Exploration of change in persistence patterns of opioid use among patients with non-cancer and cancer pain over a three-year follow-up period

Background: Little is known about the different patterns of persistent opioid use and whether the patterns of clinical opioid use remain the same throughout the long-term opioid therapy. Aim: This study explores the different patterns of persistent opioid use and the change in these patterns over...

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Main Authors:	Abdullah Sani, Asween Rowena, Zin, Che Suraya, Mohamed, Abdul Hadi, Izat, Munira, Tan, Hung Ling, Ng, Kim Swan, Nissen, Lisa M.
Format:	Article
Language:	English English
Published:	The Society of Hospital Pharmacists of Australia 2019
Subjects:	RM Therapeutics. Pharmacology RM147 Administration of Drugs and Other Therapeutic Agents
Online Access:	http://irep.iium.edu.my/71530/ http://irep.iium.edu.my/71530/ http://irep.iium.edu.my/71530/1/190408_Main%20manuscript_persistence_opioid_JPPR_full_article.pdf http://irep.iium.edu.my/71530/2/190408_Acceptance_JPPR.JPG

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spelling	iium-715302019-04-10T03:14:12Z http://irep.iium.edu.my/71530/ Exploration of change in persistence patterns of opioid use among patients with non-cancer and cancer pain over a three-year follow-up period Abdullah Sani, Asween Rowena Zin, Che Suraya Mohamed, Abdul Hadi Izat, Munira Tan, Hung Ling Ng, Kim Swan Nissen, Lisa M. Ng, Kim Swan RM Therapeutics. Pharmacology RM147 Administration of Drugs and Other Therapeutic Agents Background: Little is known about the different patterns of persistent opioid use and whether the patterns of clinical opioid use remain the same throughout the long-term opioid therapy. Aim: This study explores the different patterns of persistent opioid use and the change in these patterns over time in patients with non-cancer and cancer pain. Method: This retrospective cross-sectional study included patients with non-cancer and cancer pain receiving opioid prescriptions during 2013-2015 at outpatient tertiary hospital settings in Malaysia. A three-dimensional persistence measure consisting of treatment intensity, frequency and distribution were used to define persistent opioid users as wide (use opioids most of the days in a year), intermediate (use opioids daily) or strict (use opioids continuously to achieve a therapeutic concentration) users. The number of patients in each persistence definition and the change in persistence patterns over time was recorded. Results: Majority of persistent opioid users in the non-cancer and cancer groups were in the wide (9.3% vs.4.8%), followed by intermediate (3.1% vs.0.5%), and strict (1.8% vs.0.9%) definitions. Over a three-year study duration, change to a less stringent persistence definition was observed in the non-cancer group whereas no discernible pattern of change was observed in the cancer group. Conclusion: Change in the patterns of clinical opioid use over time was detected among persistent opioid users in both non-cancer and cancer groups using a three-dimensional persistence measure. This measure which is sensitive to the changes in clinical use of opioids over time can greatly impact future research and practices for better pain management involving opioids. The Society of Hospital Pharmacists of Australia 2019-04-07 Article PeerReviewed application/pdf en http://irep.iium.edu.my/71530/1/190408_Main%20manuscript_persistence_opioid_JPPR_full_article.pdf application/pdf en http://irep.iium.edu.my/71530/2/190408_Acceptance_JPPR.JPG Abdullah Sani, Asween Rowena and Zin, Che Suraya and Mohamed, Abdul Hadi and Izat, Munira and Tan, Hung Ling and Ng, Kim Swan and Nissen, Lisa M. and Ng, Kim Swan (2019) Exploration of change in persistence patterns of opioid use among patients with non-cancer and cancer pain over a three-year follow-up period. Journal of Pharmacy Practice and Research, xx (xx). pp. 1-25. ISSN 2055-2335 (In Press) https://onlinelibrary.wiley.com/journal/20552335
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RM Therapeutics. Pharmacology RM147 Administration of Drugs and Other Therapeutic Agents
spellingShingle	RM Therapeutics. Pharmacology RM147 Administration of Drugs and Other Therapeutic Agents Abdullah Sani, Asween Rowena Zin, Che Suraya Mohamed, Abdul Hadi Izat, Munira Tan, Hung Ling Ng, Kim Swan Nissen, Lisa M. Ng, Kim Swan Exploration of change in persistence patterns of opioid use among patients with non-cancer and cancer pain over a three-year follow-up period
description	Background: Little is known about the different patterns of persistent opioid use and whether the patterns of clinical opioid use remain the same throughout the long-term opioid therapy. Aim: This study explores the different patterns of persistent opioid use and the change in these patterns over time in patients with non-cancer and cancer pain. Method: This retrospective cross-sectional study included patients with non-cancer and cancer pain receiving opioid prescriptions during 2013-2015 at outpatient tertiary hospital settings in Malaysia. A three-dimensional persistence measure consisting of treatment intensity, frequency and distribution were used to define persistent opioid users as wide (use opioids most of the days in a year), intermediate (use opioids daily) or strict (use opioids continuously to achieve a therapeutic concentration) users. The number of patients in each persistence definition and the change in persistence patterns over time was recorded. Results: Majority of persistent opioid users in the non-cancer and cancer groups were in the wide (9.3% vs.4.8%), followed by intermediate (3.1% vs.0.5%), and strict (1.8% vs.0.9%) definitions. Over a three-year study duration, change to a less stringent persistence definition was observed in the non-cancer group whereas no discernible pattern of change was observed in the cancer group. Conclusion: Change in the patterns of clinical opioid use over time was detected among persistent opioid users in both non-cancer and cancer groups using a three-dimensional persistence measure. This measure which is sensitive to the changes in clinical use of opioids over time can greatly impact future research and practices for better pain management involving opioids.
format	Article
author	Abdullah Sani, Asween Rowena Zin, Che Suraya Mohamed, Abdul Hadi Izat, Munira Tan, Hung Ling Ng, Kim Swan Nissen, Lisa M. Ng, Kim Swan
author_facet	Abdullah Sani, Asween Rowena Zin, Che Suraya Mohamed, Abdul Hadi Izat, Munira Tan, Hung Ling Ng, Kim Swan Nissen, Lisa M. Ng, Kim Swan
author_sort	Abdullah Sani, Asween Rowena
title	Exploration of change in persistence patterns of opioid use among patients with non-cancer and cancer pain over a three-year follow-up period
title_short	Exploration of change in persistence patterns of opioid use among patients with non-cancer and cancer pain over a three-year follow-up period
title_full	Exploration of change in persistence patterns of opioid use among patients with non-cancer and cancer pain over a three-year follow-up period
title_fullStr	Exploration of change in persistence patterns of opioid use among patients with non-cancer and cancer pain over a three-year follow-up period
title_full_unstemmed	Exploration of change in persistence patterns of opioid use among patients with non-cancer and cancer pain over a three-year follow-up period
title_sort	exploration of change in persistence patterns of opioid use among patients with non-cancer and cancer pain over a three-year follow-up period
publisher	The Society of Hospital Pharmacists of Australia
publishDate	2019
url	http://irep.iium.edu.my/71530/ http://irep.iium.edu.my/71530/ http://irep.iium.edu.my/71530/1/190408_Main%20manuscript_persistence_opioid_JPPR_full_article.pdf http://irep.iium.edu.my/71530/2/190408_Acceptance_JPPR.JPG
first_indexed	2023-09-18T21:41:25Z
last_indexed	2023-09-18T21:41:25Z
_version_	1777413165857898496

Exploration of change in persistence patterns of opioid use among patients with non-cancer and cancer pain over a three-year follow-up period

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