Evaluation of the α-glucosidase inhibitory and free radical scavenging activities of selected traditional medicine plant species used in treating diabetes

Plants constitute a major ingredient in traditional or folk medicine. The therapeutic claims made on the use of these traditional medicinal plants range from simple conditions such as fevers and migraines, to more complex diseases such as cancer, metabolic syndrome and diabetes mellitus. The aque...

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Main Authors:	W. A., Wan Nadilah, Shaari, Khozirah, Khatib, Alfi, Hamid, A.A., Hamid, M.
Format:	Article
Language:	English English English
Published:	Universiti Putra Malaysia (UPM) 2019
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/71835/ http://irep.iium.edu.my/71835/ http://irep.iium.edu.my/71835/1/71835_Evaluation%20of%20the%20alpha-glucosidase%20inhibitory_article.pdf http://irep.iium.edu.my/71835/2/71835_Evaluation%20of%20the%20alpha-glucosidase%20inhibitory_wos.pdf http://irep.iium.edu.my/71835/13/71835_Evaluation%20of%20the%20%CE%B1-glucosidase%20inhibitory_scopus.pdf

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recordtype	eprints
spelling	iium-718352020-03-06T05:43:47Z http://irep.iium.edu.my/71835/ Evaluation of the α-glucosidase inhibitory and free radical scavenging activities of selected traditional medicine plant species used in treating diabetes W. A., Wan Nadilah Shaari, Khozirah Khatib, Alfi Hamid, A.A. Hamid, M. RS Pharmacy and materia medica Plants constitute a major ingredient in traditional or folk medicine. The therapeutic claims made on the use of these traditional medicinal plants range from simple conditions such as fevers and migraines, to more complex diseases such as cancer, metabolic syndrome and diabetes mellitus. The aqueous ethanolic extracts of five medicinal plant species; Cosmos caudatus, Leucaena leucocephala, Momordica charantia, Pereskia bleo and Averrhoa bilimbi were assessed for glucose lowering effect via the in vitro α-glucosidase inhibition assay. Their antioxidant potential, represented by their DPPH radical scavenging activity and total phenolic contents were also measured. The most potent α-glucosidase inhibitory activity was recorded for the leaf extract of C. caudatus with IC50 of 21.90 ± 3.60 µg/mL, followed by L. leucocephala with IC50 value of 30.80 ± 2.50 µg/mL. Momordica charantia, P. bleo and A. bilimbi did not show any significant inhibition of α-glucosidase. Meanwhile C. caudatus also gave the highest DPPH radical scavenging activity with IC50 value of 272.46 ± 8.98 µg/mL, and the highest total phenolic content with a value of 0.263 ± 0.02 g GAE/g DW. The present work provides a priority list of interesting plants for further study with respect to the treatment of diabetes. Universiti Putra Malaysia (UPM) 2019 Article PeerReviewed application/pdf en http://irep.iium.edu.my/71835/1/71835_Evaluation%20of%20the%20alpha-glucosidase%20inhibitory_article.pdf application/pdf en http://irep.iium.edu.my/71835/2/71835_Evaluation%20of%20the%20alpha-glucosidase%20inhibitory_wos.pdf application/pdf en http://irep.iium.edu.my/71835/13/71835_Evaluation%20of%20the%20%CE%B1-glucosidase%20inhibitory_scopus.pdf W. A., Wan Nadilah and Shaari, Khozirah and Khatib, Alfi and Hamid, A.A. and Hamid, M. (2019) Evaluation of the α-glucosidase inhibitory and free radical scavenging activities of selected traditional medicine plant species used in treating diabetes. International Food Research Journal, 26 (1). pp. 75-85. ISSN 1985-4668 E-ISSN 2231-7546 http://www.ifrj.upm.edu.my/26%20(01)%202019/(8).pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica W. A., Wan Nadilah Shaari, Khozirah Khatib, Alfi Hamid, A.A. Hamid, M. Evaluation of the α-glucosidase inhibitory and free radical scavenging activities of selected traditional medicine plant species used in treating diabetes
description	Plants constitute a major ingredient in traditional or folk medicine. The therapeutic claims made on the use of these traditional medicinal plants range from simple conditions such as fevers and migraines, to more complex diseases such as cancer, metabolic syndrome and diabetes mellitus. The aqueous ethanolic extracts of five medicinal plant species; Cosmos caudatus, Leucaena leucocephala, Momordica charantia, Pereskia bleo and Averrhoa bilimbi were assessed for glucose lowering effect via the in vitro α-glucosidase inhibition assay. Their antioxidant potential, represented by their DPPH radical scavenging activity and total phenolic contents were also measured. The most potent α-glucosidase inhibitory activity was recorded for the leaf extract of C. caudatus with IC50 of 21.90 ± 3.60 µg/mL, followed by L. leucocephala with IC50 value of 30.80 ± 2.50 µg/mL. Momordica charantia, P. bleo and A. bilimbi did not show any significant inhibition of α-glucosidase. Meanwhile C. caudatus also gave the highest DPPH radical scavenging activity with IC50 value of 272.46 ± 8.98 µg/mL, and the highest total phenolic content with a value of 0.263 ± 0.02 g GAE/g DW. The present work provides a priority list of interesting plants for further study with respect to the treatment of diabetes.
format	Article
author	W. A., Wan Nadilah Shaari, Khozirah Khatib, Alfi Hamid, A.A. Hamid, M.
author_facet	W. A., Wan Nadilah Shaari, Khozirah Khatib, Alfi Hamid, A.A. Hamid, M.
author_sort	W. A., Wan Nadilah
title	Evaluation of the α-glucosidase inhibitory and free radical scavenging activities of selected traditional medicine plant species used in treating diabetes
title_short	Evaluation of the α-glucosidase inhibitory and free radical scavenging activities of selected traditional medicine plant species used in treating diabetes
title_full	Evaluation of the α-glucosidase inhibitory and free radical scavenging activities of selected traditional medicine plant species used in treating diabetes
title_fullStr	Evaluation of the α-glucosidase inhibitory and free radical scavenging activities of selected traditional medicine plant species used in treating diabetes
title_full_unstemmed	Evaluation of the α-glucosidase inhibitory and free radical scavenging activities of selected traditional medicine plant species used in treating diabetes
title_sort	evaluation of the α-glucosidase inhibitory and free radical scavenging activities of selected traditional medicine plant species used in treating diabetes
publisher	Universiti Putra Malaysia (UPM)
publishDate	2019
url	http://irep.iium.edu.my/71835/ http://irep.iium.edu.my/71835/ http://irep.iium.edu.my/71835/1/71835_Evaluation%20of%20the%20alpha-glucosidase%20inhibitory_article.pdf http://irep.iium.edu.my/71835/2/71835_Evaluation%20of%20the%20alpha-glucosidase%20inhibitory_wos.pdf http://irep.iium.edu.my/71835/13/71835_Evaluation%20of%20the%20%CE%B1-glucosidase%20inhibitory_scopus.pdf
first_indexed	2023-09-18T21:41:51Z
last_indexed	2023-09-18T21:41:51Z
_version_	1777413192450834432

Evaluation of the α-glucosidase inhibitory and free radical scavenging activities of selected traditional medicine plant species used in treating diabetes

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