Encapsulation and characterization of gentamicin sulfate in the collagen added electrospun nanofibers for skin regeneration

In the current practice, the clinical use of conventional skin substitutes such as autogenous skin grafts have shown several problems, mainly with respect to limited sources and donor site morbidity. In order to overcome these limitations, the use of smart synthetic biomaterials is tremendously diff...

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Main Authors: Wan Abdul Khodir, Wan Kartini, Abdul Razak, Abdul Hakim, Ng, Min Hwei, Guarino, Vincenzo, Darnis, Deny Susanti
Format: Article
Language:English
Published: MDPI 2018
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Online Access:http://irep.iium.edu.my/68958/
http://irep.iium.edu.my/68958/
http://irep.iium.edu.my/68958/
http://irep.iium.edu.my/68958/1/WK%20et%20al%202018%20jfb-09-00036.pdf
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spelling iium-689582019-01-07T07:11:30Z http://irep.iium.edu.my/68958/ Encapsulation and characterization of gentamicin sulfate in the collagen added electrospun nanofibers for skin regeneration Wan Abdul Khodir, Wan Kartini Abdul Razak, Abdul Hakim Ng, Min Hwei Guarino, Vincenzo Darnis, Deny Susanti QD Chemistry In the current practice, the clinical use of conventional skin substitutes such as autogenous skin grafts have shown several problems, mainly with respect to limited sources and donor site morbidity. In order to overcome these limitations, the use of smart synthetic biomaterials is tremendously diffusing as skin substitutes. Indeed, engineered skin grafts or analogues frequently play an important role in the treatment of chronic skin wounds, by supporting the regeneration of newly formed tissue, and at the same time preventing infections during the long-term treatment. In this context, natural proteins such as collagen—natively present in the skin tissue—embedded in synthetic polymers (i.e., PCL) allow the development of micro-structured matrices able to mimic the functions and to structure of the surrounding extracellular matrix. Moreover, the encapsulation of drugs, such as gentamicin sulfate, also improves the bioactivity of nanofibers, due to the efficient loading and a controlled drug release towards the site of interest. Herein, we have done a preliminary investigation on the capability of gentamicin sulfate, loaded into collagen-added nanofibers, for the controlled release in local infection treatments. Experimental studies have demonstrated that collagen added fibers can be efficaciously used to administrate gentamicin for 72 h without any toxic in vitro response, thus emerging as a valid candidate for the therapeutic treatment of infected wounds. MDPI 2018-05-18 Article PeerReviewed application/pdf en http://irep.iium.edu.my/68958/1/WK%20et%20al%202018%20jfb-09-00036.pdf Wan Abdul Khodir, Wan Kartini and Abdul Razak, Abdul Hakim and Ng, Min Hwei and Guarino, Vincenzo and Darnis, Deny Susanti (2018) Encapsulation and characterization of gentamicin sulfate in the collagen added electrospun nanofibers for skin regeneration. Journal of Functional Biomaterials, 9 (2). pp. 1-9. ISSN 2079-4983 https://www.mdpi.com/2079-4983/9/2/36/htm 10.3390/jfb9020036
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic QD Chemistry
spellingShingle QD Chemistry
Wan Abdul Khodir, Wan Kartini
Abdul Razak, Abdul Hakim
Ng, Min Hwei
Guarino, Vincenzo
Darnis, Deny Susanti
Encapsulation and characterization of gentamicin sulfate in the collagen added electrospun nanofibers for skin regeneration
description In the current practice, the clinical use of conventional skin substitutes such as autogenous skin grafts have shown several problems, mainly with respect to limited sources and donor site morbidity. In order to overcome these limitations, the use of smart synthetic biomaterials is tremendously diffusing as skin substitutes. Indeed, engineered skin grafts or analogues frequently play an important role in the treatment of chronic skin wounds, by supporting the regeneration of newly formed tissue, and at the same time preventing infections during the long-term treatment. In this context, natural proteins such as collagen—natively present in the skin tissue—embedded in synthetic polymers (i.e., PCL) allow the development of micro-structured matrices able to mimic the functions and to structure of the surrounding extracellular matrix. Moreover, the encapsulation of drugs, such as gentamicin sulfate, also improves the bioactivity of nanofibers, due to the efficient loading and a controlled drug release towards the site of interest. Herein, we have done a preliminary investigation on the capability of gentamicin sulfate, loaded into collagen-added nanofibers, for the controlled release in local infection treatments. Experimental studies have demonstrated that collagen added fibers can be efficaciously used to administrate gentamicin for 72 h without any toxic in vitro response, thus emerging as a valid candidate for the therapeutic treatment of infected wounds.
format Article
author Wan Abdul Khodir, Wan Kartini
Abdul Razak, Abdul Hakim
Ng, Min Hwei
Guarino, Vincenzo
Darnis, Deny Susanti
author_facet Wan Abdul Khodir, Wan Kartini
Abdul Razak, Abdul Hakim
Ng, Min Hwei
Guarino, Vincenzo
Darnis, Deny Susanti
author_sort Wan Abdul Khodir, Wan Kartini
title Encapsulation and characterization of gentamicin sulfate in the collagen added electrospun nanofibers for skin regeneration
title_short Encapsulation and characterization of gentamicin sulfate in the collagen added electrospun nanofibers for skin regeneration
title_full Encapsulation and characterization of gentamicin sulfate in the collagen added electrospun nanofibers for skin regeneration
title_fullStr Encapsulation and characterization of gentamicin sulfate in the collagen added electrospun nanofibers for skin regeneration
title_full_unstemmed Encapsulation and characterization of gentamicin sulfate in the collagen added electrospun nanofibers for skin regeneration
title_sort encapsulation and characterization of gentamicin sulfate in the collagen added electrospun nanofibers for skin regeneration
publisher MDPI
publishDate 2018
url http://irep.iium.edu.my/68958/
http://irep.iium.edu.my/68958/
http://irep.iium.edu.my/68958/
http://irep.iium.edu.my/68958/1/WK%20et%20al%202018%20jfb-09-00036.pdf
first_indexed 2023-09-18T21:37:52Z
last_indexed 2023-09-18T21:37:52Z
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