Topographical changes of rat's colonic mucosal after chronic arsenic exposure - A scanning electron microscopy study

Introduction: Human are exposed to arsenic threats in several ways. Our drinking water for instance, can be hazardous due to the contamination of arsenic-based pesticide and herbicide into our water supply. The most vulnerable part of our body due to ingestion of arsenic is our gastrointestinal syst...

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Main Authors:	Zulkiflee, Khodijah, Buyong, Zunariah, Hamdan, Asmah Hanim, Saharudin, Shahida, Wan Salleh, Wan Muhamad Salahudin
Format:	Article
Language:	English
Published:	Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia 2018
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/69253/ http://irep.iium.edu.my/69253/ http://irep.iium.edu.my/69253/1/MRS2018-33%20Topographical%20Changes%20of%20rat%27s%20Colonic%20Mucosal%20After%20Chronic%20Arsenic%20Exposure%20-A%20scanning%20electron%20microscopy%20study.pdf

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spelling	iium-692532019-01-18T01:11:59Z http://irep.iium.edu.my/69253/ Topographical changes of rat's colonic mucosal after chronic arsenic exposure - A scanning electron microscopy study Zulkiflee, Khodijah Buyong, Zunariah Hamdan, Asmah Hanim Saharudin, Shahida Wan Salleh, Wan Muhamad Salahudin R Medicine (General) Introduction: Human are exposed to arsenic threats in several ways. Our drinking water for instance, can be hazardous due to the contamination of arsenic-based pesticide and herbicide into our water supply. The most vulnerable part of our body due to ingestion of arsenic is our gastrointestinal system. Thus, the aim of this study was to determine the effects of chronic exposure to organic arsenic (Monosodium methylarsonate, MSMA) on the surface topography of rat's colonic mucosa by using scanning electron microscope (SEM). Materials and Methods: 30 Sprague Dawley rats were given daily oral gavage of MSMA 42.13 mg/kg, which is 1/30 LD50, and 30 Sprague Dawley rats acted as control. 10 exposed rats and 10 control rats were sacrificed at regular intervals (2 months, 4 months and 6 months) and their colon specimens were examined by SEM. Results: In the control group, the colonic mucosa appeared normal with uniform size individual glandular units and has a central crypt orifice. The goblet cells were located in between the absorptive cells to produce mucous. In the exposed group, the rat's colonic mucosa showed increasing features of surface alterations such as haphazard shape of glandular units, slit-like crypt opening and less goblet cells with reduced number of microvilli. Conclusion: There were topographical changes of colonic mucosa of rats exposed to chronic low dose of organic arsenic. Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia 2018-12-14 Article PeerReviewed application/pdf en http://irep.iium.edu.my/69253/1/MRS2018-33%20Topographical%20Changes%20of%20rat%27s%20Colonic%20Mucosal%20After%20Chronic%20Arsenic%20Exposure%20-A%20scanning%20electron%20microscopy%20study.pdf Zulkiflee, Khodijah and Buyong, Zunariah and Hamdan, Asmah Hanim and Saharudin, Shahida and Wan Salleh, Wan Muhamad Salahudin (2018) Topographical changes of rat's colonic mucosal after chronic arsenic exposure - A scanning electron microscopy study. International Medical Journal Malaysia, 17 (Supplementary Issue No 1). p. 32. E-ISSN 1823-4631 http://iiumedic.net/imjm/v1/download/vol_17_no_3_supp_1/MRS2018-33.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Zulkiflee, Khodijah Buyong, Zunariah Hamdan, Asmah Hanim Saharudin, Shahida Wan Salleh, Wan Muhamad Salahudin Topographical changes of rat's colonic mucosal after chronic arsenic exposure - A scanning electron microscopy study
description	Introduction: Human are exposed to arsenic threats in several ways. Our drinking water for instance, can be hazardous due to the contamination of arsenic-based pesticide and herbicide into our water supply. The most vulnerable part of our body due to ingestion of arsenic is our gastrointestinal system. Thus, the aim of this study was to determine the effects of chronic exposure to organic arsenic (Monosodium methylarsonate, MSMA) on the surface topography of rat's colonic mucosa by using scanning electron microscope (SEM). Materials and Methods: 30 Sprague Dawley rats were given daily oral gavage of MSMA 42.13 mg/kg, which is 1/30 LD50, and 30 Sprague Dawley rats acted as control. 10 exposed rats and 10 control rats were sacrificed at regular intervals (2 months, 4 months and 6 months) and their colon specimens were examined by SEM. Results: In the control group, the colonic mucosa appeared normal with uniform size individual glandular units and has a central crypt orifice. The goblet cells were located in between the absorptive cells to produce mucous. In the exposed group, the rat's colonic mucosa showed increasing features of surface alterations such as haphazard shape of glandular units, slit-like crypt opening and less goblet cells with reduced number of microvilli. Conclusion: There were topographical changes of colonic mucosa of rats exposed to chronic low dose of organic arsenic.
format	Article
author	Zulkiflee, Khodijah Buyong, Zunariah Hamdan, Asmah Hanim Saharudin, Shahida Wan Salleh, Wan Muhamad Salahudin
author_facet	Zulkiflee, Khodijah Buyong, Zunariah Hamdan, Asmah Hanim Saharudin, Shahida Wan Salleh, Wan Muhamad Salahudin
author_sort	Zulkiflee, Khodijah
title	Topographical changes of rat's colonic mucosal after chronic arsenic exposure - A scanning electron microscopy study
title_short	Topographical changes of rat's colonic mucosal after chronic arsenic exposure - A scanning electron microscopy study
title_full	Topographical changes of rat's colonic mucosal after chronic arsenic exposure - A scanning electron microscopy study
title_fullStr	Topographical changes of rat's colonic mucosal after chronic arsenic exposure - A scanning electron microscopy study
title_full_unstemmed	Topographical changes of rat's colonic mucosal after chronic arsenic exposure - A scanning electron microscopy study
title_sort	topographical changes of rat's colonic mucosal after chronic arsenic exposure - a scanning electron microscopy study
publisher	Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia
publishDate	2018
url	http://irep.iium.edu.my/69253/ http://irep.iium.edu.my/69253/ http://irep.iium.edu.my/69253/1/MRS2018-33%20Topographical%20Changes%20of%20rat%27s%20Colonic%20Mucosal%20After%20Chronic%20Arsenic%20Exposure%20-A%20scanning%20electron%20microscopy%20study.pdf
first_indexed	2023-09-18T21:38:18Z
last_indexed	2023-09-18T21:38:18Z
_version_	1777412969132457984

Topographical changes of rat's colonic mucosal after chronic arsenic exposure - A scanning electron microscopy study

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