Dominant-negative effect of a missense variant in the TASK-2 (KCNK5) K+ channel associated with Balkan endemic nephropathy
TASK-2, a member of the Two-Pore Domain (K2P) subfamily of K+ channels, is encoded by the KCNK5 gene. The channel is expressed primarily in renal epithelial tissues and a poten- tially deleterious missense variant in KCNK5 has recently been shown to be prevalent amongst patients predisposed to the d...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
PLOS
2016
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/71035/ http://irep.iium.edu.my/71035/ http://irep.iium.edu.my/71035/ http://irep.iium.edu.my/71035/1/journal.pone.0156456.PDF |