Encapsulation and characterization of gentamicin sulfate in the collagen added electrospun nanofibers for skin regeneration

In the current practice, the clinical use of conventional skin substitutes such as autogenous skin grafts have shown several problems, mainly with respect to limited sources and donor site morbidity. In order to overcome these limitations, the use of smart synthetic biomaterials is tremendously diff...

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Main Authors:	Wan Abdul Khodir, Wan Kartini, Abdul Razak, Abdul Hakim, Ng, Min Hwei, Guarino, Vincenzo, Darnis, Deny Susanti
Format:	Article
Language:	English
Published:	MDPI 2018
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/68958/ http://irep.iium.edu.my/68958/ http://irep.iium.edu.my/68958/ http://irep.iium.edu.my/68958/1/WK%20et%20al%202018%20jfb-09-00036.pdf

id	iium-68958
recordtype	eprints
spelling	iium-689582019-01-07T07:11:30Z http://irep.iium.edu.my/68958/ Encapsulation and characterization of gentamicin sulfate in the collagen added electrospun nanofibers for skin regeneration Wan Abdul Khodir, Wan Kartini Abdul Razak, Abdul Hakim Ng, Min Hwei Guarino, Vincenzo Darnis, Deny Susanti QD Chemistry In the current practice, the clinical use of conventional skin substitutes such as autogenous skin grafts have shown several problems, mainly with respect to limited sources and donor site morbidity. In order to overcome these limitations, the use of smart synthetic biomaterials is tremendously diffusing as skin substitutes. Indeed, engineered skin grafts or analogues frequently play an important role in the treatment of chronic skin wounds, by supporting the regeneration of newly formed tissue, and at the same time preventing infections during the long-term treatment. In this context, natural proteins such as collagen—natively present in the skin tissue—embedded in synthetic polymers (i.e., PCL) allow the development of micro-structured matrices able to mimic the functions and to structure of the surrounding extracellular matrix. Moreover, the encapsulation of drugs, such as gentamicin sulfate, also improves the bioactivity of nanofibers, due to the efficient loading and a controlled drug release towards the site of interest. Herein, we have done a preliminary investigation on the capability of gentamicin sulfate, loaded into collagen-added nanofibers, for the controlled release in local infection treatments. Experimental studies have demonstrated that collagen added fibers can be efficaciously used to administrate gentamicin for 72 h without any toxic in vitro response, thus emerging as a valid candidate for the therapeutic treatment of infected wounds. MDPI 2018-05-18 Article PeerReviewed application/pdf en http://irep.iium.edu.my/68958/1/WK%20et%20al%202018%20jfb-09-00036.pdf Wan Abdul Khodir, Wan Kartini and Abdul Razak, Abdul Hakim and Ng, Min Hwei and Guarino, Vincenzo and Darnis, Deny Susanti (2018) Encapsulation and characterization of gentamicin sulfate in the collagen added electrospun nanofibers for skin regeneration. Journal of Functional Biomaterials, 9 (2). pp. 1-9. ISSN 2079-4983 https://www.mdpi.com/2079-4983/9/2/36/htm 10.3390/jfb9020036
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Wan Abdul Khodir, Wan Kartini Abdul Razak, Abdul Hakim Ng, Min Hwei Guarino, Vincenzo Darnis, Deny Susanti Encapsulation and characterization of gentamicin sulfate in the collagen added electrospun nanofibers for skin regeneration
description	In the current practice, the clinical use of conventional skin substitutes such as autogenous skin grafts have shown several problems, mainly with respect to limited sources and donor site morbidity. In order to overcome these limitations, the use of smart synthetic biomaterials is tremendously diffusing as skin substitutes. Indeed, engineered skin grafts or analogues frequently play an important role in the treatment of chronic skin wounds, by supporting the regeneration of newly formed tissue, and at the same time preventing infections during the long-term treatment. In this context, natural proteins such as collagen—natively present in the skin tissue—embedded in synthetic polymers (i.e., PCL) allow the development of micro-structured matrices able to mimic the functions and to structure of the surrounding extracellular matrix. Moreover, the encapsulation of drugs, such as gentamicin sulfate, also improves the bioactivity of nanofibers, due to the efficient loading and a controlled drug release towards the site of interest. Herein, we have done a preliminary investigation on the capability of gentamicin sulfate, loaded into collagen-added nanofibers, for the controlled release in local infection treatments. Experimental studies have demonstrated that collagen added fibers can be efficaciously used to administrate gentamicin for 72 h without any toxic in vitro response, thus emerging as a valid candidate for the therapeutic treatment of infected wounds.
format	Article
author	Wan Abdul Khodir, Wan Kartini Abdul Razak, Abdul Hakim Ng, Min Hwei Guarino, Vincenzo Darnis, Deny Susanti
author_facet	Wan Abdul Khodir, Wan Kartini Abdul Razak, Abdul Hakim Ng, Min Hwei Guarino, Vincenzo Darnis, Deny Susanti
author_sort	Wan Abdul Khodir, Wan Kartini
title	Encapsulation and characterization of gentamicin sulfate in the collagen added electrospun nanofibers for skin regeneration
title_short	Encapsulation and characterization of gentamicin sulfate in the collagen added electrospun nanofibers for skin regeneration
title_full	Encapsulation and characterization of gentamicin sulfate in the collagen added electrospun nanofibers for skin regeneration
title_fullStr	Encapsulation and characterization of gentamicin sulfate in the collagen added electrospun nanofibers for skin regeneration
title_full_unstemmed	Encapsulation and characterization of gentamicin sulfate in the collagen added electrospun nanofibers for skin regeneration
title_sort	encapsulation and characterization of gentamicin sulfate in the collagen added electrospun nanofibers for skin regeneration
publisher	MDPI
publishDate	2018
url	http://irep.iium.edu.my/68958/ http://irep.iium.edu.my/68958/ http://irep.iium.edu.my/68958/ http://irep.iium.edu.my/68958/1/WK%20et%20al%202018%20jfb-09-00036.pdf
first_indexed	2023-09-18T21:37:52Z
last_indexed	2023-09-18T21:37:52Z
_version_	1777412941757284352

Encapsulation and characterization of gentamicin sulfate in the collagen added electrospun nanofibers for skin regeneration

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