Does inappropriate prescription affect elderly patients’ quality of life? A study from a Malaysian tertiary hospital

To investigate the association between potentially inappropriate medication (PIM)/potential prescribing omission (PPO) and the health-related quality of life (HRQoL) among community-dwelling hospitalized elderly patients. Methods This is a cross-sectional study that took place in a Malaysian tertiar...

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Main Authors:	Akkawi, Muhammad Eid, Nik Mohamed, Mohamad Haniki, Md Aris, Mohd Aznan
Format:	Article
Language:	English
Published:	Springer International Publishing 2019
Subjects:	R Medicine (General) RS Pharmacy and materia medica RZ Other systems of medicine RZ400 Mental healing
Online Access:	http://irep.iium.edu.my/71046/ http://irep.iium.edu.my/71046/ http://irep.iium.edu.my/71046/ http://irep.iium.edu.my/71046/1/AP.%20Drm%20Mohd%20Aznan%20March%20Does%20inappropriate%20prescribing%20affect%20elderly%20patients%27%20quality%20of%20life%20A%20study%20from%20a%20Malaysian%20Tertiary%20hospital.pdf

id	iium-71046
recordtype	eprints
spelling	iium-710462019-03-12T06:46:45Z http://irep.iium.edu.my/71046/ Does inappropriate prescription affect elderly patients’ quality of life? A study from a Malaysian tertiary hospital Akkawi, Muhammad Eid Nik Mohamed, Mohamad Haniki Md Aris, Mohd Aznan R Medicine (General) RS Pharmacy and materia medica RZ Other systems of medicine RZ400 Mental healing To investigate the association between potentially inappropriate medication (PIM)/potential prescribing omission (PPO) and the health-related quality of life (HRQoL) among community-dwelling hospitalized elderly patients. Methods This is a cross-sectional study that took place in a Malaysian tertiary hospital. Patients ≥ 65 years old with at least one medication on admission were recruited. The patients’ prehospitalization medications were reviewed to identify PIMs/ PPOs using version 2 of the STOPP/START criteria. HRQoL was assessed using the EuroQol-5 dimensions (EQ-5D) and EuroQol-visual analog scale (EQ-VAS). The association between the presence of PIM/PPO and the patients’ HRQoL was analyzed using Chi-square and Mann–Whitney U tests. Multiple linear regression models were applied to determine the effect of exposure to PIM/PPO on the patients’ HRQoL, adjusting for confounders. Results Out of 517 patients who fulfilled the inclusion criteria, 502 patients (97%) accepted to be involved in the study and completed the HRQoL questionnaire. The mean (SD) age was 72.4 (5.9) years. 393 (78.3%) of the patients had problems in at least one EQ-5D dimension with pain/discomfort problem being the most reported complaint. The mean (SD) values of the EQ-5D index and the EQ-VAS were 0.734 (0.214) and 59.6 (14.2), respectively, which are lower than those seen in the general Malaysian population. PIM and PPO were found in 28.5% and 45.6% of the patients, respectively. No significant differences were found in the EQ-5D dimensions, EQ-5D index and EQ-VAS between patients who had PIM/PPO and those who did not. Age, sex, and comorbidities were significantly associated with the patients’ HRQoL. Conclusion PIM and PPO are not uncommon among hospitalized elderly patients; however, it does not significantly affect their HRQoL as measured by the EQ-5D-3L instrument. Springer International Publishing 2019-03-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/71046/1/AP.%20Drm%20Mohd%20Aznan%20March%20Does%20inappropriate%20prescribing%20affect%20elderly%20patients%27%20quality%20of%20life%20A%20study%20from%20a%20Malaysian%20Tertiary%20hospital.pdf Akkawi, Muhammad Eid and Nik Mohamed, Mohamad Haniki and Md Aris, Mohd Aznan (2019) Does inappropriate prescription affect elderly patients’ quality of life? A study from a Malaysian tertiary hospital. Quality of Life Research. pp. 1-8. ISSN 0962-9343 E-ISSN 1573-2649 (In Press) https://link.springer.com/article/10.1007/s11136-019-02153-5#citeas 10.1007/s11136-019-02153-5
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General) RS Pharmacy and materia medica RZ Other systems of medicine RZ400 Mental healing
spellingShingle	R Medicine (General) RS Pharmacy and materia medica RZ Other systems of medicine RZ400 Mental healing Akkawi, Muhammad Eid Nik Mohamed, Mohamad Haniki Md Aris, Mohd Aznan Does inappropriate prescription affect elderly patients’ quality of life? A study from a Malaysian tertiary hospital
description	To investigate the association between potentially inappropriate medication (PIM)/potential prescribing omission (PPO) and the health-related quality of life (HRQoL) among community-dwelling hospitalized elderly patients. Methods This is a cross-sectional study that took place in a Malaysian tertiary hospital. Patients ≥ 65 years old with at least one medication on admission were recruited. The patients’ prehospitalization medications were reviewed to identify PIMs/ PPOs using version 2 of the STOPP/START criteria. HRQoL was assessed using the EuroQol-5 dimensions (EQ-5D) and EuroQol-visual analog scale (EQ-VAS). The association between the presence of PIM/PPO and the patients’ HRQoL was analyzed using Chi-square and Mann–Whitney U tests. Multiple linear regression models were applied to determine the effect of exposure to PIM/PPO on the patients’ HRQoL, adjusting for confounders. Results Out of 517 patients who fulfilled the inclusion criteria, 502 patients (97%) accepted to be involved in the study and completed the HRQoL questionnaire. The mean (SD) age was 72.4 (5.9) years. 393 (78.3%) of the patients had problems in at least one EQ-5D dimension with pain/discomfort problem being the most reported complaint. The mean (SD) values of the EQ-5D index and the EQ-VAS were 0.734 (0.214) and 59.6 (14.2), respectively, which are lower than those seen in the general Malaysian population. PIM and PPO were found in 28.5% and 45.6% of the patients, respectively. No significant differences were found in the EQ-5D dimensions, EQ-5D index and EQ-VAS between patients who had PIM/PPO and those who did not. Age, sex, and comorbidities were significantly associated with the patients’ HRQoL. Conclusion PIM and PPO are not uncommon among hospitalized elderly patients; however, it does not significantly affect their HRQoL as measured by the EQ-5D-3L instrument.
format	Article
author	Akkawi, Muhammad Eid Nik Mohamed, Mohamad Haniki Md Aris, Mohd Aznan
author_facet	Akkawi, Muhammad Eid Nik Mohamed, Mohamad Haniki Md Aris, Mohd Aznan
author_sort	Akkawi, Muhammad Eid
title	Does inappropriate prescription affect elderly patients’ quality of life? A study from a Malaysian tertiary hospital
title_short	Does inappropriate prescription affect elderly patients’ quality of life? A study from a Malaysian tertiary hospital
title_full	Does inappropriate prescription affect elderly patients’ quality of life? A study from a Malaysian tertiary hospital
title_fullStr	Does inappropriate prescription affect elderly patients’ quality of life? A study from a Malaysian tertiary hospital
title_full_unstemmed	Does inappropriate prescription affect elderly patients’ quality of life? A study from a Malaysian tertiary hospital
title_sort	does inappropriate prescription affect elderly patients’ quality of life? a study from a malaysian tertiary hospital
publisher	Springer International Publishing
publishDate	2019
url	http://irep.iium.edu.my/71046/ http://irep.iium.edu.my/71046/ http://irep.iium.edu.my/71046/ http://irep.iium.edu.my/71046/1/AP.%20Drm%20Mohd%20Aznan%20March%20Does%20inappropriate%20prescribing%20affect%20elderly%20patients%27%20quality%20of%20life%20A%20study%20from%20a%20Malaysian%20Tertiary%20hospital.pdf
first_indexed	2023-09-18T21:40:50Z
last_indexed	2023-09-18T21:40:50Z
_version_	1777413128975286272

Does inappropriate prescription affect elderly patients’ quality of life? A study from a Malaysian tertiary hospital

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