nizam Ud Din Hadi, Sheikh Mumtaz
author_facet	Ahmed, Qamar Uddin Malik, Arshi Azam, Sonish Hadi, Naghma Azmi, Asfar Sohail Parveen, Nazneen Khan, Nizam Ud Din Hadi, Sheikh Mumtaz
author_sort	Ahmed, Qamar Uddin
title	The biflavonoids, amentoflavone degrades calf thymus DNA in the presence of copper ions
title_short	The biflavonoids, amentoflavone degrades calf thymus DNA in the presence of copper ions
title_full	The biflavonoids, amentoflavone degrades calf thymus DNA in the presence of copper ions
title_fullStr	The biflavonoids, amentoflavone degrades calf thymus DNA in the presence of copper ions
title_full_unstemmed	The biflavonoids, amentoflavone degrades calf thymus DNA in the presence of copper ions
title_sort	biflavonoids, amentoflavone degrades calf thymus dna in the presence of copper ions
publisher	Elsevier Science
publishDate	2004
url	http://irep.iium.edu.my/68936/ http://irep.iium.edu.my/68936/ http://irep.iium.edu.my/68936/1/Toxicology%20in%20vitro_The_biflavonoid_amentoflavone_degrades_D.pdf
first_indexed	2023-09-18T21:37:50Z
last_indexed	2023-09-18T21:37:50Z
_version_	1777412939772329984

The biflavonoids, amentoflavone degrades calf thymus DNA in the presence of copper ions

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