Theoretical modelling of interdigitated electrode sensor for mammalian cell characterization
Interdigitated Electrodes (IDEs) have been widely used in biological cellular characterization such as the Electrical Cell-Substrate Impedance Sensing (ECIS). Optimization of IDEs are crucial to obtain high accuracy of measurement that associates with the biological cell activities. However, no...
| Main Authors: | , |
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| Format: | Conference or Workshop Item |
| Language: | English English |
| Published: |
Institute of Electrical and Electronics Engineers Inc.
2018
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/70628/ http://irep.iium.edu.my/70628/ http://irep.iium.edu.my/70628/ http://irep.iium.edu.my/70628/9/70628_Theoretical%20modelling%20of%20interdigitated%20electrode.pdf http://irep.iium.edu.my/70628/2/70628_Theoretical%20modelling%20of%20interdigitated_SCOPUS.pdf |
| Summary: | Interdigitated Electrodes (IDEs) have been
widely used in biological cellular characterization such as the
Electrical Cell-Substrate Impedance Sensing (ECIS).
Optimization of IDEs are crucial to obtain high accuracy of
measurement that associates with the biological cell activities.
However, not much research studies the generation of electric
field by the IDEs geometry especially in cellular application. In
this work, theoretical modelling of IDEs was done by modelling
the IDEs equivalent circuit consisting of 3 major components;
double layer capacitance, CDL, solution capacitance, CSOL and
solution resistance, RSOL. Simulation using MATLAB and
COMSOL Multiphysics was done to study the effect of
geometrical parameters (width of electrodes (W), spacing
between electrodes (S) and total number of electrodes (N)) on
the cut-off frequency (FLOW), solution resistance (RSOL) and the
average electric field magnitude based on the equivalent circuit
model. The simulation results show three main findings; lowest
FLOW to be at the ratio of a=0.54 and N16, lowest RSOL at
smaller a and higher N, and saturated electric field at N18.
The results suggested that the optimal configuration of IDEs
with a fixed length of electrode of 7000μm is to have the ratio
of (S/W) as 0.54 and N as 18. |
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