Is asiaticoside effective against pain?

Centella asiatica or locally known as “Pegaga” is a well-known herb that has been used in folklore medicine for centuries to treat skin problem, asthma, sstomach disorder and to improve memory. Moreover, Centella asiatica extracts exhibited significant antinocicetive activities at the central and pe...

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Main Authors:	Mohammad, Rasyidah Ryta Ayumi, Shaik Mohamed Mossadeq, Wan Mastura, Zakaria, Zainul Amiruddin, Bakhtiar, M. Taher
Format:	Conference or Workshop Item
Language:	English
Published:	Universiti Kebangsaan Malaysia 2018
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/68950/ http://irep.iium.edu.my/68950/ http://irep.iium.edu.my/68950/1/ayumi_MSAB2018.pdf

id	iium-68950
recordtype	eprints
spelling	iium-689502019-07-03T07:28:41Z http://irep.iium.edu.my/68950/ Is asiaticoside effective against pain? Mohammad, Rasyidah Ryta Ayumi Shaik Mohamed Mossadeq, Wan Mastura Zakaria, Zainul Amiruddin Bakhtiar, M. Taher RS Pharmacy and materia medica Centella asiatica or locally known as “Pegaga” is a well-known herb that has been used in folklore medicine for centuries to treat skin problem, asthma, sstomach disorder and to improve memory. Moreover, Centella asiatica extracts exhibited significant antinocicetive activities at the central and peripheral levels. This , this research aimed to evaluate the antinociceptive activities of asiaticoside, the main bioactive constituent of Centella asiatica. We evaluated the effect of asiaticoside (1,3,5 and 10 mg/kg, orally) on the acetic acid induced abdominal constriction test and the hot plate test in mice. Our data showed that the highest dose of asiticoside (10 mg/kg) significantly (p<0.05) inhibited the abdiomial constrictions by 58.3%. Moreover, asiaticoside prolongied the latency (sec) spent by each mouse on he hot plate surface. In conclusion, asiaticoside induces analgesia at the central and peripheral levels. Further studies are required to elucidate its mechanism(s) of action. Universiti Kebangsaan Malaysia 2018 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/68950/1/ayumi_MSAB2018.pdf Mohammad, Rasyidah Ryta Ayumi and Shaik Mohamed Mossadeq, Wan Mastura and Zakaria, Zainul Amiruddin and Bakhtiar, M. Taher (2018) Is asiaticoside effective against pain? In: 15th Symposium of The Malaysian Society of Applied Biology, 29th June-1st July 2018, Melaka. http://msabsimposium.blogspot.com/2018/01/the-15th-symposium-malaysian-society-of.html
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Mohammad, Rasyidah Ryta Ayumi Shaik Mohamed Mossadeq, Wan Mastura Zakaria, Zainul Amiruddin Bakhtiar, M. Taher Is asiaticoside effective against pain?
description	Centella asiatica or locally known as “Pegaga” is a well-known herb that has been used in folklore medicine for centuries to treat skin problem, asthma, sstomach disorder and to improve memory. Moreover, Centella asiatica extracts exhibited significant antinocicetive activities at the central and peripheral levels. This , this research aimed to evaluate the antinociceptive activities of asiaticoside, the main bioactive constituent of Centella asiatica. We evaluated the effect of asiaticoside (1,3,5 and 10 mg/kg, orally) on the acetic acid induced abdominal constriction test and the hot plate test in mice. Our data showed that the highest dose of asiticoside (10 mg/kg) significantly (p<0.05) inhibited the abdiomial constrictions by 58.3%. Moreover, asiaticoside prolongied the latency (sec) spent by each mouse on he hot plate surface. In conclusion, asiaticoside induces analgesia at the central and peripheral levels. Further studies are required to elucidate its mechanism(s) of action.
format	Conference or Workshop Item
author	Mohammad, Rasyidah Ryta Ayumi Shaik Mohamed Mossadeq, Wan Mastura Zakaria, Zainul Amiruddin Bakhtiar, M. Taher
author_facet	Mohammad, Rasyidah Ryta Ayumi Shaik Mohamed Mossadeq, Wan Mastura Zakaria, Zainul Amiruddin Bakhtiar, M. Taher
author_sort	Mohammad, Rasyidah Ryta Ayumi
title	Is asiaticoside effective against pain?
title_short	Is asiaticoside effective against pain?
title_full	Is asiaticoside effective against pain?
title_fullStr	Is asiaticoside effective against pain?
title_full_unstemmed	Is asiaticoside effective against pain?
title_sort	is asiaticoside effective against pain?
publisher	Universiti Kebangsaan Malaysia
publishDate	2018
url	http://irep.iium.edu.my/68950/ http://irep.iium.edu.my/68950/ http://irep.iium.edu.my/68950/1/ayumi_MSAB2018.pdf
first_indexed	2023-09-18T21:37:51Z
last_indexed	2023-09-18T21:37:51Z
_version_	1777412941056835584

Is asiaticoside effective against pain?

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