Class III malocclusion: missense mutations in DUSP6 gene

Objective: To determine the DUSP6 gene mutation in three generations of Malaysian Malay subjects having Class III malocclusion. Material and Methods: Genetic analyses of DUSP6 gene were carried out in 30 subjects by selecting three individuals representing three generations, respectively, from ten M...

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Main Authors:	Nowrin, Shifat A., Basri, Rehana, Alam, Mohammad Khursheed, Jaafar, Saidi, Mokhtar@Makhtar, Khairani Idah
Format:	Article
Language:	English English
Published:	Association Support to Oral Health Research 2019
Subjects:	RK Dentistry
Online Access:	http://irep.iium.edu.my/71468/ http://irep.iium.edu.my/71468/ http://irep.iium.edu.my/71468/ http://irep.iium.edu.my/71468/1/71468_Class%20III%20Malocclusion.pdf http://irep.iium.edu.my/71468/7/71468_Class%20III%20malocclusion_scopus.pdf

id	iium-71468
recordtype	eprints
spelling	iium-714682019-11-24T10:55:51Z http://irep.iium.edu.my/71468/ Class III malocclusion: missense mutations in DUSP6 gene Nowrin, Shifat A. Basri, Rehana Alam, Mohammad Khursheed Jaafar, Saidi Mokhtar@Makhtar, Khairani Idah RK Dentistry Objective: To determine the DUSP6 gene mutation in three generations of Malaysian Malay subjects having Class III malocclusion. Material and Methods: Genetic analyses of DUSP6 gene were carried out in 30 subjects by selecting three individuals representing three generations, respectively, from ten Malaysian Malay families having Class III malocclusion and 30 healthy controls. They were submitted Clinical Evaluation to clinical examination, lateral cephalometric radiographs, dental casts, and/ or facial and intra-oral photographs. Buccal cell was taken from each participant of Class III malocclusion and control groups. DNA extractions from buccal cell were carried out using Gentra puregene buccal cell kit. Bio Edit Sequence Alignment Editor software was used to see the sequencing result. Results: A heterozygous missense mutation c.1094C>T (p. Thr 365 Ile) was identified in DUSP6 gene in three members of one family with Class III malocclusion, whereas no mutation was found in the control group. Conclusion: Current study successfully identified a missense mutation in DUSP6 gene among one Malaysian Malay family affected by Class III malocclusion. The outcome of this study broadened the mutation spectrum of Class III malocclusion and the importance of DUSP6 gene in skeletal functions. Association Support to Oral Health Research 2019-03-25 Article PeerReviewed application/pdf en http://irep.iium.edu.my/71468/1/71468_Class%20III%20Malocclusion.pdf application/pdf en http://irep.iium.edu.my/71468/7/71468_Class%20III%20malocclusion_scopus.pdf Nowrin, Shifat A. and Basri, Rehana and Alam, Mohammad Khursheed and Jaafar, Saidi and Mokhtar@Makhtar, Khairani Idah (2019) Class III malocclusion: missense mutations in DUSP6 gene. Pesquisa Brasileira em Odontopediatria e Clínica Integrada / Brazilian Research in Pediatric Dentistry and Integrated Clinic (PBOCI), 19 (1). pp. 1-8. ISSN 1519-0501 E-ISSN 1983-4632 http://revista.uepb.edu.br/index.php/pboci/article/view/4709/pdf http://doi.org/10.4034/PBOCI.2019.191.65
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RK Dentistry
spellingShingle	RK Dentistry Nowrin, Shifat A. Basri, Rehana Alam, Mohammad Khursheed Jaafar, Saidi Mokhtar@Makhtar, Khairani Idah Class III malocclusion: missense mutations in DUSP6 gene
description	Objective: To determine the DUSP6 gene mutation in three generations of Malaysian Malay subjects having Class III malocclusion. Material and Methods: Genetic analyses of DUSP6 gene were carried out in 30 subjects by selecting three individuals representing three generations, respectively, from ten Malaysian Malay families having Class III malocclusion and 30 healthy controls. They were submitted Clinical Evaluation to clinical examination, lateral cephalometric radiographs, dental casts, and/ or facial and intra-oral photographs. Buccal cell was taken from each participant of Class III malocclusion and control groups. DNA extractions from buccal cell were carried out using Gentra puregene buccal cell kit. Bio Edit Sequence Alignment Editor software was used to see the sequencing result. Results: A heterozygous missense mutation c.1094C>T (p. Thr 365 Ile) was identified in DUSP6 gene in three members of one family with Class III malocclusion, whereas no mutation was found in the control group. Conclusion: Current study successfully identified a missense mutation in DUSP6 gene among one Malaysian Malay family affected by Class III malocclusion. The outcome of this study broadened the mutation spectrum of Class III malocclusion and the importance of DUSP6 gene in skeletal functions.
format	Article
author	Nowrin, Shifat A. Basri, Rehana Alam, Mohammad Khursheed Jaafar, Saidi Mokhtar@Makhtar, Khairani Idah
author_facet	Nowrin, Shifat A. Basri, Rehana Alam, Mohammad Khursheed Jaafar, Saidi Mokhtar@Makhtar, Khairani Idah
author_sort	Nowrin, Shifat A.
title	Class III malocclusion: missense mutations in DUSP6 gene
title_short	Class III malocclusion: missense mutations in DUSP6 gene
title_full	Class III malocclusion: missense mutations in DUSP6 gene
title_fullStr	Class III malocclusion: missense mutations in DUSP6 gene
title_full_unstemmed	Class III malocclusion: missense mutations in DUSP6 gene
title_sort	class iii malocclusion: missense mutations in dusp6 gene
publisher	Association Support to Oral Health Research
publishDate	2019
url	http://irep.iium.edu.my/71468/ http://irep.iium.edu.my/71468/ http://irep.iium.edu.my/71468/ http://irep.iium.edu.my/71468/1/71468_Class%20III%20Malocclusion.pdf http://irep.iium.edu.my/71468/7/71468_Class%20III%20malocclusion_scopus.pdf
first_indexed	2023-09-18T21:41:20Z
last_indexed	2023-09-18T21:41:20Z
_version_	1777413160510160896

Class III malocclusion: missense mutations in DUSP6 gene

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