Prediction on binding affinity of nordentatin and quercetin against anti-apoptotic BCL-2 protein

Targeting apoptotic cell-death pathways has been a subject of growing interest in discovery of novel anti-cancer agents. Bcl-2 is a member of Bcl-2 family protein that is crucial for cell survival by supressing apoptosis and its overexpression is frequently detected in many type of cancers. Inactiv...

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Main Authors:	Afriza, Dhona, Ichwan, Solachuddin J. A., Suriyah, Wastuti Hidayati, Wahyuni, Fatma Suri, ., Yanwirasti, Tejo, Bimo Ario
Format:	Article
Language:	English English
Published:	Ectodermal Dysplasia Group Turkey 2018
Subjects:	R Medicine (General) RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/69230/ http://irep.iium.edu.my/69230/ http://irep.iium.edu.my/69230/1/69230_Prediction%20on%20Binding%20Affinity%20of%20Nordentatin.pdf http://irep.iium.edu.my/69230/2/69230_Prediction%20on%20Binding%20Affinity%20of%20Nordentatin_SCOPUS.pdf

id	iium-69230
recordtype	eprints
spelling	iium-692302019-01-16T08:18:47Z http://irep.iium.edu.my/69230/ Prediction on binding affinity of nordentatin and quercetin against anti-apoptotic BCL-2 protein Afriza, Dhona Ichwan, Solachuddin J. A. Suriyah, Wastuti Hidayati Wahyuni, Fatma Suri ., Yanwirasti Tejo, Bimo Ario R Medicine (General) RS Pharmacy and materia medica Targeting apoptotic cell-death pathways has been a subject of growing interest in discovery of novel anti-cancer agents. Bcl-2 is a member of Bcl-2 family protein that is crucial for cell survival by supressing apoptosis and its overexpression is frequently detected in many type of cancers. Inactivation of Bcl-2 has been considered as an ideal strategy in anti-cancer therapies. A large number of bioactive compounds derived from natural source including Nordentatin and Quercetin have been reported to possess anticancer activities. Here we report the binding affinities of Nordentatin and Quercetin in silico against anti-apoptotic Bcl-2 protein using molecular docking programs. We demonstrate for the first time that Nordentatin showed optimum binding affinity with Bcl-2, similar to those shown by Quercetin. As the Quercetin has been previously known to play a role in cancer cell apoptosis through down-regulation of Bcl-2, the result indicated that Nordentatin could also be proposed as a prospective anticancer molecule via inhibition of Bcl-2 protein. Ectodermal Dysplasia Group Turkey 2018 Article PeerReviewed application/pdf en http://irep.iium.edu.my/69230/1/69230_Prediction%20on%20Binding%20Affinity%20of%20Nordentatin.pdf application/pdf en http://irep.iium.edu.my/69230/2/69230_Prediction%20on%20Binding%20Affinity%20of%20Nordentatin_SCOPUS.pdf Afriza, Dhona and Ichwan, Solachuddin J. A. and Suriyah, Wastuti Hidayati and Wahyuni, Fatma Suri and ., Yanwirasti and Tejo, Bimo Ario (2018) Prediction on binding affinity of nordentatin and quercetin against anti-apoptotic BCL-2 protein. Journal of International Dental and Medical Research, 11 (3). pp. 1116-1122. E-ISSN 1309-100X http://www.jidmr.com/journal/wp-content/uploads/2019/01/64_M18_654_Solachuddin_J_A_Ichwan.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	R Medicine (General) RS Pharmacy and materia medica
spellingShingle	R Medicine (General) RS Pharmacy and materia medica Afriza, Dhona Ichwan, Solachuddin J. A. Suriyah, Wastuti Hidayati Wahyuni, Fatma Suri ., Yanwirasti Tejo, Bimo Ario Prediction on binding affinity of nordentatin and quercetin against anti-apoptotic BCL-2 protein
description	Targeting apoptotic cell-death pathways has been a subject of growing interest in discovery of novel anti-cancer agents. Bcl-2 is a member of Bcl-2 family protein that is crucial for cell survival by supressing apoptosis and its overexpression is frequently detected in many type of cancers. Inactivation of Bcl-2 has been considered as an ideal strategy in anti-cancer therapies. A large number of bioactive compounds derived from natural source including Nordentatin and Quercetin have been reported to possess anticancer activities. Here we report the binding affinities of Nordentatin and Quercetin in silico against anti-apoptotic Bcl-2 protein using molecular docking programs. We demonstrate for the first time that Nordentatin showed optimum binding affinity with Bcl-2, similar to those shown by Quercetin. As the Quercetin has been previously known to play a role in cancer cell apoptosis through down-regulation of Bcl-2, the result indicated that Nordentatin could also be proposed as a prospective anticancer molecule via inhibition of Bcl-2 protein.
format	Article
author	Afriza, Dhona Ichwan, Solachuddin J. A. Suriyah, Wastuti Hidayati Wahyuni, Fatma Suri ., Yanwirasti Tejo, Bimo Ario
author_facet	Afriza, Dhona Ichwan, Solachuddin J. A. Suriyah, Wastuti Hidayati Wahyuni, Fatma Suri ., Yanwirasti Tejo, Bimo Ario
author_sort	Afriza, Dhona
title	Prediction on binding affinity of nordentatin and quercetin against anti-apoptotic BCL-2 protein
title_short	Prediction on binding affinity of nordentatin and quercetin against anti-apoptotic BCL-2 protein
title_full	Prediction on binding affinity of nordentatin and quercetin against anti-apoptotic BCL-2 protein
title_fullStr	Prediction on binding affinity of nordentatin and quercetin against anti-apoptotic BCL-2 protein
title_full_unstemmed	Prediction on binding affinity of nordentatin and quercetin against anti-apoptotic BCL-2 protein
title_sort	prediction on binding affinity of nordentatin and quercetin against anti-apoptotic bcl-2 protein
publisher	Ectodermal Dysplasia Group Turkey
publishDate	2018
url	http://irep.iium.edu.my/69230/ http://irep.iium.edu.my/69230/ http://irep.iium.edu.my/69230/1/69230_Prediction%20on%20Binding%20Affinity%20of%20Nordentatin.pdf http://irep.iium.edu.my/69230/2/69230_Prediction%20on%20Binding%20Affinity%20of%20Nordentatin_SCOPUS.pdf
first_indexed	2023-09-18T21:38:16Z
last_indexed	2023-09-18T21:38:16Z
_version_	1777412966943031296

Prediction on binding affinity of nordentatin and quercetin against anti-apoptotic BCL-2 protein

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