Incorporation of stingless bee honey into hydrogel as a potential wound healing treatment

Honey is a well establish treatment for wound healing due to its antimicrobial, antioxidants, anti-inflammatory and high sugar contents. In this project, the stingless bee-based hydrogel formulation was developed and characterized. Response surface model (RSM) which is consist of factorial design an...

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Bibliographic Details
Main Authors:	Kasmuri, Abdul Razak, Ab. Hadi, Hazrina
Format:	Monograph
Language:	English
Published:	2019
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/69929/ http://irep.iium.edu.my/69929/1/IREP%20Report_FRGS.pdf

id	iium-69929
recordtype	eprints
spelling	iium-699292019-01-24T08:32:10Z http://irep.iium.edu.my/69929/ Incorporation of stingless bee honey into hydrogel as a potential wound healing treatment Kasmuri, Abdul Razak Ab. Hadi, Hazrina RS Pharmacy and materia medica Honey is a well establish treatment for wound healing due to its antimicrobial, antioxidants, anti-inflammatory and high sugar contents. In this project, the stingless bee-based hydrogel formulation was developed and characterized. Response surface model (RSM) which is consist of factorial design and central composite design was used to develop and optimized the hydrogel. The antimicrobial effects of the stingless bee honey can be observed in 30% v/v, 40% v/v, 50% and 100% v/v concentrations where there were zones of inhibition formed in the respective bacteria colonies. From the antimicrobial evaluation, stingless bee honey has the ability to inhibit the growth of pathogenic P. aeruginosa and S. aureus from 30% v/v concentration until fully 100% pure concentration. When incorporated into the hydrogel, the formulation developed also has this antimicrobial activity without compromising the value of the honey. The developed hydrogels themselves free from pathological microorganism that could further infected the skin based on the result from microbial limit test. For raw macrophages culture test, stingless bee honey did not show any significance changes toward the production of pro-inflammatory cytokines. The possible explanation is due to the immunomodulator properties of the honey where it has the ability to balance the production of pro-inflammatory cytokines when the level of cytokines is reduced or upsurge. In conclusion, the stingless bee honey as a natural wound healing promoter was successfully developed into an advanced pharmaceutical dosage form, hydrogel. 2019 Monograph NonPeerReviewed application/pdf en http://irep.iium.edu.my/69929/1/IREP%20Report_FRGS.pdf Kasmuri, Abdul Razak and Ab. Hadi, Hazrina (2019) Incorporation of stingless bee honey into hydrogel as a potential wound healing treatment. Research Report. UNSPECIFIED. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Kasmuri, Abdul Razak Ab. Hadi, Hazrina Incorporation of stingless bee honey into hydrogel as a potential wound healing treatment
description	Honey is a well establish treatment for wound healing due to its antimicrobial, antioxidants, anti-inflammatory and high sugar contents. In this project, the stingless bee-based hydrogel formulation was developed and characterized. Response surface model (RSM) which is consist of factorial design and central composite design was used to develop and optimized the hydrogel. The antimicrobial effects of the stingless bee honey can be observed in 30% v/v, 40% v/v, 50% and 100% v/v concentrations where there were zones of inhibition formed in the respective bacteria colonies. From the antimicrobial evaluation, stingless bee honey has the ability to inhibit the growth of pathogenic P. aeruginosa and S. aureus from 30% v/v concentration until fully 100% pure concentration. When incorporated into the hydrogel, the formulation developed also has this antimicrobial activity without compromising the value of the honey. The developed hydrogels themselves free from pathological microorganism that could further infected the skin based on the result from microbial limit test. For raw macrophages culture test, stingless bee honey did not show any significance changes toward the production of pro-inflammatory cytokines. The possible explanation is due to the immunomodulator properties of the honey where it has the ability to balance the production of pro-inflammatory cytokines when the level of cytokines is reduced or upsurge. In conclusion, the stingless bee honey as a natural wound healing promoter was successfully developed into an advanced pharmaceutical dosage form, hydrogel.
format	Monograph
author	Kasmuri, Abdul Razak Ab. Hadi, Hazrina
author_facet	Kasmuri, Abdul Razak Ab. Hadi, Hazrina
author_sort	Kasmuri, Abdul Razak
title	Incorporation of stingless bee honey into hydrogel as a potential wound healing treatment
title_short	Incorporation of stingless bee honey into hydrogel as a potential wound healing treatment
title_full	Incorporation of stingless bee honey into hydrogel as a potential wound healing treatment
title_fullStr	Incorporation of stingless bee honey into hydrogel as a potential wound healing treatment
title_full_unstemmed	Incorporation of stingless bee honey into hydrogel as a potential wound healing treatment
title_sort	incorporation of stingless bee honey into hydrogel as a potential wound healing treatment
publishDate	2019
url	http://irep.iium.edu.my/69929/ http://irep.iium.edu.my/69929/1/IREP%20Report_FRGS.pdf
first_indexed	2023-09-18T21:39:15Z
last_indexed	2023-09-18T21:39:15Z
_version_	1777413029244174336

Incorporation of stingless bee honey into hydrogel as a potential wound healing treatment

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